Transforming growth factor-β1 stimulates vascular smooth muscle cell L-proline transport by inducing system A amino acid transporter 2 (SAT2) gene expression

Biochemical Journal

Volumn 360, Issue 2, 2001, Pages 507-512

  Ensenat, D ^a   Hassan, S ^a   Reyna, S V ^a   Schafer, A I ^a   Durante, W ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Amino acid transport; Cell growth; Collagen; Growth factor

Indexed keywords

AMINO ACIDS; CELLS; COLLAGEN; GENES; PH; RNA;

SMOOTH MUSCLE CELL (SMC);

MUSCLE;

2 METHYL 2 METHYLAMINOPROPIONIC ACID; AMINO ACID TRANSPORTER 3; CARRIER PROTEIN; CYCLOHEXIMIDE; DACTINOMYCIN; PROLINE; SYSTEM A AMINO ACID TRANSPORTER 2; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ARTICLE; BLOOD VESSEL INJURY; CELL GROWTH; COLLAGEN SYNTHESIS; CONCENTRATION RESPONSE; GENE EXPRESSION; HUMAN; HUMAN CELL; PH; PRIORITY JOURNAL; PROTEIN TRANSPORT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULAR SMOOTH MUSCLE;

AMINO ACID TRANSPORT SYSTEM A; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CELLS, CULTURED; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; KINETICS; MUSCLE, SMOOTH, VASCULAR; PROLINE; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUBSTRATE SPECIFICITY; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 0035626836     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3600507     Document Type: Article

References (33)

1. Comparison of the effects of various amino acids on glycogen synthesis, lipogenesis and ketogenesis in isolated rat hepatocytes
2. Proline and hepatic lipogenesis
3. Proline is required for the stimulation of DNA synthesis in hepatocyte cultures by EGF
4. Molecular cloning and expression of a high affinity L-proline transporter expressed in putative glutamatergic pathways of rat brain
5. A novel nonopioid action of enkephalins: Competitive inhibition of the mammalian brain high affinity L-proline transporter
6. The biosynthesis of collagen and its disorders
7. Mechanisms of transport of amino acids across membranes
8. Regulatory and molecular aspects of mammalian amino acid transport
9. Molecular biology of mammalian plasma membrane amino acid transporters
10. The use of N-methylation to direct route of mediated transport of amino acids
11. Cloning and functional identification of the neuronal glutamine transporter
12. Cloning and functional expression of a ATA1, a subtype amino acid transporter A, from placenta
13. +/neutral amino acid cotransport
14. Amino acid transport system A resembles system N in sequence but differs in mechanism
15. Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A
16. Structure and function of ATA3, a new subtype of amino acid transport system A, primarily expressed in the liver and skeletal muscle
17. Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel liver-specific subtype of amino acid transport system A
18. The transforming growth factor-beta family
19. Direct transfer of transforming growth factor-β1 gene into arteries stimulates fibrocellular hyperplasia
20. Production of transforming growth factor-β1 during repair of arterial injury
21. Overexpression of transforming growth factor-β1 in arterial endothelium causes hyperplasia, apoptosis, and cartilaginous metaplasia
22. Plasmin potentiates the induction of nitric oxide synthase by interleukin-1β in vascular smooth muscle
23. Platelet-derived growth factor regulates vascular smooth muscle cell proliferation by inducing cationic amino acid transporter gene expression
24. The regulation of L-proline transport by insulin-like growth factor-1 in human osteoblast-like SaOS-2 cells
25. Insulin signaling and its regulation of system A amino acid uptake in cultured rat vascular smooth muscle cells
26. Epidermal growth factor, like glucagon, exerts a short-term stimulation of alanine in rat hepatocytes
27. Serum-mediated regulation of amino acid transport in cultured chick embryo fibroblasts
28. Subcellular localization and adaptive up-regulation of the system A (SAT2) amino acid transporter in skeletal-muscle cells and adipocytes
29. Involvement of transporter recruitment as well as gene expression in the substrate-induced adapative regulation of amino acid transport system A
30. The serum concentration of active TGF-β is severely depressed in atherosclerosis
31. Antibodies against transforming growth factor-β1 suppress intimal hyperplasia in rat model
32. Soluble transforming growth factor-β type II receptor inhibits negative remodeling, fibroblast differentiation, and intimal lesion formation but not endothelial growth
33. Transforming growth factor-β1 stimulates L-arginine transport and metabolism in vascular smooth muscle cells