Plasma of patients with Upshaw-Schulman syndrome, a congenital deficiency of von Willebrand factor-cleaving protease activity, enhances the aggregation of normal platelets under high shear stress

British Journal of Haematology

Volumn 115, Issue 4, 2001, Pages 991-997

  Yagi, H ^a   Konno, M ^b   Kinoshita, S ^c   Matsumoto, M ^a   Ishizashi, H ^a   Matsui, T ^d   Titani, K ^d   Fujimura, Y ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

^b Sapporo Kosei General Hospital   (Japan)

^c OSAKA CITY GENERAL HOSPITAL   (Japan)

^d FUJITA HEALTH UNIVERSITY   (Japan)

Author keywords

Chronic relapsing thrombotic thrombocytopenic purpura; High shear stress induced platelet aggregation; Unusually large von Willebrand factor multimer; Upshaw Schulman syndrome; Von Willebrand factor cleaving protease

Indexed keywords

ADENOSINE DIPHOSPHATE; FRESH FROZEN PLASMA; GLYCOPROTEIN IB; PROTEINASE; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR CLEAVING PROTEINASE;

ARTICLE; BLOOD LEVEL; CASE REPORT; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVITY; FEMALE; HEMATOLOGIC DISEASE; HUMAN; INFUSION; MICROCIRCULATION; PRIORITY JOURNAL; SHEAR STRESS; SYMPTOM; THROMBOCYTE AGGREGATION; THROMBOCYTOPENIA; UPSHAW SCHULMAN SYNDROME;

ADAM PROTEINS; ADOLESCENT; ANEMIA, HEMOLYTIC; FEMALE; HUMANS; METALLOENDOPEPTIDASES; PLASMA; PLATELET AGGREGATION; PLATELET COUNT; STRESS, MECHANICAL; SYNDROME; THROMBOCYTOPENIA; VON WILLEBRAND FACTOR;

EID: 0035677047     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2001.03222.x     Document Type: Article

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