New perspectives on nuclear transport

Annual Review of Genetics

Volumn 35, Issue , 2001, Pages 341-364

  Komeili, A ^a   O'Shea, E K ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Export receptor; Import receptor; Nuclear export; Nuclear import; RNA transport

Indexed keywords

MESSENGER RNA; RAN PROTEIN; SMALL NUCLEAR RNA; TRANSFER RNA;

CELL FUNCTION; CELL TRANSPORT; ENERGY TRANSFER; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; RNA TRANSPORT; SACCHAROMYCES CEREVISIAE; SEQUENCE ANALYSIS; XENOPUS LAEVIS;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; FORECASTING; HUMANS; NUCLEAR LOCALIZATION SIGNALS; NUCLEAR PORE; RAN GTP-BINDING PROTEIN; RIBONUCLEOPROTEINS; RNA;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE; XENOPUS LAEVIS;

EID: 0035675827     PISSN: 00664197     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.genet.35.102401.090720     Document Type: Review

References (99)

1. Identification of cytosolic factors required for nuclear location sequence-mediated binding to the nuclear envelope
2. Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors
3. The role of exportin-t in selective nuclear export of mature tRNAs
4. RanBP1 is crucial for the release of RanGTP from importin beta-related nuclear transport factors
5. RanGAP1 induces GTPase activity of nuclear Ras-related Ran
6. Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport
7. Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1
8. Nuclear export of Far1p in response to pheromones requires the export receptor Msn5p/Ste21p
9. Ran-independent pathway for export of spliced mRNA
10. Mapping interactions between nuclear transport factors in living cells reveals pathways through the nuclear pore complex
11. A look at messenger RNP moving through the nuclear pore
12. Running on Ran: Nuclear transport and the mitotic spindle
13. The nuclear exportin Msn5 is required for nuclear export of the Mig1 glucose repressor of Saccharomyces cerevisiae
14. hnRNP proteins and the biogenesis of mRNA
15. Putative ubiquitin ligase required for efficient mRNA export differentially affects hnRNP transport
16. Receptor-mediated substrate translocation through the nuclear pore complex without nucleotide triphosphate hydrolysis
17. Yeast genetics to dissect the nuclear pore complex and nucleocytoplasmic trafficking
18. Overexpression of the inositol phosphatase SopB in human 293 cells stimulates cellular chloride influx and inhibits nuclear mRNA export
19. The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs
20. CRM1 is an export receptor for leucine-rich nuclear export signals
21. Chromosomal localization of genes encoding CAN/Nup214-interacting proteins - Human CRM1 localizes to 2p16, whereas Nup88 localizes to 17p13 and is physically linked to SF2p32
22. Transport into and out of the cell nucleus
23. A novel class of RanGTP binding proteins
24. Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope
25. Transport between the cell nucleus and the cytoplasm
26. Isolation of a protein that is essential for the first step of nuclear protein import
27. An aminoacylation-dependent nuclear tRNA export pathway in yeast
28. Review: Transport of tRNA out of the nucleus-direct channeling to the ribosome?
29. Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity
30. TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus
31. Spindles get the Ran around
32. GTP hydrolysis by Ran is required for nuclear envelope assembly
33. An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B″ spliceosome proteins
34. Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells
35. Cal-reticulin is a receptor for nuclear export
36. Processing of intervening sequences: A new yeast mutant which fails to excise intervening sequences from precursor tRNAs
37. The role of the ran GTPase in nuclear assembly and DNA replication: Characterisation of the effects of Ran mutants
38. Cloning and characterization of LOS1, a Saccharomyces cerevisiae gene that affects tRNA splicing
39. The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus
40. A cap-binding protein complex mediating U snRNA export
41. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells
42. The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus
43. Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Psel/Kap121
44. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human
45. Optical recording of signal-mediated protein transport through single nuclear pore complexes
46. Ran-unassisted nuclear migration of a 97-kD component of nuclear pore-targeting complex
47. Calreticulin
48. Identification of a tRNA-specific nuclear export receptor
49. The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions
50. Significance of PIP2 hydrolysis and regulation of phospholipase C isozymes
51. Coordination of tRNA nuclear export with processing of tRNA
52. Proofreading and aminoacylation of tRNAs before export from the nucleus
53. Splicing is required for rapid and efficient mRNA export in metazoans
54. Specific binding of the karyopherin Kap121p to a subunit of the nuclear pore complex containing Nup53p, Nup59p, and Nup170p
55. Nucleo-cytoplasmic transport: The soluble phase
56. Small nuclear RNAs in messenger RNA and ribosomal RNA processing
57. A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex
58. An RNA-export mediator with an essential nuclear export signal
59. Importin beta is a mitotic target of the small GTPase Ran in spindle assembly
60. The direction of transport through the nuclear pore can be inverted
61. RNA transport
62. Transportin: Nuclear transport receptor of a novel nuclear protein import pathway
63. The NESCrm1p export pathway is not a major mRNA export route in Saccharomyces cerevisiae
64. Nucleocytoplasmic transport: The last 200 nanometers
65. PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation
66. Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation
67. Nuclear import of U snRNPs requires importin beta
68. Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins
69. The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex
70. The translocation of transportin-cargo complexes through nuclear pores is independent of both Ran and energy
71. NTF2 mediates nuclear import of Ran
72. REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus
73. The yeast nuclear pore complex: Composition, architecture, and transport mechanism
74. A distinct nuclear import pathway used by ribosomal proteins
75. The nuclear pore complex: A protein machine bridging the nucleus and cytoplasm
76. Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores
77. tRNA nuclear export in Saccharomyces cerevisiae: In situ hybridization analysis
78. Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p
79. Importin/karyopherin protein family members required for mRNA export from the nucleus
80. Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores
81. Separate nuclear import pathways converge on the nucleoporin Nup153 and can be dissected with dominant-negative inhibitors
82. The versatility of inositol phosphates as cellular signals
83. Nuclear import of Ran is mediated by the transport factor NTF2
84. Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export
85. Exportin 1 (Crm1p) is an essential nuclear export factor
86. The nuclear pore complex: From molecular architecture to functional dynamics
87. Binding of the Mex67p/Mtr2p heterodimer to FXFG GLFG, and FG repeat nucleoporins is essential for nuclear mRNA export
88. Nuclear RNA export in yeast
89. Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export
90. Ran-independent nuclear import of cyclin B1-Cdc2 by importin beta
91. Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export
92. Involvement of CRM1, a nuclear export receptor, in mRNA export in mammalian cells and fission yeast
93. Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities
94. Role of importin-beta in coupling Ran to downstream targets in microtubule assembly
95. The trials and travels of tRNA
96. A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export
97. The karyopherin kap142p/msn5p mediates nuclear import and nuclear export of different cargo proteins
98. Roles of Ran-GTP and Ran-GDP in precursor vesicle recruitment and fusion during nuclear envelope assembly in a human cell-free system
99. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans