Study on synthesis and properties of 3′,5′-dioctanoyl-5-fluoro-2′-deoxyuridine

Chinese Pharmaceutical Journal

Volumn 36, Issue 11, 2001, Pages 767-770

  Wang, J X ^a   Zhang, Z R ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

3 ,5 Dioctanoyl 5 fluoro 2 deoxyuridine; 5 Fluoro 2 deoxyuridine; Cytotoxicity; Degradation kinetics; Synthesis

Indexed keywords

HYDROLYSIS; INFRARED SPECTROSCOPY; NUCLEAR MAGNETIC RESONANCE; SOLUBILITY; SYNTHESIS (CHEMICAL); TISSUE;

LIPOPHICITY;

DRUG PRODUCTS;

BUFFER; FLOXURIDINE 3',5' DIOCTANOATE; PRODRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL PROLIFERATION; CHEMICAL STRUCTURE; DEGRADATION KINETICS; DRUG CYTOTOXICITY; DRUG HYDROLYSIS; DRUG SOLUBILITY; DRUG SYNTHESIS; GLIOMA CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFRARED SPECTROPHOTOMETRY; LIPOPHILICITY; MASS SPECTROMETRY; PLASMA; PROTON NUCLEAR MAGNETIC RESONANCE; TISSUE HOMOGENATE;

EID: 0035677649     PISSN: 10012494     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. 3′,5′-Diesters of 5- fluoro-2′-deoxyuridine: Synthesis and biological activity [J]
2. Ester prodrugs of a potent nalgesic, morphine-6-sulfate: Syntheses, spectroscopic and physicochemical properties[J]
3. In vitro study on intrathecal application of 5-fluoro-2′-deoxyuridine(FdUrd) for meningeal dissemination of malignant tumor[J]
4. Selective accumulation of 3′, 5′-dioctanoyl-5-fluoro-2′-deoxyuridine (FdUrd-C8) and sustained release of its active metabolites in VX-2 rabbit hepatoma following intraarterial administration of FdUrd-C8 solution in lipiodol[J]
5. Selective antiancer effects of 3′, 5′-dioctanoyl-5-fluoro-2′-deoxyuridine, a lipophilic prodrug of 5-fluoro-2′-deoxyuridine, dissolved in an oily lymphographic agent on hepatic cancer of rabbits bearing VX-2 tumor[J]
6. Activity of esterase in the hydrolysis of 3′,5′-diesters of 5-fluoro-2′-deoxyuridine in relation to the strucure of the diester prodrugs[J]