An efficient biomimetic cleavage of aziridines with nucleophiles catalyzed by β-Cyclodextrin in water

Chemistry Letters

Volumn , Issue 3, 2001, Pages 246-247

  Arjun Reddy, M ^a   Rajender Reddy, L ^a   Bhanumathi, N ^a   Rama Rao, K ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

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EID: 0035650057     PISSN: 03667022     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

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19. Typical Procedure: β-Cyclodextrin (0.0025 mole) was dissolved in distilled water (100 mL), then aziridine (0.01 mole) dissolved in acetone (1 mL) was added followed by the amine/azide (0.01 mole) in acetone (1 mL) at room temperature. Then the reaction mixture was stirred at room temperature for 24 h and the product was extracted with ethyl acetate (3 × 50 mL). The organic phase was dried over anhydrous sodium sulfate and removed in vacuum. The crude product was purified by column chromatography on silica gel (100-200 mesh) using ethyl acetate: hexane as eluent.
20. 3S (MW 374.50): C, 64.14; H, 7.00; N, 7.48; S, 8.54%. Found: C, 64.13; H, 7.24; N, 7.34; S, 8.72%.