Three soluble form messages of murine CD46 are produced through alternative mRNA splicing

Journal of Biochemistry

Volumn 130, Issue 6, 2001, Pages 841-848

  Tsujimura, Akira ^a,b   Nunoue, Kou ^a,c   Inoue, Naokazu ^a,b   Shida, Kyoko ^a   Kurita Taniguchi, Mitsue ^a   Matsumoto, Misako ^a   Nomura, Midori ^a   Takeya, Tatsuo ^c   Seya, Tsukasa ^a,c  

^a Osaka Medical Center for Cancer   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

Complement regulatory protein; Mouse membrane cofactor protein (CD46); Short consensus repeats (SCR); Soluble isoforms; Transcriptome

Indexed keywords

COMPLEMENT REGULATORY PROTEIN; COMPLEMENTARY DNA; MEMBRANE COFACTOR PROTEIN; MESSENGER RNA; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ANIMAL TISSUE; ARTICLE; COMPLEMENT INHIBITION; CONTROLLED STUDY; IMMUNOREGULATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PROTEIN DETERMINATION; RABBIT; SIGNAL TRANSDUCTION; TESTIS CELL; TISSUE DISTRIBUTION;

ANIMALIA; INSERTION SEQUENCES; MURINAE; ORYCTOLAGUS CUNICULUS;

EID: 0035666452     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a003056     Document Type: Article

References (31)

1. Purification and characterization of a membrane protein (gp 45-70) which is a cofactor for cleavage of C3b and C4b
2. Membrane cofactor protein (MCP or CD46): Newest member of the regulators of complement activation gene cluster
3. CD46-mediated measles virus entry: A first key to host-range specificity
4. CD46 is a cellular receptor for human herpesvirus 6
5. Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus
6. Cell signaling by the type IV pili of pathogenic Neisseria
7. Molecular cloning of murine homologue of membrane cofactor protein (MCP, CD46): Preferential expression in testicular germ cells
8. Membrane and secretory forms of mouse membrane cofactor protein (CD46) generated from a single gene through alternative splicing
9. Mechanism of gene regulation of membrane cofactor protein (CD46) in mice: Identification and characterization of a silencer regulatory element in the 3′-flanking region of the murine CD46 gene
10. Mouse complement regulatory protein CRRY/P65 utilizes the specific mechanisms of both human decay-accelerating factor (DAF) and membrane cofactor protein (MCP)
11. Functional properties of allotypes of mouse complement regulatory protein, factor H: Difference of compatibility of each allotype with factor I of other species
12. Regulatory proteins for the activated third and fourth components of complement (C3b and C4b) in mice. I. Isolation and characterization of facfor H: The serum cofactor for the C3b/C4b inactivator (factor I)
13. Purification and characterization of mouse serum protein with specific binding affinity for C4 (Ss protein)
14. Molecular cloning and chromosomal localization of the mouse decay-accelerating factor genes; duplicated genes encodes glycosylphosphatidylinositol-anchored and transmembrane forms
15. The evolution of mouse and human complement C3-binding proteins: Divergence of form but conservation of function
16. Regulatory proteins for the activated third and fourth components of complement (C3b and C4b) in mice. II. Identification and properties of complement receptor type 1 (CR1)
17. Production of murine CD46 by cytomegalovirus infection: A viral strategy for circumvention of host complement attack by sharing a CMV-responsive element in the CD46 promoter region
18. CD46 (membrane cofactor protein (MCP) of complement, measles virus receptor): Structural and functional divergence among species
19. Molecular cloning and functional characterization of chicken Toll-like receptors
20. A novel chicken membrane-associated complement-regulatory protein: Molecular cloning and functional characterization of a chicken membrane SCR protein
21. Human complement regulators: A major target for pathogenic microorganisms
22. Altered expression of host-encoded complement regulators on human cytomegalovirus-infected cells
23. Polymorphism and proteolytic fragments of granulocyte membrane cofactor protein (MCP, CD46) of complement
24. Molecular cloning of guinea pig membrane cofactor protein: Preferential expression in testis
25. A novel isoform of human membrane cofactor protein (CD46) mRNA generated by intron retention
26. Inhibition of the complement cascade by the major secretory protein of vaccinia virus
27. Complement control proteins CD46, CD55, and CD59, as common surface constituents of human and simian immunodeficiency viruses and possible targets for vaccine protection
28. Human immunodeficiency virus type 1 incorporates both glycosyl phosphatidylinositolanchored CD55 and CD59 and integral membrane CD46 at levels that protect from complement-mediated destruction
29. Host cell-derived complement control proteins CD55 and CD59 are incorporated into the virions of two unrelated enveloped viruses. Human T cell leukemia/lymphoma virus type I (HTLV-I) and human cytomegalovirus (HCMV)
30. Extracellular enveloped vaccinia virus is resistant to complement because of incorporation of host complement control proteins into its envelope