Aneusomy of chromosomes 7, 8, and 17 and amplification of HER-2/neu and epidermal growth factor receptor in Gleason score 7 prostate carcinoma: A differential fluorescent in situ hybridization study of Gleason pattern 3 and 4 using tissue microarray

Human Pathology

Volumn 32, Issue 12, 2001, Pages 1392-1397

  Skacel, Marek ^a   Ormsby, Adrian H ^a   Pettay, James D ^a   Tsiftsakis, Evangelos K ^a   Liou, Louis S ^a   Klein, Eric A ^a   Levin, Howard S ^a   Zippe, Craig D ^a   Tubbs, Raymond R ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Biochemical recurrence; Fluorescence in situ hybridization; Gleason pattern; Prostate cancer

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; ONCOPROTEIN;

ADULT; AGED; ANEUPLOIDY; ARTICLE; CANCER GROWTH; CANCER LOCALIZATION; CANCER STAGING; CHROMOSOME 17; CHROMOSOME 7; CHROMOSOME 8; CHROMOSOME ABERRATION; CLINICAL ARTICLE; CYTOKINE PRODUCTION; DNA MICROARRAY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; HUMAN; MALE; MOLECULAR GENETICS; ONCOGENE NEU; PROSTATE CARCINOMA; PROSTATECTOMY;

EID: 0035676477     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1053/hupa.2001.29676     Document Type: Article

References (31)

1. Temporal trends in rates of prostate cancer: Declining incidence of advanced stage disease, 1974-1994
2. Biological determinants of cancer progression in men with prostate cancer
3. Prognostic significance of Gleason score 3+4 versus 4+3 tumor at radical prostatectomy
4. The relative amount of Gleason pattern 4 tumor and surgical margin status are independent prognostic factors in Gleason score 7 prostate carcinoma after radical prostatectomy
5. The impact of positive surgical margin and Gleason pattern 4 tumor on the biochemical failure after radical prostatectomy
6. Gleason sum and percent Gleason grade 4/5 as predictors of the natural history of prostate cancer
7. Primary Gleason pattern as a predictor of disease progression in Gleason score 7 prostate cancer: A multivariate analysis of 823 men treated with radical prostatectomy
8. Tissue microarrays for high-throughput molecular profiling of tumor specimens
9. Validation of tissue microarrays for immunohistochemical profiling of cancer specimens using the example of human fibroblastic tumors
10. Tissue microarrays - A powerful tool in anatomic pathology: A review of the method with validation data
11. Evaluation of prognostic factors in intermediate grade prostate carcinoma treated by radical prostatectomy
12. Estimation of tumor volume in radical prostatectomy specimens in routine clinical practice
13. Chromosomal clues to the development of prostate tumors
14. Aneuploidy and aneusomy of chromosome 7 detected by fluorescence in situ hybridization are markers of poor prognosis in prostate cancer
15. Trisomy 7: A potential cytogenetic marker of human prostate cancer progression
16. Potential markers of prostate cancer aggressiveness detected by fluorescence in situ hybridization in needle biopsies
17. Chromosome 7 abnormalities in prostate cancer detected by dual-color fluorescence in situ hybridization
18. Genetic and chromosomal alterations in prostatic intraepithelial neoplasia and carcinoma detected by fluorescence in situ hybridization
19. Interphase cytogenetics of prostatic tumor progression: Specific chromosomal abnormalities are involved in metastasis to the bone
20. Numerical abnormalities of chromosome 7 in human prostate cancer detected by fluorescence in situ hybridization (FISH) on paraffin-embedded tissue sections with centromere-specific DNA probes
21. Gain and loss of chromosomes 1, 7, 8, 10, 18 and Y in 46 prostate cancers
22. Molecular cytogenetic analysis of prostatic adenocarcinomas from screening studies: Early cancers may contain aggressive genetic features
23. Identification of genetic markers for prostate cancer progression
24. Epidermal growth factor receptors in human prostate cancer: Correlation with histological differentiation of the tumor
25. Epidermal growth factor receptor mRNA levels in human prostatic tumors and cell lines
26. Comparative analysis of epidermal growth factor receptor gene expression protein product in both benign, premalignant, and malignant prostate tissue
27. Chromosomal anomalies in prostatic intraepithelial neoplasia and carcinoma detected by fluorescence in situ hybridization
28. DNA sequence amplification in human prostate cancer identified by chromosome microdissection: Potential prognostic implications
29. Fluorescence in situ hybridization study of Her-2/neu oncogene amplification in prostate cancer
30. Correlation of p34cdc2 cyclin-dependent kinase overexpression, CD44s downregulation, and Her-2/neu oncogene amplification with recurrence in prostatic adenocarcinomas
31. Her-2/neu gene amplification status in prostate cancer by fluorescence in situ hybridization