Low molecular weight heparin inhibits tumor necrosis factor α-induced leukocyte rolling

Inflammation Research

Volumn 50, Issue 12, 2001, Pages 581-584

  Wan, M X ^b   Zhang, X W ^b   Torkvist L ^a   Thorlacius, H ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Intravital microsopy; LMWH; Microcirculation; TNF

Indexed keywords

DALTEPARIN; LOW MOLECULAR WEIGHT HEPARIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ADHESION; CELL INTERACTION; CONTROLLED STUDY; CREMASTER MUSCLE; LEUKOCYTE; LEUKOCYTE DIFFERENTIAL COUNT; LYMPHOCYTIC INFILTRATION; MALE; MICROCIRCULATION; MOUSE; NONHUMAN;

EID: 0035668019     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00000237     Document Type: Article

References (15)

1. Effect of heparin, dermatan sulfate, and related oligo-derivatives on human polymorphonuclear leukocyte functions
2. Heparin is an adhesive ligand for the leukocyte integrin Mac-1 (CD11b/CD1)
3. Suppression by intradermal administration of heparin of eosinophil accumulation but not oedema formation in inflammatory reactions in guinea-pig skin
4. Inhibitory effect of locally administered heparin on leukocyte rolling and chemoattractant-induced firm adhesion in rat mesenteric venules in vivo
5. Heparin attenuates TNT-alpha induced inflammatory response through a CD11b dependent mechanism
6. Low molecular weight heparin as adjuvant therapy in active ulcerative colitis
7. Tumor necrosis factor and Crohn's disease
8. Critical role of P-selectin-dependent rolling in tumor necrosis factor-α-induced leukocyte adhesion and extravascular recruitment in vivo
9. Leukocyte-endothelial adhesion molecules
10. An open cremaster muscle preparation for the study of blood vessels by in vivo microscopy
11. Leukocyte rolling and extravasation are severely compromised in P-selectin-deficient mice
12. Absence of trauma-induced leukocyte rolling in mice deficient in both P-selectin and intercellular adhesion molecule 1
13. Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment
14. Heparin oligosaccharides bind L- and P-selectin and inhibit acute inflammation
15. Inhibition of selectin-mediated cell adhesion and prevention of acute inflammation by nonanticoagulant sulfated saccharides - Studies with carboxyl-reduced and sulfated heparin and with trestatin A sulfate