Helix-coil transition of PrP106-126: Molecular dynamic study

Proteins: Structure, Function and Genetics

Volumn 45, Issue 4, 2001, Pages 382-396

  Levy, Yaakov ^a   Hanan, Eilat ^a   Solomon, Beka ^a   Becker, Oren M ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

A117V mutation; Helix coil transition; Prion protein; PrP106 126

Indexed keywords

PRION PROTEIN;

ACIDITY; ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; GENE MUTATION; HYDROPHOBICITY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTON TRANSPORT; SIMULATION;

AMINO ACID SUBSTITUTION; ANIMALS; COMPUTER SIMULATION; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROPHOBICITY; KINETICS; MODELS, MOLECULAR; MUTATION; PEPTIDE FRAGMENTS; PRIONS; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; SOLVENTS;

EID: 0035575867     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.1157     Document Type: Article

References (39)

1. Molecular biology ofprion diseases
2. Prion protein biology
3. Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform
4. Physical studies of conformational plasticity in recombinant prion protein
5. Neurotoxicity of a prion protein fragment
6. NMR structure of the mouse prion protein domain Prp(121-231)
7. NMR characterization of the full-length recombinant murine prion protein
8. Secondary structure analysis of the scrapie associated protein PrP27-30 in water by infrared spectroscopy
9. Conversion of α-helices into Β-sheets features in the formation of the scrapie prion proteins
10. Folding and function of the myelin proteins from primary sequence data
11. Solid-state NMR studies of the prion protein H1 fragment
12. Structure of the recombinant full-length hamster prion protein PrP (29-231): The N terminus is highly flexible
13. NMR solution structure of the human prion protein
14. Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid
15. Prion protein peptides induce alpha-helix to beta-sheet conformational transitions
16. Polyalaninebased peptides as models for self-associated Β-pleated-sheet complexes
17. Polypeptide chain folding in the hydrophobic core of hamster scrapie prion: Analysis by x-ray diffraction
18. Role of microglia and host prion protein in neurotoxicity of a prion protein fragment
19. Molecular characteristics of a protease-resistant, amyloidogenic and neurotoxic peptide homologous to residues 106-126 of the prion protein
20. Conformational polymorphism of the amyloidogenic and neurotoxic peptide homologous to residues 106-126 of the prion protein
21. Recombinant scrapie-like prion protein of 106 amino acids is soluble
22. Molecular determinants of the physicochemical properties of a critical prion protein region comprising residues 106-126
23. Determination of solution conformations of PrP106-126, a neurotoxic fragment of prion protein, by 1H NMR and restrained molecular dynamics
24. Theoretical studies of sequence effects on the conformational properties of a fragment of the prion protein: Implications for scrapie formation
25. CHARMM: A program for macromolecular energy, minimization and dynamic calculation
26. All-atom empirical potential for molecular modeling and dynamics studies of proteins
27. Effective energy function for proteins in solution
28. New view of protein folding reconciled with the old through multiple unfolding simulations
29. Dictionary of protein secondary structure: Pattern recognition of hydrogen-bonded and geometrical features
30. Principal coordinate maps of molecular potential energy surfaces
31. Flexibility, conformation spaces, and bioactivity
32. sc conformational change
33. Theory of the phase transition between helix and random coil
34. Molecular dynamics simulations of helix denaturation
35. Solvent effects on the energy landscapes and folding kinetics of polyalanine
36. The nonplanarity of the peptide group: Molecular dynamics simulations with a polarizable two-state model for the peptide bond
37. Internal and overall peptide group motion in proteins: Molecular dynamics simulations for lysozyme compared with results from x-ray and NMR spectroscopy
38. Role of water on unfolding kinetics of helical peptides studied by molecular dynamics simulations