The role of glycation in the pathogenesis of diabetic polyneuropathy

Journal of Clinical Pathology - Molecular Pathology

Volumn 54, Issue 6, 2001, Pages 400-408

  King, R H M ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

Diabetes mellitus; Glycation; Peripheral nerve

Indexed keywords

ALDOSE REDUCTASE INHIBITOR; GLUCOSE;

BLOOD VESSEL INJURY; CELL METABOLISM; CONNECTIVE TISSUE; DIABETES CONTROL; DIABETIC NEUROPATHY; DISEASE ASSOCIATION; DRUG DESIGN; DRUG TARGETING; GLUCOSE BLOOD LEVEL; GLYCATION; HUMAN; HYPERGLYCEMIA; NERVE FIBER REGENERATION; NERVE FIBER TRANSPORT; NERVE INJURY; NEUROPATHOLOGY; PRIORITY JOURNAL; REVIEW;

ANIMALS; AXONS; BASEMENT MEMBRANE; BLOOD VESSELS; CALMODULIN; COLLAGEN TYPE IV; DIABETIC NEUROPATHIES; EXTRACELLULAR MATRIX; GANGLIA, SPINAL; GAP-43 PROTEIN; GLUCOSE; HUMANS; MICROSCOPY, ELECTRON; NEURONS; PERIPHERAL NERVES; RADIAL NERVE; SCHWANN CELLS;

EID: 0035662674     PISSN: 13668714     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (108)

1. The effect of intensive treatment for diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
2. Intensified multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: The Steno type 2 randomised study
3. Myelinated fibre regeneration in diabetic sensory polyneuropathy: Correlation with type of diabetes
4. Nonenzymatic glycosylation of human serum albumin alters its conformation and function
5. Pentosidine: A molecular marker for the cumulative damage to proteins in diabetes, aging, and uremia
6. The advanced glycation end-product, Nε-(carboxymethyl)lysine, is a product of both lipid peroxidation and glycoxidarion reactions
7. Non-enzymatic glycation of peripheral nerve proteins in human diabetics
8. Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy
9. Lilly lecture 1993. Glycation and diabetic complications
10. Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes
11. Glycation products and the pathogenesis of diabetic complications
12. High glucose and DNA damage in endothelial cells
13. Increased permeability across the blood-nerve barrier of albumin glycated in vitro and in vivo from patients with diabetic polyneuropathy
14. Direct immunofluorescence findings in peripheral nerve from patients with diabetic neuropathy
15. Trapped immunoglobulins on peripheral nerve myelin from patients with diabetes mellitus
16. Excessive nonenzymatic glycosylation of peripheral and central nervous system myelin components in diabetic rats
17. The morbid anatomy of diabetic neuropathy
18. Severe sensory-autonomic neuropathy and endocrinopathy in insulin-dependent diabetes
19. Reduced perikaryal volume of lower motor and primary sensory neurons in early experimental diabetes
20. Progressive centripetal degeneration of axons in small fibre diabetic neuropathy
21. The spatial distribution of fiber loss in diabetic polyneuropathy suggests ischaemia
22. Permeation of proteins from the blood into peripheral nerves and ganglia
23. Studies on vascular permeability in peripheral nerves. 4. Distribution of intravenously injected protein tracers in the peripheral nervous system of various species
24. Dorsal root ganglia microenvironment of female BB Wistar diabetic rats with mild neuropathy
25. Nonenzymatic glycation of peripheral and central nervous system proteins in experimental diabetes mellitus
26. Effects of aminoguanidine on peripheral nerve function and polyol pathway metabolites in streptozotocin-diabetic rats
27. Effects of nonenzymatic glycosylation of extracellular matrix components on cell survival and sensory neurite extension in cell culture
28. Radical ageing in Alzheimer's disease
29. Detection of an Amadori product, 1-hexitol-lysine, in the anterior horn of the amyotrophic lateral sclerosis and spinobulbar muscular atrophy spinal cord: Evidence for early involvement of glycation in motoneuron diseases
30. Structural and functional consequences of increased tubulin glycosylation in diabetes mellitus
31. Glycation of brain actin in experimental diabetes
32. Axonal transport in diabetic neuropathy
33. Axonal transport in early experimental diabetes
34. Axonal transport in rats after galactose feeding
35. Axonal transport of protein in motor fibers of experimentally diabetic rats - Fast anterograde transport
36. The spontaneously diabetic BB Wistar rat: Morphologic and physiologic studies of peripheral nerve
37. Diabetes affects retrograde but not anterograde transport of sciatic nerve phosphofructokinase in Sprague-Dawley rats
38. Role of neurotrophins in diabetic neuropathy and treatment with nerve growth factors
39. Insulin-like growth factor (IGF) gene expression is reduced in neural ussues and liver from rats with non-insulin-dependent diabetes mellitus, and IGF treatment ameliorates diabetic neuropathy
40. Defects of axonal transport in diabetes mellitus - A possible contribution to the etiology of diabetic neuropathy
41. Retrograde axonal transport: A possible role in the development of neuropathy
42. Nonenzymatic glycosylation of peripheral nerve protein in diabetes mellitus
43. Delayed nerve regeneration in streptozotocin diabetic rats
44. Abnormal nerve regeneration in galactose neuropathy
45. Regulation of calmodulin binding to P-5777
46. Identification and characterization of the calmodulin-binding domain of neuromodulin, a nonspecifc calmodulin-binding protein
47. Dephosphorylation of protein kinase C phosphorylated B-50/GAP-43 by the calmodulin-dependent phosphatase calcineurin
48. Depletion of 43-kD growth-associated protein in primary sensory neurons leads to diminished formation and spreading of growth cones
49. Posttranslational membrane attachment and dynamic fatty acetylation of a neuronal growth cone protein, GAP-43
50. Ultrastructural evidence for the lack of co-transport of B-50/GAP-43 and calmodulin in myelinated axons of the regenerating rat sciatic nerve
51. The growth-associated protein GAP-43 appears in dorsal root ganglion cells and in the dorsal horn of the rat spinal cord following peripheral nerve iniury
52. Altered GAP-43 immunoreactivity in regenerating sciatic nerve of diabetic rats
53. Versuche zum Studium der histologischen Degeneration und Regeneration verletzer Nerven, ihre Anordnung und ihre Ergebnisse
54. Degenerative changes in rat dorsal roots during Wallerian degeneration
55. Changes in the endoneurial sheaths of peripheral nerve fibres during Wallerian degeneration
56. Basement membrane reduplication and pericyte degeneration precede development of diabetic polyneuropathy and are associated with its severity
57. Diabetic neuropathy: Abnormalities of Schwann cell and perineurial basal laminae. Implications for diabetic vasculopathy
58. Altered cellular interactions between endothelial cells and nonenzymatically glucosylated laminin/type IV collagen
59. Effects of matrix glycation on mesangial cell adhesion, spreading and proliferation
60. Alterations in human glomerular epithelial cells interacting with nonenzymatically glycosylated matrix
61. Nonenzymatic glycosylation of laminin and the laminin peptide CIKVAVS inhibits neurite outgrowth
62. Reduced susceptibility of nonenzymatically glucosylated glomerular basement membrane to proteases: Is thickening of diabetic glomerular basement membranes due to reduced proteolytic degradation?
63. The extracellular matrix of peripheral nerve in diabetic polyneuropathy
64. Scanning force microscopy reveals structural alterations in diabetic rat collagen fibrils: Role of protein glycation
65. Basic behavior of migratory Schwann cells in peripheral nerve regeneration
66. Extracellular matrix molecules and their receptors: Functions in neural development
67. Organization of point contacts in neuronal growth cones
68. Extracellular matrix and neurite outgrowth
69. 4 proteoglycan by heparin from glomeruli of streptozotocin-induced diabetic rats
70. Effects of nonenzymatic glycosylation of mesangial matrix on proliferation of mesangial cells
71. Schwann cells use a novel mechanism for fibronectin fibril assembly
72. The effect of nonenzymatic glycosylation on the binding of the main noncollagenous NC1 domain to type IV collagen
73. Heparin type IV collagen interactions: Equilibrium binding and inhibition of type IV collagen self-assembly
74. The effect of nonenzymatic glucosylation on cell and heparin-binding microdomains from type IV collagen and laminin
75. Immunocytochemical localization of a cell adhesion molecule, integrin alpha 5 beta 1, in nerve growth cones
76. Axonal regulation of Schwann cell integrin expression suggests a role for alpha 6 beta 4 in myelination
77. Association of cell surface proteoglycans of Schwann cells with extracellular matrix proteins
78. Migration of Schwann cells and regeneration of peripheral nerves
79. Localization of focal adhesion kinase in differentiating Schwann cell cultures
80. Comparison of neurite outgrowth induced by intact and injured sciatic nerves: A confocal and functional analysis
81. Localization of laminin B1 mRNA in retinal ganglion cells by in situ hybridization
82. Up-regulation of laminin B2 gene expression in dorsal root ganglion neurons and nonneuronal cells during sciatic nerve regeneration
83. Laminin alterations after in vitro nonenzymatic glycosytation
84. Proteoglycans as modulators of growth factor activities
85. Degradation of glomerular basement membrane in diabetes. 1. Susceptibility of diabetic and nondiabetic basement membrane to proteolytic degradation of isolated glomeruli
86. A comparison of perineurial and vascular basal laminal changes in diabetic neuropathy
87. Human diabetic perineurial cell basement membrane thickening
88. Perineurial calcification
89. Hypertrophic changes in diabetic neuropathy
90. The expression of B-50/GAP-43 in Schwann cells is upregulated in degenerating peripheral nerve stumps following nerve injury
91. The neuronal growth-associated protein GAP 43 induces filopodia in non-neuronal cells
92. Terminal Schwann cells elaborate extensive processes following denervation of the motor endplate
93. Changes of Schwann cell antigenic profile after peripheral nerve injury
94. Phenotypic and proliferative properties of Schwann cells from nerves of diabetic patients
95. Increased vulnerability to demyelination in streptozotocin diabetic rats
96. Accumulation of diabetic rat peripheral nerve myelin by macrophages increases with the presence of advanced glycosylation endproducts
97. Sural nerve morphometry in diabetic autonomic and painful sensory neuropathy
98. Does axonal atrophy precede segmental demyelination in human diabetic neuropathy?
99. No evidence for axonal atrophy in human diabetic polyneuropathy
100. Multifocal fiber loss in proximal sciatic nerve in symmetric distal diabetic neuropathy
101. Fiber loss is primary and multifocal in sural nerves in diabetic polyneuropathy
102. Pattern of myelinated fibre loss in the sural nerve in neuropathy related to type 1 (insulin-dependent) diabetes
103. Capillary number and percentage closed in human diabetic sural nerve
104. Morphometry of endoneurial capillaries in diabetic sensory and autonomic neuropathy
105. Diabetic neuropathy: A clinical and histological study on the significance of vascular affections
106. Étude ultrastructurale du neff périphérique chez 16 diabétiques sans neuropathie clinique. Comparaisons avec 16 neuropathies diabétiques et 16 neuropathies non diabetiques
107. Accelerated age-related browning of human collagen in diabetes mellitus
108. Pathogenesis of diabetic retinopathy