Drug interactions in the epidural space

Acta Anaesthesiologica Belgica

Volumn 52, Issue 4, 2001, Pages 437-443

  Vercauteren, Marcel P ^b   Meert, Th F ^a   Hoffmann, V H L ^c   Adriaensen, H A ^c  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; CLONIDINE; CORTICOSTEROID; DROPERIDOL; FENTANYL DERIVATIVE; KETAMINE; MORPHINE; NEOSTIGMINE; OPIATE;

ANALGESIA; CONFERENCE PAPER; DRUG POTENTIATION; EPIDURAL ANESTHESIA; EPIDURAL SPACE; META ANALYSIS; PAIN ASSESSMENT; PHARMACODYNAMICS; SPINAL CORD DORSAL HORN; STATISTICAL ANALYSIS;

ADRENERGIC ALPHA-AGONISTS; ANALGESIA, EPIDURAL; ANALGESICS, OPIOID; ANESTHETICS, COMBINED; ANESTHETICS, LOCAL; DRUG SYNERGISM; HUMANS;

EID: 0035672482     PISSN: 00015164     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (83)

1. Camann W. R., Hartigan P. M., Gilbertson L.I., Johnson M.D., Datta S., Chloroprocaine antagonism of epidural opioid analgesia : a receptor-specific phenomenon ?, ANESTHESIOLOGY, 1990, 73, 860-863, 1990.
2. Vercauteren M., Meert T., Isobolographic analysis of the interaction between epidural sufentanil and bupivacaine in rats, PHARMACOL. BIOCH. BEHAV., 58, 237-242, 1997.
3. Cohen S. E., Tan S., White P. F., Sufentanil analgesia following cesarean section : epidural versus intravenous administration, ANESTHESIOLOGY, 68, 129-134, 1988.
4. Loper K., Ready L., Downey M., Sandler A. N., Nessly M., Rapp S., Badner N., Epidural and intravenous fentanyl infusions are clinically equivalent after knee surgery, ANESTH. ANALG., 70, 72-75, 1990.
5. Ellis D. J., Millar W. L., Reisner L. S., A randomized double - blind comparison of epidural versus intravenous fentanyl infusion for analgesia after cesarian section, ANESTHESIOLOGY, 72, 981-986, 1990.
6. Camu F., Debucquoy F., Alfentanil infusion for postoperative pain : A comparison of epidural and intravenous routes, ANESTHESIOLOGY, 75, 171-178, 1991.
7. Harbers J. B., Hasenbos M. A., Gort C., Folgering H., Dirksen R., Gielen M., Ventilatory function and continuous high thoracic epidural administration of bupivacaine withsufentanil intravenously or epidurally : a double-blind comparison, REG. ANESTH., 16, 65-71, 1991.
8. Miguel R., Barlow I., Morrell M., Scharf J., Sanusi D., Fu E., A prospective, randomized, double-blind comparison of epidural and intravenous sufentanil infusions, ANESTHESIOLOGY, 81, 346-352, 1994.
9. Chauvin M., Hongnat J. M., Mourgeon E., Lebrault C., Bellenfant F., Alfonsi P., Equivalence of postoperative analgesia with patient controlled intravenous or epidural alfentanil, ANESTH. ANALG., 76, 1251-1258, 1993.
10. Geller E., Chrubasik J., Graf R., Chrubasik S., Schulte-Monying J., A randomized double-blind comparison of epidural sufentanil versus intravenous sufentanil or epidural fentanyl analgesia after major abdominal surgery, ANESTH. ANALG., 76, 1243-1250, 1993.
11. Welchew E., Breen D., Patient controlled on-demand epidural fentanyl, ANAESTHESIA, 46, 438-441, 1991.
12. Ummenhofer W. C., Arends R. H., Shen D. D., Bernards C. M., Comparative spinal distribution and clearance kinetics of intrathecally administered morphine, fentanyl, alfentanil and sufentanil, ANESTHESIOLOGY, 92, 739-753, 2000.
13. de Leon-Casasola O. A., Parker B., Lema M. J., Harrison P., Massey J., Postoperative epidural bupivacaine-morphine therapy : experience with 4227 surgical cancer patients, ANESTHESIOLOGY, 81, 368-375, 1994.
14. Cross D. A., Hunt J. B., Feasibility of epidural morphine for postoperative analgesia in a small community hospital, ANESTH. ANALG., 72, 765-768, 1991.
15. Stenseth R., Sellevold O, Breivik H., Epidural morphine for postoperative pain : experience in 1085 patients, ACTA ANAESTHESIOL. SCAND., 29, 148-156, 1985.
16. Berti M., Fanelli G., Casati A., Lugani D., Aldegheri G., Torri G., Comparison between epidural infusion of fenanyl-bupivacaine and morphine-bupivacaine after orthopaedic surgery, CAN. J. ANAESTH., 45, 545-550, 1998.
17. Özalp G., Güner F., Kuru N., Kadiogullari N., Postoperative patient-controlled epidural analgesia with opioid-bupivacaine mixtures, CAN. J. ANAESTH., 45, 938-942, 1998.
18. Åkerman B., Arweström E., Post C., Local anesthetics potentiate spinal morphine antinociception, ANESTH. ANALG., 67, 943-948, 1988.
19. Vercauteren M., Meert T., Boersma F., Melis W., Adriaensen H., Spinal sufentanil in rats : Part II : Effect of adding bupivacaine to epidural sufentanil, ACTA ANAESTHESIOL. SCAND., 36, 245-249, 1992.
20. Asantila R., Eklund P., Rosenberg P. H., Continuous epidural infusion of bupivacaine and morphine for postoperative analgesia after hysterectomy, ACTA ANAESTHESIOL. SCAND., 35, 513-517, 1991.
21. Torda T. A., Hann P., Mills G., de Leon G., Penman D., Comparison of extradural fentanyl, bupivacaine and two fentanvl-bupivacaine containing mixtures for pain relief after abdominal surgery, BR. J. ANAESTH., 74, 35-40, 1995.
22. Badner N. H., Rumer E. J., Komar W. E., Moote C. A., Low dose bupivacaine does not improve epidural analgesia in orthopedic patients, ANESTH. ANALG., 72, 337-341, 1991.
23. Badner N. H., Komar W. E., Bupivacaine 0.1% does not improve postoperative epidural fentanyl analgesia after abdominal or thoracic surgery, CAN. J. ANAESTH., 39, 330-336, 1992.
24. Etches R., Gammer T.-L., Cornish R., Patient-controlled analgesia after thoracotomy : a comparison of meperidine with and without bupivacaine, ANESTH. ANALG., 83, 81-86, 1996.
25. Cullen M. L., Staren E. D., El-Ganzouri A., Logas W. G., Ivankovich A. D., Economou S. G., Continuous thoracic epidural infusion for analgesia after major addominal operatione : a randomized prospective double-blind study, SURGERY, 98, 719-728, 1985.
26. Logas W. G., El-Baz N., El-Ganzouri A., Cullen M., Staren E., Faber L. P., Ivankovich A. D., Continuous thoracic epidural analgesia for postoperative pain relief following thoracotomy : a randomized, prospective study, ANESTHESIOLOGY, 67, 787-791, 1987.
27. Salomäki T., Laitinen J., Vainionpää V., Nuutinen L., 0. 1% bupivacaine does not reduce the requirement for epidural fentanyl infusion after major abdominal surgery, REG. ANESTH., 20, 435-443, 1995.
28. Benzon H. T., Wong C. A., Wong H. Y., Brooke C., Wade L., The effect of lod-dose bupivacaine on postoperative epidural fentanyl analgesia and thrombelastography, ANESTH. ANALG., 79, 911-917, 1994.
29. Lee A., Simpson D., Whitfield A., Scott D. B., Postoperative analgesia by continuous extradural infusion of bupivacaine and diamorphine, BR. J. ANAESTH., 60, 845-850, 1988.
30. Dahl J. B., Rosenberg J., Hansen B. L., Hjortso N. C., Kehlet H., Differential analgesic effects of low-dose epidural morphine and morphine-bupivacaine at rest and during mobilization after major abdominal surgery, ANESTH. ANALG., 74, 362-365, 1992.
31. Mourisse J., Hasenbos M., Gielen M., Moll J., Cromheecke G., Epidural bupivacaine, sufentanil or the combination for post-thoracotomy pain, ACTA ANESTHESIOL. SCAND., 36, 70-74, 1992.
32. Badner N. H., Bhandari R., Bupivacaine 0. 125% improves continuous postoperative epidural fentanyl analgesia after abdominal or thoracic surgery, CAN. J. ANAESTH., 41, 387-392, 1994.
33. Hansdottir V., Bake B., Nordberg G., The analgesic efficacy and adverse effects of continuous epidural sufentanil and bupivacaine infusion after thoracotomy, ANESTH. ANALG., 83, 394-400, 1996.
34. Cooper D. W., Turner G., Patient controlled extradural analgesia to compare bupivacaine, fentanyl and bupivacaine with fentanyl in the treatment of postoperative pain, BR. J. ANAESTH., 70, 503-507, 1993.
35. Cooper D. W., Ryall D. M., Mc Hardy F. E., Lindsay S. L., Eldabe S. S., Patient-controlled extradural analgesia with bupivacaine, fentanyl or a mixture of both, after Caesarean section, BR. J. ANAESTH., 76, 611-615, 1996.
36. George K. A., Chisakuta A. M., Gamble J. A., Browne G. A., Thoracic epidural infusion for postoperative pain relief following abdominal aortic surgery : bupivacaine, fentanyl or a mixture of both ?, ANAESTHESIA, 47, 388-394, 1992.
37. Peach M. J., Westmore M. D., Postoperative epidural fentanyl infusion - is the addition of 0. 1% buivacaine of benefit ?, ANAESTH. INTENS. CARE, 22, 9-14, 1994.
38. Liu S., Angel J. M., Owens B. D., Carpenter R. L., Isabel L., Effects of epidural bupivacaine after thoracotomy, REG. ANESTH., 20, 303-310, 1995.
39. Vercauteren M., Hoffmann V., Van Den Berghe L., Van Boxem K., Kartawiadi S., Addition of bupivucaine to sufentanil in Patient-Controlled Epidural Analgesia after lower limb surgery in young adults : effect on analgesia and micturition, REG. ANESTH. PAIN MED., 23, 182-188, 1998.
40. De Kock M., Crochet B., Morimont C., Scholtes J. L., Intravenous or epidural clonidine for intra- and postoperative analgesia, ANESTHESIOLOGY, 79, 525-531, 1993.
41. Delaunay L., Leppert C., Dechaubry V., Levron J. C., Liu N., Bonnet F., Epidural clonidine decreases postoperative requirements of epidural fentanyl, REG. ANESTH., 18, 176-180, 1993.
42. Vercauteren M., Lauwers E., Meert T., De Hert S., Adriaensen H., Comparison of epidural sufentanil plus clonidine with sufentanil alone for postoperative pain relief, ANAESTHESIA, 45, 531-534, 1990.
43. Paech M. J., Pavy T. J., Orlikowski C. E., Evans S. F., Patient-controlled epidural analgesia in labor : the addition of clonidine to bupivacaine-fentanyl, REG. ANESTH. PAIN MED., 25, 34-40, 2000.
44. Claes B., Soetens M., Van Zundert A., Datta S., Clonidine added to bupivacaine-epinephrine-sufentanil improves epidural analgesia during childbirth, REG. ANESTH. PAIN MED., 23, 540-547, 1998.
45. Tremlett M. R., Kelly P. J., Parkins J., Hughes D., Redfern N., Low-dose clonidine infusion during labour, BR. J. ANAESTH., 83, 257-261, 1999.
46. Armand S., Langlade A., Boutros A., Lobjoit K., Monrigal C., Ramboatiana R., Rauss A., Bonnet F., Meta-analysis of the efficacy of extradural clonidine to relieve postoperative pain : an impossible task, BR. J. ANESTH., 81, 126-134, 1998.
47. Curatolo M., Petersen-Felix S., Scaramozzino P., Zbinden A. M., Epidural fentanyl, adrenaline and clonidine as adjuvants to local anaesthetics for surgical analgesia : meta-analyses of analgesia and side-effects, ACTA ANAESTHESIOL. SCAND., 42, 910-920, 1998.
48. Eisenach J. C., D'Angelo R., Taylor C., Hood D. D., An isobolographic study of epidural clonidine and fentanyl after cesarean section, ANESTH. ANALG., 79, 285-290, 1994.
49. Meert T. F., De Kock M., Interactions between the lipophilic opioid sufentanil and clonidine in rats after spinal application, ACTA ANAESTHESIOL. SCAND., 39, 527-534, 1995.
50. Vercauteren M., Vandeput D., Meert T., Adriaensen H., Patient-controlled epidural analgesia with sufentanil following caesarean section : the effect of adrenaline and clonidine admixture, ANAESTHESIA, 49, 767-771, 1994.
51. Curatolo M., Schnider T. W., Petersen-Felix S., Weiss S., Signer C., Scaramozzino P., Zbinden A. M., A direct search procedure to optimize combinations of epidural bupivacaine, fentanyl, and clonidine for postoperative analgesia, ANESTHESIOLOGY, 92, 325-337, 2000.
52. Milligan K. R., Convery P. N., Weir P., Quinn P., Connolly D., The efficacy and safety of epidural infusions of levobupivacaine with and without clonidine for postoperative pain relief in patients undergoing total hip replacement, ANESTH. ANALG., 91, 393-397, 2000.
53. Niemi G., Breivik H., Adrenaline markedly improves thoracic epidural analgesia produced by a low-dose infusion of bupivacaine, fentanyl and adrenaline after major surgery. A randomised, double-blind, cross-over study with and without adrenaline, ACTA ANAESTHESIOL. SCAND., 42, 897-909, 1998.
54. Verborgh C., Van Der Auwera D., Noorduin H., Camu F., Epidural sufentanil for postoperative pain relief : effect of adrenaline, EUR. J. ANAESTHESIOL., 5, 183-191, 1988.
55. Hasenbos M., Gielen M., Bos J., Tielbeek E., Stanton-Hicks M., Van Egmond J., High thoracic epidural sufentanil for post-thoracotomy pain : influence of epinephrine as an adjuvant - a double blind study, ANESTHESIOLOGY, 69, 1017-1022, 1988.
56. Welchew E., The optimum concentration for epidural fentanyl. A randomised double-blind comparison with and without adrenaline 1/200. 000, ANAESTHESIA, 38, 1037-1041, 1983.
57. Robertson K., Douglas M., McMorland G., Epidural fentanyl with and without epinephrine for post-cesarean section analgesia, CAN. ANAESTH. Soc. J., 32, 502-505, 1985.
58. Bromage P., Camporesi E., Durant P., Nialsen C., Influence of epinephrine as an adjuvant to epidural morphine, ANESTHESIOLOGY, 58, 257-260, 1983.
59. Naguib M., Adu-Gyamfi Y., Absood G. H., Farag H., Gyasi H. K., Epidural ketamine for postoperative analgesia, CAN. ANAESTH. Soc. J., 33, 16-21, 1986.
60. Peat S. J., Bras P., Hanna M. H., A double-blind comparison of epidural ketamine and diamorphine for postoperative analgesia, ANAESTHESIA, 44, 555-558, 1989.
61. Kirdemir P., Ozkocak I., Demir T., Gogus N., Comparison of postoperative analgesic effects of preemptively used epidural ketamine and neostigmine, J. CLIN. ANESTH., 12, 543-548, 2000.
62. Himmelseher S., Ziegler-Pithamitsis D., Argiriadou H., Martin J., Jelen-Esselborn S., Kochs E., Small-dose S(+)-ketamine reduces postoperative pain when applied with ropivacaine in epidural anesthesia for total knee arthroplasty, ANESTH. ANALG., 92, 1290-1295, 2001.
63. Wong C. S., Liaw W. J., Tung C. S., Su Y. F., Ho S. T., Ketamine potentiates analgesic effect of morphine in postoperative epidural pain control, REG. ANESTH., 21, 534-541, 1996.
64. Semple D., Findlow D., Aldridge L. M., Doyle E., The optimal dose of ketamine for caudal epidural blockade in children, ANAESTHESIA, 51, 1170-1172, 1996.
65. Chia Y. Y., Liu K., Liu Y. C., Chang H. C., Wong C. S., Adding ketamine in a multimodal patient-controlled epidural regimen reduces postoperative pain and analgesic consumption, ANESTH. ANALG., 86, 1245-1249, 1998.
66. Tan P. H., Kuo M. C., Kao P. F., Chia Y. Y., Liu K., Patient-controlled epidural analgesia with morphine or morphine plus ketamine for post-operative pain relief, EUR. J. ANAESTHESIOL., 16, 820-825, 1999.
67. Abdel-Ghaffar M. E., Abdulatif M. A., al-Ghamdi A., Mowafi H., Anwar A., Epidural ketamine reduces postoperative epidural PCA consumption of fentanyl/bupivacaine, CAN. J. ANAESTH., 45, 103-109, 1998.
68. Wong C. S., Lu C. C., Cherng C. H., Ho S. T., Pre-emptive analgesia with ketamine, morphine and epidural lidocaine prior to total knee replacement, CAN. J. ANAESTH., 44, 31-37, 1997.
69. Kucuk N., Kizilkaya M., Tokdemir M., Preoperative epidural ketamine does not have a postoperative opioid sparing effect, ANESTH. ANALG., 87, 103-106, 1998.
70. Weir P. S., Fee J. P., Double-blind comparison of extradural block with three bupivacaine- ketamine mixtures in knee arthroplasty, BR. J. ANAESTH., 80, 299-301, 1998.
71. Sinatra R. S., Sevarino F. B., Chung J. H., Graf G., Paige D., Takla V., Silverman D. G., Comparison of epidurally administered sufentanil, morphine and sufentanil-morphine combination for postoperative analgsia, ANESTH. ANALG., 72, 522-527, 1991.
72. Dottrens M., Rifat K., Morel D. R., Comparison of extradural administration of sufentanil, morphine and sufentanil-morphine combination after caesarean section, BR. J. ANAESTH., 69, 6-12, 1992.
73. Tanaka M., Watanabe S., Naito H., Optimal dose combination of epidural morphine and fentanyl for postoperative analgesia : a double-blind study, ANESTHESIOLOGY, 77, A831, 1992.
74. Hanson A., Hanson M., Matousek M., Epidural anesthesia for cesarian section, ACTA OBSTET. GYNECOL. SCAND., 63, 135-140, 1984.
75. Feldstein G. S., Waldman S. D., Allen M. L., Reversal of apparent tolerance to epidural morphine by epidural methylprednidolone, ANESTH. ANALG., 66, 264-266, 1987.
76. Joos S., The use of glucocorticoids and non-steroidal anti-infammatory drugs for preventive postsurgical pain relief. In : Van Aken H. ed., Balliere Tindall, BALLIERE'S CLINICAL ANESTHESIOLOGY : New developments in epidural and spinal drugs administration., 7, 615-40, 1993.
77. McNeill T. W., Andersson G. B., Schell B., Sinkora G., Nelson J., Lavender S. A., Epidural administration of methylprednisolone and morphine for pain after a spinal operation. A randomized, prospective, comparative study, J. BONE JOINT SURG. AM., 77, 1814-1818, 1995.
78. Meert T. F., Mesens J., Verheyen P., Noorduin H., Hydroxypropyl-beta-cyclodextrin can modulate the activity of spinally administered sufentanil, EUR. J. ANAESTHESIOL., 9, 399-409, 1992.
79. Bach V., Carl P., Ravlo O., Crawford M. E., Werner M., Potentiation of epidural opioids with epidural droperidol. A one year retrospective study, ANAESTHESIA, 41, 1116-1119, 1986.
80. Naji P., Farschtschian M., Wilder-Smith O. H., Wilder-Smith C. H., Epidural droperidol and morphine for postoperative pain, ANESTH. ANALG., 70, 583-588, 1990.
81. Wilder-Smith C., Wilder-Smith O., Farschtschian M., Naji P. Epidural droperidol reduces the side-effects and duration of analgesia of epidural sufentanil, ANESTH. ANALG., 79, 98-104, 1994.
82. Sanansilp V., Areewatana S., Tonsukchai N., Droperidol and the side effects of epidural morphine after cesarean section, ANESTH. ANALG., 86, 532-537, 1998.
83. Horta M. L., Ramos L., Goncalves Z. R., The inhibition of epidural morphine-induced pruritus by epidural droperidol, ANESTH. ANALG., 90, 638-641, 2000.