Optimization of an imidate hydrolysis reaction: Use of DOE and mathematical modeling to deliver yield and productivity improvements

Organic Process Research and Development

Volumn 5, Issue 6, 2001, Pages 659-664

  Gavin, Dermot J ^a   Mojica, Carlos A ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0035566383     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op010225+     Document Type: Article

References (9)

1. (a) Pinner, A.; Klein, F. Ber. 1877, 10, 1889.
2. (b) For reviews see: Roger, R.; Neilson, D. Chem. Rev. 1961, 61, 179.
3. (a) Box, G.; Hunter, W. G.; Hunter, J. S. Statistics for Experimenters; Wiley: New York, 1978.
4. (b) Montgomery, D. C. Design and Analysis of Experiments; Wiley: New York, 1997.
5. (c) Schmidt, S. R.; Launsby, R. G. Understanding Industrial Designed Experiments; Air Academy Press: New York, 1978.
6. (d) Carlson, R. Design and Optimization in Organic Synthesis; Elsevier: New York, 2000.
7. Lenth, R. V. Quick and easy analysis of unreplicated factorials. Technometrics 1989, 31, 469.
8. Draper, N. R.; Smith, H. Applied Regression Analysis; Wiley-Interscience: New York, 1998.
9. We had the opportunity to try several commercially available software packages for experimental design and analysis. In this case both Design Expert, version 5, by Stat-Ease and Minitab, version 13.30, from Minitab Inc. were used.