Large-scale synthesis of a pyrrolo[2,3-d]pyrimidine via Dakin-West reaction and Dimroth rearrangement

Organic Process Research and Development

Volumn 5, Issue 6, 2001, Pages 581-586

  Fischer, Reto W ^a   Misun, Marian ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

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[No Author keywords available]

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EID: 0035562117     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op010041v     Document Type: Article

References (44)

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27. Safety remark: malonodinitrile decomposes autocatalytically at elevated temperatures with an adiabatic temperature rise in excess of 1000 °C! The initiation phase of the decomposition is shortened by bases. For these reasons, when performing this type of pyrrole condensation reactions on large scale, malonodinitrile should be the component being added to the sodium hydroxide solution rather than the opposite way to avoid a possible run-away reaction.
28. Bulk substance was stored in barrels which were flushed with nitrogen to avoid pyrrole oxidation.
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