Norbormide: A calcium entry blocker with selective vasoconstrictor activity in rat peripheral arteries

Cardiovascular Drug Reviews

Volumn 19, Issue 3, 2001, Pages 226-233

  Bova, Sergio ^a,c   Cima, Lorenzo ^a   Golovina, Vera ^b   Luciani, Sisto ^a   Cargnelli, Gabriella ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c Department of Pharmacology and Anesthesiology ^*  (Italy)

Author keywords

Calcium entry blockers; Norbormide; PLC; Rat; Selective vasoconstriction

Indexed keywords

1 [2 (4 METHOXYPHENYL) 2 [3 (4 METHOXYPHENYL)PROPOXY]ETHYL] 1H IMIDAZOLE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CALCIUM; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CALPHOSTIN C; FURA 2; NORBORMIDE; PHENYLEPHRINE; PHOSPHOLIPASE C; PROTEIN KINASE C; RECEPTOR; SEROTONIN; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM ION; UNCLASSIFIED DRUG; VERAPAMIL;

ARTERY; CALCIUM CURRENT; CONCENTRATION RESPONSE; DRUG MECHANISM; HEART MUSCLE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION; TISSUE SPECIFICITY; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION;

EID: 0035672378     PISSN: 08975957     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1527-3466.2001.tb00067.x     Document Type: Review

References (19)

1. Stereochemistry of the most active racemate of norbormide, a selective rat toxicant
2. Inositol triphosphates and calcium signalling
3. Vasorelaxant properties of norbormide, a selective vasoconstrictor agent of the rat microvasculature
4. Calcium-antagonist effects of norbormide on isolated perfused heart and cardiac myocytes of guinea-pig: A comparison with verapamil
5. Signaling mechanisms for the selective vasoconstrictor effect of norbormide on the rat small arteries
6. Na/Ca exchange and tension development in vascular smooth muscle: Effect of amiloride
7. 2+ entry mechanism in rat A7r5 smooth muscle cells stimulated with low concentrations of vasopressin
8. 2+ in cultured arterial smooth muscle cells using fura 2 and digital imaging microscopy
9. Some laboratory observations on the toxicity and acceptability of norbormide to wild Rattus norvegicus and on feeding behaviour associated with sublethal dosing
10. 2+ channel blocker LOE 908
11. Calcium movements, distribution and functions in smooth muscle
12. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C
13. Stereochemistry of an inactive racemate of norbormide, a selective rat toxicant
14. Structure-activity studies with the selective rat toxicant norbormide
15. A comparative trial of norbormide and zinc phosphide against Rattus norvegicus on farms
16. Selective rat toxicant
17. The pharmacological properties of norbormide, a selective rat toxicant
18. Cardiovascular effects of norbormide
19. 2+ entry channels in endothelin-1-induced contraction of rat aorta using LOE 908 and SK&F 96365