Effects of melatonin on oxidation injury and on expression of P53 protein during ischemia-reperfusion in brain tissue of rats

Chinese Journal of Pharmacology and Toxicology

Volumn 15, Issue 6, 2001, Pages 418-422

  Li, L H ^a   Ku, B S ^a   Rao, Y ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Cerebral ischemia; Glutathione peroxidase; Hippocampus; Malondialdehyde; Melatonin; Protein P53; Reperfusion injury; Superoxide dismutase

Indexed keywords

ANTIOXIDANT; DNA; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; MELATONIN; PROTEIN P53; SUPEROXIDE DISMUTASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN PROTECTION; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; ENZYME ACTIVITY; HIPPOCAMPUS; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY;

EID: 0035665716     PISSN: 10003002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Melatonin rescues dopamine neurons from cell death in tissue culture models of oxidative stress
2. Melatonin is protective against MPTP-induced striatal and hippocampal lesions
3. Apoptosis and protein expression after focal cerebral ischemia in rat
4. Melatonin: A potent endogenous hydroxyl radical scavenger
5. Melatonin protects neurons from singlet oxygen-induced apoptosis
6. Neurohormone melatonin prevents cell damage: Effect on gene expression for antioxidant enzymes
7. Increased brain damage after stroke or excitotoxic seizures in melatonin-deficient rats
8. Melatonin administration protects CA1 hippocampal neurons after transient forebrain ischemia in rats
9. Damage, repair, and mutagenesis in nuclear genes after mouse forebrain ischemia-reperfusion
10. P53-Immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats
11. Participation of p53-protein in the cellular response to DNA damage