New 2-(2′-phenyl-9′-benzyl-8′-azapurin-6′-ylamino)- carboxylic acid methylesters as ligands for A1 adenosine receptors

Farmaco

Volumn 56, Issue 12, 2001, Pages 929-931

  Biagi, Giuliana ^a   Giorgi, Irene ^a   Pacchini, Federica ^a   Livi, Oreste ^a   Scartoni, Valerio ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

8 Azaadenines; A1 adenosine receptor antagonists

Indexed keywords

ADENINE DERIVATIVE; ADENOSINE A1 RECEPTOR; CARBOXYLIC ACID DERIVATIVE; LIGAND; 8 AZAADENINE; 8-AZAADENINE; ADENINE; ADENOSINE RECEPTOR; DRUG DERIVATIVE; ESTER; PURINE DERIVATIVE;

ARTICLE; DRUG BINDING; DRUG SOLUBILITY; DRUG SYNTHESIS; LIPOPHILICITY; NONHUMAN; ANIMAL; BRAIN CORTEX; CATTLE; CHEMISTRY; MEMBRANE; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RADIOASSAY; SOLUBILITY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ADENINE; ANIMALS; CATTLE; CEREBRAL CORTEX; ESTERS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANES; PURINES; RADIOLIGAND ASSAY; RECEPTORS, PURINERGIC P1; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035661154     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(01)01162-4     Document Type: Article

References (7)

1. 2-Aryl-8-azaadenosines: Structure-activity relationships in the binding with A1 and A2 receptors: A comparison with the corresponding 9-benzyl-8-azaadenines. III
2. 6-substituted 2-phenyl-8-azaadenines. Their affinity for A1 and A2 receptors. A comparison with the corresponding 2-phenyl-9-benzyl-8-azaadenosines
3. 6-substituted 2-n-butil-9-benzyl-8-azaadenines. Affinity for A1 and A2 receptors. IV
4. 6-substituted 2-phenyl-9-benzyl-8-azaadenines. Affinity for A1 and A2 receptors. A comparison with 2-n-butil analogous derivatives. V
5. 6- or N(9)-substituted 2-phenyl-8-azaadenines: Affinity for A1 receptors
6. 6-substituted 2-phenyl-N(9)-benzyl-8-azaadenines
7. A facile "one pot" synthesis of 2,9-disubstituted 8-azapurin-6-ones (3,5-disubstituted 7-hydroxy-3-H-1,2,3-triazolo[4,5-d]pyrimidines)