Cutting edge: Positive selection induced by a self-peptide with TCR antagonist activity

Journal of Immunology

Volumn 167, Issue 11, 2001, Pages 6092-6095

  Santori, F R ^a   Brown, S M ^a   Lu, Y ^a   Neubert, T A ^a   Vukmanovic S ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CELL SELECTION; CONTROLLED STUDY; GENE REARRANGEMENT; LIGAND BINDING; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; THYMUS;

EID: 0035576392     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.11.6092     Document Type: Article

References (35)

1. Selecting and maintaining a diverse T.cell repertoire
2. Role of self-peptides in positively selecting the T-cell repertoire
3. Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor
4. Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells
5. T-cell receptor affinity and thymocyte positive selection
6. A unified model for T cell recognition and thymic selection of the T cell repertoire
7. High fives of hand clasps?
8. The agonist-antagonist balance in positive selection
9. T cell receptor antagonist peptides induce positive selection
10. Specificity and flexibility in thymic selection
11. In vivo expression of a TCR antagonist: T cells escape central tolerance but are antagonized in the periphery
12. In vivo antagonism of a T cell response by an endogenously expressed ligand
13. Identification of a naturally occurring ligand for thymic positive selection
14. Specific recognition of thymic self-peptides induces the positive selection of cytotoxic T lymphocytes
15. Positive selection of an H2-M3 restricted T cell receptor
16. The selection of M3-restricted T cells is dependent on M3 expression and presentation of N-formylated peptides in the thymus
17. A naturally processed mitochondrial self-peptide in complex with thymic MHC molecules functions as a selecting ligand for a viral-specific T cell receptor
18. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules
19. Long-term T cell memory requires the surface expression of self-peptide/major histocompatibility complex molecules
20. A model for evolutionary change
21. Direct binding of peptide to empty MHC class I molecules on intact cells and in vitro
22. Enhanced intracellular dissociation of major histocompatibility complex class I-associated peptides: A mechanism for optimizing the spectrum of cell surface-presented cytotoxic T lymphocyte epitopes
23. Modulation of CD8+ T cell response to antigen by the levels of self MHC class I
24. Characterization of peptides bound to class I MHC molecule HLA-A2.1 by mass spectrometry
25. A naturally occurring peptide recognized by alloreactive CD8+ cytotoxic T lymphocytes in association with a class I MHC protein
26. Profile analysis: Detection of distantly related proteins
27. SYFPEITHI: Database for MHC ligands and peptide motifs
28. Identification of a cross-reactive self ligand in virus-mediated autoimmunity
29. Positive selection of T-lymphocytes induced by intrathymic injection of a thymic epithelial cell line
30. CD3 ligation on immature thymocytes generates antagonist-like signals appropriate for CD8 lineage commitment, independently of T cell receptor specificity
31. Modulation of T cell development by an endogenous altered peptide ligand
32. Mature T cell reactivity altered by peptide agonist that induces positive selection
33. Positive selection of CD4+ T cells is induced in vivo by agonist and inhibited by antagonist peptides
34. Antagonist peptide selects thymocytes expressing a class II major histocompatibility complex-restricted T cell receptor into the CD8 lineage
35. Appendix 5: Nomenclature for peptide fragment ions (positive ions)