Metabolic redirection of carbon flow toward isoleucine by expressing a catabolic threonine dehydratase in a threonine-overproducing Corynebacterium glutamicum

Applied Microbiology and Biotechnology

Volumn 57, Issue 5-6, 2001, Pages 667-673

  Guillouet, S ^a,b,c,d   Rodal, A ^a,b,c,d   An, G H ^a,b,c,d   Gorret, N ^a,b,c,d   Lessard, P ^a,b,c,d   Sinskey, A ^a,b,c,d  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b INSA   (France)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d SunMoon University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CARBON; HOMOSERINE DEHYDROGENASE; HOMOSERINE KINASE; ISOLEUCINE; PYRUVIC ACID; THREONINE; THREONINE DEHYDRATASE;

BACTERIUM;

AMINO ACID SYNTHESIS; ARTICLE; CATABOLISM; CONTROLLED STUDY; CORYNEBACTERIUM GLUTAMICUM; DATA ANALYSIS; GENE OVEREXPRESSION; GENETIC CODE; METABOLISM; NONHUMAN; PROTEIN EXPRESSION; STRAIN DIFFERENCE;

BASE SEQUENCE; BIOTECHNOLOGY; CORYNEBACTERIUM; DNA, BACTERIAL; FERMENTATION; GENE EXPRESSION; GENES, BACTERIAL; ISOLEUCINE; PLASMIDS; THREONINE; THREONINE DEHYDRATASE;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); CORYNEBACTERIUM; CORYNEBACTERIUM GLUTAMICUM; ESCHERICHIA COLI; PROKARYOTA; UNCULTURED ACTINOMYCETE;

EID: 0035667423     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-001-0829-z     Document Type: Article

References (13)

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2. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
3. Effect of inducible thrB expression on amino acid production in Corynebacterium lactofermentum ATCC 21799
4. Production of isoleucine by overexpression of ilvA in a Corynebacterium lactofermentum threonine producer
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6. Improved L-lysine yield with Corynebacterium glutamicum: Use of dapA resulting in increased flux combined with growth limitation
7. Gene structure and expression of the Corynebacterium flavum N13 ask-asd operon
8. Expression of the Escherichia coli catabolic threonine dehydratase in Corynebacterium glutamicum and its effect on isoleucine production
9. Engineering hybrid genes without the use of restriction enzymes: Gene splicing by overlap extension
10. Glucose-controlled L-isoleucine fed-batch production with recombinant strains of Corynebacterium glutamicum
11. Corynebacteria, Brevibacteria
12. Leucine synthesis in Corynebacterium glutamicum: Enzyme activities, structure of leuA, and effect of leuA inactivation on lysine synthesis
13. Molecular analysis and characterization of a broad-host-range plasmid, pEP2