A chronic inhalation toxicity/oncogenicity study of methylethylketoxime in rats and mice

Inhalation Toxicology

Volumn 13, Issue 12, 2001, Pages 1093-1116

  Newton, P E ^a   Wooding, W L ^a   Bolte, H F ^a   Derelanko, M J ^a   Hardisty, J F ^a   Rinehart, W E ^a  

^a MPI RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 BUTANONE; METHEMOGLOBIN; METHYLETHYLKETOXIME; UNCLASSIFIED DRUG;

ADENOMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT INJURY; CARCINOGENICITY; CATARACT; CHRONIC TOXICITY; CONTROLLED STUDY; CORNEA DYSTROPHY; EXTRAMEDULLARY HEMATOPOIESIS; GRANULOMATOUS INFLAMMATION; HEPATOMEGALY; INTOXICATION; LEUKEMIA; LIVER CELL CARCINOMA; LIVER NECROSIS; LONG TERM EXPOSURE; MOUSE; NONHUMAN; OLFACTORY EPITHELIUM; PRIORITY JOURNAL; RAT; RETICULOENDOTHELIAL NEOPLASM; RETICULOENDOTHELIAL SYSTEM; SPLENOMEGALY; WEIGHT GAIN;

ADMINISTRATION, INHALATION; ANIMALS; ATMOSPHERE EXPOSURE CHAMBERS; BODY WEIGHT; BRAIN; BUTANONES; CARCINOGENICITY TESTS; CARCINOGENS; FEMALE; MALE; MICE; NASAL CAVITY; NEOPLASMS, EXPERIMENTAL; ORGAN SIZE; OXIMES; RATS; RATS, INBRED F344; SURVIVAL ANALYSIS;

ANIMALIA;

EID: 0035658288     PISSN: 08958378     EISSN: None     Source Type: Journal    
DOI: 10.1080/08958370152647636     Document Type: Article

References (24)

1. Tests for linear trends in proportions and frequencies
2. Toxicity of hydroxylamine sulfate following dermal exposure: Variability with exposure method and species
3. A multiple comparison procedure for comparing several treatments with a control
4. Liver
5. Experimental studies on methyl-ethyl-ketoxime toxicity
6. Nasal diagrams: A tool for recording the distribution of nasal lesions in rats and mice
7. Nasal lesion distribution and toxicity in the squamous epithelial region
8. Mapping of lesions in the nose provides insight into the mechanism of action of nasal toxicants
9. Guidelines for simple, sensitive significance tests for carcinogenic effects in long-term animal experiments
10. Influence of viral infections on body weight, survival, and tumor prevalence of B6C3F1 (C57BL/GNXC3H/ Hen) mice in carcinogenicity studies
11. Histological sectioning of the rodent larynx for inhalation toxicity testing
12. Assessing the neurotoxic potential of methyl ethyl ketoxime in rats
13. The effect of body weight on tumor incidence and carcinogenicity testing in B6C3F1 mice and F344 rats
14. Spleen, lymph nodes, and thymus
15. Trend and homogeneity analyses of proportions and life table data
16. Reproductive toxicity evaluation of methylethyl ketoxime by gavage in CD rats
17. Methyl ethyl ketoxime; proposed test rule and proposed pharmacokinetic test guideline
18. Methyl ethyl ketoxime; final test rule
19. Histopathologic examination of the rat nasal cavity