Comparison of omeprazole and cimetidine in healing of gastric ulcers and prevention of recurrence in horses

Equine Veterinary Education

Volumn 13, Issue 5, 2001, Pages 260-264

  Nieto, J E ^a   Spier, S J ^b   Van Hoogmoed, L ^a   Pipers, F ^c   Timmerman, B ^a   Snyder, J R ^a  

^a Dept of Surg and Radiological Sci ^*  (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0035616175     PISSN: 09577734     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-3292.2001.tb00105.x     Document Type: Review

References (41)

1. Andrews, F.M., Doherty, TJ., Blackford, J.T., Nadeau, J.A. and Saxton, A.M. (1999a) Effect of orally administered enteric-coated omeprazole on gastric acid secretion in horses. Am. J. vet. Res. 60, 929-931.
2. Andrews, F.M., Sifferman, R.L., Bernard, W., Hughes, F.E., Daurio, C.P., Alva, R. and Cox, J.L. (1999b) Efficacy of omeprazole paste in the treatment and prevention of gastric ulcers in horses. Equine vet. J., Suppl. 29, 81-86.
3. Andrews, F.M., Jenkins, C.C., Blackford, J.T., Frazier, D.L., Olovsson, S-G. and Mattsson, H. (1992) Effect of oral omeprazole on basal and pentegastrin-stimulated gastric secretion in young female horses. Equine vet. J., Suppl. 13, 80-83.
4. Baker, S.J. and Gerring, E.L. (1993) Effects of single intravenously administered doses of omeprazole and ranitidine on intragastric pH and plasma gastrin concentrations in nonfed ponies. Am. J. vet. Res. 54, 2068-2074.
5. Brunton, L.L. (1996) Agents for control of gastric acidity and treatment of peptic ulcers. In: Goodman and Gilman's The Pharmacological Basis of Therapeutics, Eds: J.G. Hardman and L.E. Limbird, McGraw Hill. pp 901-916.
6. Daurio, C.P., Holste, J.E., Andrews, F.M., Merritt, A.M., Blackford, J.T., Dolz, F. and Thompson D.R. (1999) Effect of omeprazole paste on gastric acid secretion in horses. Equine vet. J., Suppl. 29, 59-62.
7. Dieckmann, M. and Deegen, E. (1991) Stomach ulcers in the horse clinical and gastroscopic findings in 12 horses. Tierarztl. Prax. 19, 386-394.
8. Furr, M.O. and Murray, M.J. (1989) Treatment of gastric ulcers in horses with histamine type 2 receptor antagonists. Equine vet. J., Suppl. 7, 77-79.
9. Hammond, C.J., Mason, D.K. and Watkins, K.L. (1986) Gastric ulceration in mature Thoroughbred horses. Equine vet. J. 18, 284-287.
10. Haven, M.L., Dave, K., Burrow, J.A., Merrit A.M., Harris D., Zhang, D. and Hickey, G.J. (1999) Comparison of the antisecretory effects of omeprazole when administered intravenously, as acid-stable granules and as an oral paste in horses. Equine vet. J., Suppl. 29, 54-58.
11. Jenkins, C.C., Blackford, J.T., Andrews, F.M., Frazier, D.L., Mattsson, H., Olovsson, S.G. and Peterson, A. (1992) Duration of antisecretory effects of oral omeprazole in horses with chronic gastric cannulae. Equine vet. J., Suppl. 13, 89-92.
12. MacAllister, C.G. (1999) A review of medical treatment for peptic ulcer disease. Equine vet. J., Suppl. 29, 45-49.
13. MacAllister, C.G. and Sanghia, S. (1993) Effect of ranitidine on healing of experimentally induced gastric ulcers in ponies. Am. J. vet. Res. 54, 1103-1107.
14. MacAllister, C.G., Sanghia, S. and Mauromoustakos, A. (1992) Effect of a histamine H2 type receptor antagonist (WY 45, 727) on the healing of gastric ulcers in ponies. J. vet. Int. Med. 6, 271-275.
15. MacAllister, C.G., Lowerey, F., Stebbins, M., Newman, M.S. and Young, B. (1994) Transendoscopic electrocautery-induced gastric ulcers as a model for gastric healing studies in ponies. Equine vet. J. 26, 100-103.
16. MacAllister, C.G. Andrews, P.M., Hardin, L, Jenkins, C.G. Blackford, J.T., Olovsson, S.G., Sohtell, M. and Ohlin, G. (1996) The effects of orally administered omeprazole on healing of flunixin-induced gastric ulcers in young horses (abstr). Proc. Am. Coll. vet. med. Forum. 14, 736.
17. MacAllister, C.G., Sifferman, R.L., McClure, S.R., White, N.J., Vatistas, N.J., Holste, J.E., Ericcson, G.F. and Cox, J.L. (1999) Effects of omeprazole paste on healing of spontaneous gastric ulcers in horses and foals: a field trial. Equine vet. J., Suppl. 29, 77-80
18. McClure, S.R., Glikman, L.T. and Glikman, N.W. (1999) Prevalence of gastric ulcers in show horses. J. Am. vet. med. Ass. 215, 1130-1133.
19. Merrit, A.M., Burrow, J.A., Horbal, M.J., Madison, J.B. and Tran, T. (1996) Effect of omeprazole on sodium and potassium output in pentagastrin-stimulated equine gastric contents. Am. J. vet. Res. 57, 1640-1646.
20. Murray, M.J. (1992) Gastric ulceration in horses: 91 cases (1987-1990). J. Am. vet. med. Ass. 201, 117-120.
21. Murray, M.J. (1998) Gastroduodenal ulceration. In: Equine Internal Medicine, Ed: S.M. Reed and W.M. Bayly, W.B. Saunders Co., Philadelphia. pp 615-622.
22. Murray, M.J. and Grodinsky, C. (1989) Gastric ulcers in horses: a comparison of endoscopic findings in horses with and without clinical signs. Equine vet. J. 7, 68-72.
23. Murray, M.J. and Grodinsky, C. (1992) The effect of famotidine, ranitidine and magnesium hydroxide/aluminum hydroxide on gastric fluid pH in adult horses. Equine vet. J., Suppl. 11, 52-55.
24. Murray, M.J. and Schusser, G.F. (1993) Measurement of 24 h gastric pH using an indwelling pH electrode in horses unfed, fed and treated with ranitidine. Equine vet. J. 25, 417-421.
25. Murray, M.J., Schusser, G.F., Pipers, F.S. and Gross, S.J. (1996) Factors associated with gastric lesions in Thoroughbred racehorses. Equine vet. J. 25, 368-374.
26. Murray, M.J., Haven, M.L., Eichorn, E.S., Zhang, D., Eagleson, J. and Hickey, G.J. (1997) Effects of omeprazole on healing of naturally-occurring gastric ulcers in Thoroughbred racehorses. Equine vet. J. 25, 417-421.
27. Murray, M.J., Eichorn, E.S., Holste, J.E., Cox, W.B., Stainer, W.B., Cooper, W.L. and Cooper, V.A. (1999) Safety, acceptability and endoscopie findings in foals and yearling horses treated with a paste formulation of omeprazole for twenty-eight days. Equine vet. J., Suppl. 29, 67-70.
28. Orsini, J.A., Dreyfuss, D.J., Vecchione, J., Spenser, P.A. and Uhlman, R. (1991) Effects of a histamine type-2 receptor antagonist (BMY-25368) on gastric secretion in horses. Am. J. vet. Res. 52, 108-110.
29. Peterson, W.L. and Richardson, C.T. (1983) Pharmacology and side effects of drugs used to treat peptic ulcer. In: Gastrointestinal Disease: Pathophysiology, Diagnosis, Management, Eds: M.H. Sleisenger and J.S. Fordtrans, W.B. Saunders Co., Philadelphia. pp 708-725.
30. Plue, R.E., Wall, H.G., Daurio, C., Atterbery, D.K., Cox, J.L. and Wallace, D.H. (1999) Safety of omeprazole paste in foals and mature horses. Equine vet. J,. Suppl. 29, 63-66.
31. Sandin, A., Andrews, F.M., Nadeau, J.A., Doherty, T.J. and Nilsson, G. (1999) Effects of intramuscular omeprazole on gastric acid secretion in horses over a twenty-four hour period. Equine vet. J., Suppl. 29, 50-53.
32. Sanghia, S., MacAllister, C.G. and Amouzadeh, H.R., (1988) Effects of cimetidine and ranitidine on basal gastric pH, free and total acid contents in horses. Res. vet. Sci. 212, 1407-1412.
33. Sanghia, S., MacAllister, C.G. and Amouzadeh, H.R. (1989) Effects of misoprostol and omeprazole on basal gastric pH and free acid content in horses. Res. vet. Sci. 3, 350-354.
34. Smith, J.A., DeBowes, R.M., Anderson, N.V., Leipold, H.W. and Cox, J.H. (1987) Efficacy of oral ranitidine in the reduction of gastric acid output and the prevention of phenylbutazone-induced gastric ulceration in nursing foals. Proc. Am. Ass. equine Practnrs. 33, 113-127.
35. Smyth, G.B., Duran, S., Ravis, W. and Clark, C.R. (1990) Pharmacokinetic studies of cimetidine hydrochloride in adult horses. Equine vet. J. 22, 48-50.
36. Vatistas, N.J., Nieto, J.E., Snyder, J.R. and Thompson, D. (1999a) Clinical trial to determine the effect of omeprazole given once or twice daily on gastric ulceration. Equine vet. J., Suppl. 29, 87-90.
37. Vatistas, N.J., Snyder, J.R., Carlson, G., Johnson, B., Arthur, R.M., Thurmond, M., Zhou, H. and Lloyd, K.C. (1999b) Cross-sectional study of gastric ulcers of the squamous mucosa in Thoroughbred racehorses. Equine vet. J., Suppl. 29, 34-39.
38. Vatistas, N.J., Snyder, J.R., Nieto, J.E., Thompson, D., Pollmeier, M. and Holste, J. (1999c) Acceptability of a paste formulation and efficacy of high dose omeprazole in healing gastric ulcers in horses maintained in race training. Equine vet. J., Suppl. 29, 71-76
39. Vatistas, N.J., Snyder, J.R., Carlson, G., Johnson, B., Arthur, R.M., Thurmond, M. and Lloyd, K.C. (1994) Epidemiological study of gastric ulceration in the Thoroughbred racehorse: 202 horses 1992-1993. Proc. Am. Ass. equine Practnrs. 40, 125-126.
40. Vatistas, N.J., Snyder, J.R., Thurmond, M., Nieto, J., Drake, C., Johnson, B., Woliner, M. and Clonninger, A. (1997) Factors associated with development of gastric ulcers in Thoroughbred race horses. In: Gastric Ulceration in the Racing Thoroughbred Horse. PhD Thesis, University of California.
41. Zimmerman, T.W. and Schenker, S. (1985) A comparative evaluation of cimetidine and ranitidine. Ration Drug Therap. 19, 1-7.