The significance of prior mechanical therapy for changes of periodontal status achieved by local delivery of a doxycyclinehyclate containing gel

Journal of Clinical Periodontology

Volumn 28, Issue 12, 2001, Pages 1115-1120

  Wolinsky, Lawrence E ^a,e   Camargo, Paulo M ^a   Polson, Alan ^b   Ryder, Mark ^c   Garrett, Steven ^d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d QLT Inc   (United States)

^e UCLA SCHOOL OF DENTISTRY   (United States)

Author keywords

Clinical study; Controlled release; Doxycycline hyclate; Local delivery; Periodontitis

Indexed keywords

DELAYED ACTION PREPARATIONS; DOXYCYCLINE; DOXYCYCLINE HYCLATE; DRUG DERIVATIVE; TETRACYCLINE DERIVATIVE;

ADULT; AGED; ANALYSIS OF VARIANCE; ARTICLE; DELAYED RELEASE FORMULATION; GEL; HUMAN; PERIODONTICS; PERIODONTITIS; PREVENTIVE DENTISTRY; RETROSPECTIVE STUDY; TIME; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ADULT; AGED; ANALYSIS OF VARIANCE; ANTIBIOTICS, TETRACYCLINE; DELAYED-ACTION PREPARATIONS; DENTAL SCALING; DOXYCYCLINE; GELS; HUMAN; MIDDLE AGE; PERIODONTAL INDEX; PERIODONTAL POCKET; RETROSPECTIVE STUDIES; SUPPORT, NON-U.S. GOV'T; TIME FACTORS;

EID: 0035656349     PISSN: 03036979     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-051x.2001.281205.x     Document Type: Article

References (18)

1. Badersten, A., Nilveus, R. & Ebelberg, J. (1984) Effect of non-surgical periodontal therapy (II). Severely advanced periodontitis. Journal of Clinical Periodontology 11, 63-76.
2. Caffesse, R. G., Sweeney, P. L. & Smith, B. A. (1986) Scaling and root planing with and without periodontal flap surgery. Journal of Clinical Periodontology 13, 205-210.
3. Fleischer, H. C., Mellonig, J. T., Brayer, W. K., Gray, J. L. & Barnett, J. D. (1989) Scaling and root planing efficacy in multi-rooted teeth. Journal of Periodontology 60, 402-409.
4. Garrett, S., Johnson, L., Drisko, C. H., Adams, D., Bandt, C., Beiswanger, B., Bogle, G., Donly, K., Hallmon, W., Hancock, E., Hanes, P., Hawley, C., Kiger, R., Killoy, W., Mellonig, J., Polson, A., Raab, F., Ryder, M., Stoller, N. H., Wang, H. L., Wolinsky, L., Evans, G., Harrold, C. Q., Arnold, R., Atack, D., Fitzgerald, B., Hill, M., Isaacs, R., Nasi, H., Newell, D., MacNeil, R.L., MacNeill, S., Spolsky, V., Duke, S., Polson, A. & Southard, G. L. (1999) Two multi-center studies evaluating locally delivered doxycycline hyclate, placebo control, oral hygiene, and scaling and root planing in the treatment of periodontitis. Journal of Periodontology 70, 490-503.
5. Haffajee, A. D., Cugini, M. A., Dibart, S., Kent, Jr., R. L. & Socransky, S. S. (1997) Clinical and microbiological features of subjects with adult periodontitis who responded poorly to scaling and root planing. Journal of Clinical Periodontology 24, 767-776.
6. Haffajee, A. D. & Socransky, S. S. (1994) Microbial etiological agents of destructive periodontal diseases. Periodontology 2000 5, 78-111.
7. Harper, D. S. & Robinson, P. J. (1987) Correlation of histometric, microbial, and critical indicators of periodontal disease status before and after root planing. Journal of Clinical Periodontology 14, 190-196.
8. Hinrichs, J. E., Wolff, L. F., Pihlstrom, B. L., Schaffer, E. M., Liljemark, W. F. & Bandt, C. L. (1985) Effects of scaling and root planing on subgingival microbial proportions standardized in terms of their naturally occurring distribution. Journal of Periodontology 56, 187-194.
9. Maenusson, I., Marks, R. G., Clark, W. B., Walker, C. B., Low, S. B. & McArthur, W. P. (1991) Clinical, microbiological and immunological characteristics of subjects with "refractory" periodontal disease. Journal of Clinical Periodontology 18, 291-299.
10. Mousques, T., Listgarten, M. A. & Phillips, R. W. (1980) Effect of scaling and root planing on the composition of human subgingival microflora. Journal of Periodontal Research 15, 144-149.
11. Pedrazzoli, V., Kilian, M., Karring, T. & Kirkegaard, E. (1991) Effect of surgical and non-surgical periodontal treatment on periodontal status and subgingival microbiota. Journal of Clinical Periodontology 18, 598-604.
12. Polson, A.M., Garrett, S., Stoller, N. H., Bandt, C., Hanes, P., Killoy, W., Harrold, C. Q., Southard, G. L., Duke, S. (1997) Multi-center comparative evaluation of subgingivally delivered sanguinarine and doxycycline in the treatment of periodontitis (I). Study design, procedures, and management. Journal of Periodontology 68, 110-118.
13. Polson, A.M., Southard, G. L., Dunn, R. L., Polson, A. P., Billen, J. R. & Laster, L. L. (1995) Initial study of guided tissue regeneration in class II furcation defects after use of a biodegadable barrier. International Journal of Periodontics & Restorative Dentistry 15, 43-55.
14. Ramfjord, S. P. (1987) Maintenance care for treated periodontitis patients. Journal of Clinical Periodontology 14, 433-437.
15. Ramfjord, S. P. (1967) The Periodontal index (PDI). Journal of Periodontology 38, 602-610.
16. Sherman, P. R., Hutchens Jr., L. H., Jewson, L. G., Moriarty, J. M., Greco, G. W. & McFall Jr., W. T. (1990) The effectiveness of subgingival scaling and root planing (I). Clinical detection of residual calculus. Journal of Periodontology 61, 3-8.
17. Singletary, M. M., Crawford, J. J. & Simpson, D. M. (1982) Darkfield microscopic monitoring of subgingival bacteria during periodontal therapy. Journal of Periodonlology 53, 671-681.
18. Walker, C. B., Godowski, K. C., Borden, L., Lennon, J., Nango, S., Stone, C. & Garrett, S. (2000) The effects of sustained release doxycycline on the anaerobic flora and antibiotic resistance pattern in subgingival plaque and saliva. Journal of Periodontology 71, 768-774.