The role of basal and myogenic factors in the transciptional activation of utrophin promoter A: Implications for therapeutic up-regulation in Duchenne muscular dystrophy

Nucleic Acids Research

Volumn 29, Issue 23, 2001, Pages 4843-4850

  Perkins, Kelly J ^a   Burton, Edward A ^a,b   Davies, Kay E ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b RADCLIFFE INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSKELETON PROTEIN; DYSTROPHIN; MESSENGER RNA; MYOGENIC FACTOR; UTROPHIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DUCHENNE MUSCULAR DYSTROPHY; GENE MAPPING; GENE OVEREXPRESSION; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; MUSCLE ATROPHY; MYOBLAST; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN MOTIF; REGULATORY MECHANISM; REPORTER GENE; SYNAPSE; TRANSCRIPTION INITIATION; TRANSGENIC MOUSE; X CHROMOSOME RECESSIVE DISORDER;

5' FLANKING REGION; ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; CELL LINE; CONSERVED SEQUENCE; CYTOSKELETAL PROTEINS; DNA-BINDING PROTEINS; HUMANS; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; MUSCLE, SKELETAL; MUSCULAR DYSTROPHY, DUCHENNE; MYOGENIC REGULATORY FACTORS; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; SP1 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR AP-2; TRANSCRIPTION FACTORS; UP-REGULATION; UTROPHIN;

EID: 0035584042     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Complete cloning of the Duchenne muscular dystrophy (DMD) cDNA and preliminary genomic organization of the DMD gene in normal and affected individuals
2. Dystrophin and dystrophin-related proteins: A review of protein and RNA studies
3. Utrophin: A potential replacement for dystrophin?
4. Amelioration of the dystrophic phenotype of mdx mice using a truncated utrophin transgene
5. Utrophin-dystrophin-deficient mice as a model for Duchenne muscular dystrophy
6. Expression of the dystrophin-related protein (utrophin) gene during mouse embryogenesis
7. Expression of the utrophin gene during myogenic differentiation
8. Immunolocalisation and developmental expression of dystrophin related protein in skeletal muscle
9. Does utrophin expression in muscles of mdx mice during postnatal development functionally compensate for dystrophin deficiency?
10. Localization of dystrophin and dystrophin-related protein at the electromotor synapse and neuromuscular junction in Torpedo marmorata
11. Dystrophin-related protein is localized to neuromuscular junctions of adult skeletal muscle
12. The dystrophin-related protein, utrophin, is expressed on the sarcolemma of regenerating human skeletal muscle fibres in dystrophies and inflammatory myopathies
13. Association of dystrophin-related protein with dystrophin-associated proteins in mdx mouse muscle
14. Reciprocal expression of dystrophin and utrophin in muscles of Duchenne muscular dystrophy patients, female DMD-carriers and control subjects
15. Molecular and functional analysis of the utrophin promoter
16. A second promoter provides an alternative target for therapeutic up-regulation of utrophin in Duchenne muscular dystrophy
17. Promoter elements and transcriptional control of the mouse acetylcholinesterase gene
18. Transcription factor repression and activation of the human acetylcholinesterase gene
19. Muscle and neural isoforms of agrin increase utrophin expression in cultured myotubes via a transcriptional regulatory mechanism
20. Sp1 and Sp3 physically interact and co-operate with GABP for the activation of the utrophin promoter
21. Noradrenergic-specific transcription of the dopamine beta-hydroxylase gene requires synergy of multiple cis-acting elements including at least two Phox2a-binding sites
22. Differences between MyoD DNA binding and activation site requirements revealed by functional random sequence selection
23. Expression of a single transfected cDNA converts fibroblasts to myoblasts
24. Developmental expression of Sp1 in the mouse
25. Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors
26. Interaction of MyoD family proteins with enhancers of acetylcholine receptor subunit genes in vivo
27. The scientific basis of myology
28. MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer
29. E-box sites and a proximal regulatory region of the muscle creatine kinase gene differentially regulate expression in diverse skeletal muscles and cardiac muscle of transgenic mice
30. Analysis of muscle creatine kinase gene regulatory elements in skeletal and cardiac muscles of transgenic mice
31. A novel site in the muscle creatine kinase enhancer is required for expression in skeletal but not cardiac muscle
32. Muscle gene E-box control elements. Evidence for quantitatively different transcriptional activities and the binding of distinct regulatory factors
33. c-myc inhibition of MyoD and myogenin-initiated myogenic differentiation
34. Developmental patterns in the expression of Myf5, MyoD, myogenin, and MRF4 during myogenesis
35. Herculin, a fourth member of the MyoD family of myogenic regulatory genes
36. Conservation of promoter sequence but not complex intron splicing pattern in human and hamster genes for 3-hydroxy-3-methylglutaryl coenzyme A reductase
37. Induction of utrophin expression by heregulin in skeletal muscle cells: Role of the N-box and GA binding protein
38. Sp1 and Sp3 regulate expression of the neuronal nicotinic acetylcholine receptor beta4 subunit gene
39. MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer
40. Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter