Excretion and metabolism of desogestrel in healthy postmenopausal women

Journal of Steroid Biochemistry and Molecular Biology

Volumn 78, Issue 5, 2001, Pages 471-480

  Verhoeven, C H J ^a   Gloudemans, R H M ^a   Peeters, P A M ^a   Van, J J ^b   Verheggen, F T M ^b   Groothuis, G M M ^c   Rietjens, I M C M ^d   Vos, R M E ^a  

^a NV Organon ^*  (Netherlands)

^b PRA International USA   (Netherlands)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

^d WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Desogestrel; Metabolism; Postmenopausal women

Indexed keywords

CARBON 14; DESOGESTREL; ETHINYLESTRADIOL; ORAL CONTRACEPTIVE AGENT;

ARTICLE; CONTROLLED STUDY; DRUG EXCRETION; DRUG METABOLISM; FECES; FEMALE; HORMONE SUBSTITUTION; HUMAN; HUMAN EXPERIMENT; INTESTINE MUCOSA; LIVER MICROSOME; LIVER MITOCHONDRION; NORMAL HUMAN; POSTMENOPAUSE; RADIOACTIVITY; SPECIES DIFFERENCE; URINARY EXCRETION;

ADMINISTRATION, ORAL; ANIMALS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DESOGESTREL; DOGS; ESTROGEN REPLACEMENT THERAPY; FECES; FEMALE; GLUCURONIDES; HUMANS; HYDROXYLATION; INTESTINAL MUCOSA; LIVER; MENOPAUSE; MOLECULAR STRUCTURE; PROGESTERONE CONGENERS; RATS; SPECIES SPECIFICITY;

CANIS FAMILIARIS;

EID: 0035663384     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(01)00124-8     Document Type: Article

References (16)

1. Metabolism of a new synthetic progestogen, Org 2969, in female volunteers. Pharmacokinetics after an oral dose
2. Serum levels of 3-keto-desogestrel after administration of desogestrel and 3-keto-desogestrel
3. Plasma concentration of 3-keto-desogestrel after oral administration of desogestrel and intravenous administration of 3-keto-desogestrel
4. Metabolism of a new synthetic progestagen, Org 2969, by human liver in vitro
5. Metabolism of the contraceptive steroid desogestrel by the intestinal mucosa
6. Metabolism of the contraceptive steroid desogestrel by human liver in vitro
7. Biological effects of a new and potent progestagen. A clinical study
8. In vitro and in vivo metabolism of desogestrel in several species
9. Metabolism of a new synthetic progestagen, Org 2969, in female volunteers The distribution and excretion of radioactivity after an oral dose of the labelled drug
10. Isolation and characterization of a novel cDNA encoding a human UGP-glucuronosyl transferase activity on C19 steroids
11. The regio- and stereo-selectivity of C19 and C21 hydroxysteroid glucuronidation by UGT2B7 and UGT2B11
12. Identification and measurement by gas chromatography-mass spectrometry of norethindrone and metabolites in human urine and blood
13. Excretion and stereoselective biotransformation of DL-, D- and L-norgestrel in women
14. The presence of DL-, D- and L-norgestrel and their metabolites in the plasma of women
15. Pharmacokinetics and biotransformation of gestodene in man
16. Metabolism of radioactive 17α-ethinyl oestradiol by women