Tyrosine kinase activation in breast carcinoma with correlation to HER-2/neu gene amplification and receptor overexpression

Human Pathology

Volumn 32, Issue 12, 2001, Pages 1344-1350

  Bhargava, Rohit ^a,b   Naeem, Rizwan ^a,b   Marconi, Sharon ^a,b   Luszcz, Jason ^a,b   Garb, Jane ^a,b   Gasparini, Robert ^a,b   Otis, Christopher N ^a,b  

^a BAYSTATE MEDICAL CENTER   (United States)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Breast carcinoma; HER 2 neu; Tyrosine kinase

Indexed keywords

ESTROGEN RECEPTOR; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CB11; ONCOPROTEIN; PHOSPHOTYROSINE; PROGESTERONE RECEPTOR; PROTEIN TYROSINE KINASE; TRASTUZUMAB; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; CANCER SIZE; CHROMOSOME 17Q; CHROMOSOME 7; ENZYME ACTIVITY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; ONCOGENE NEU; PROTO ONCOGENE;

EID: 0035677063     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1053/hupa.2001.29668     Document Type: Article

References (24)

1. The neu oncogene encodes an epidermal growth factor receptor-related protein
2. The neu gene: An erb B-homologous gene distinct from and unlinked to the gene encoding the EGF receptor
3. Amplification of a novel v-erbB-related gene in a human mammary carcinoma
4. Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene
5. Localization of the erbB-2 gene on normal and rearranged chromosomes 17 to bands q12-21.32
6. The neu oncogene: An erb-B-related gene encoding a 185, 000-Mr tumor antigen
7. Similarity of protein encoded by the human c-erb B-2 gene to epidermal growth factor receptor
8. HER-2/neu signal transduction in human breast and ovarian cancer
9. Signal transduction by receptors with tyrosine kinase activity
10. Protein tyrosine kinase receptors
11. Regulation of signal transduction and signal diversity by receptor oligomerization
12. The transforming potential of the c-erbB-2 protein is regulated by its autophosphorylation at the carboxy-terminal domain
13. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal regulated kinase activation
14. Pathological prognostic factors in breast cancer. I. The value of histological grades in breast cancer. Experience from a large study with long-term follow-up
15. Interobserver reproducibility of the Nottingham modification of the Bloom and Richardson histologic grading scheme for infiltrating ductal carcinoma
16. Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
17. Overexpression of the c-erbB-2 oncoprotein in human breast carcinomas: Immunohistochemical assessment correlates with gene amplification
18. Expression of the p185 encoded by HER-2 oncogene in normal and transformed human tissues
19. HER-2/neu analysis in archival tissue samples of human breast cancer: Comparison of immunohistochemistry and fluorescence in situ hybridization
20. Discrepancies in clinical laboratory testing of eligibility for trastuzumab therapy: Apparent immunohistochemical false-positives do not get the message
21. Type 1 protein tyrosine kinases in benign and malignant breast lesions
22. Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project. Significance of erbB-2 protein overexpression in primary, breast cancer
23. Prognostic significance of HER-2 oncoprotein expression in breast cancer: A 30-year follow up
24. Expression of c-erbB-2 oncoprotein: A prognostic indicator in human breast cancer