Peptide linkers lead to modification of liver metabolism and improved tumor targeting of copper-67-labeled antibody fragments

Cancer Biotherapy and Radiopharmaceuticals

Volumn 16, Issue 6, 2001, Pages 469-481

  Novak Hofer, I ^a   Zimmermann, K ^a   Schubiger, P A ^a  

^a PAUL SCHERRER INSTITUTE   (Switzerland)

Author keywords

67 Cu; Antibody Fragments; Peptide Linkers; Radioimmunotherapy

Indexed keywords

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; ANTIBODY; ANTIBODY CONJUGATE; CHELATING AGENT; COPPER 67; COPPER COMPLEX; IMMUNOGLOBULIN F(AB) FRAGMENT; PEPTIDE; TRIGLYCINE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHELATION; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG PROTEIN BINDING; DRUG STABILITY; DRUG TISSUE LEVEL; DRUG UPTAKE; LIVER HOMOGENATE; LIVER METABOLISM; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN DEGRADATION; RADIATION EXPOSURE; RADIOACTIVITY; RADIOIMMUNOTHERAPY; XENOGRAFT;

EID: 0035667003     PISSN: 10849785     EISSN: None     Source Type: Journal    
DOI: 10.1089/10849780152752074     Document Type: Article

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