Enhanced antiviral effect in cell culture of type 1 interferon and ribozymes targeting HCV RNA

Journal of Viral Hepatitis

Volumn 8, Issue 6, 2001, Pages 400-405

  Macejak, D G ^a   Jensen, K L ^a   Pavco, P A ^a   Phipps, K M ^b   Heinz, B A ^b   Colacino, J M ^b   Blatt, L M ^a  

^a Sirna Therapeutics Inc   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Hepatitis C virus; Interferon; Poliovirus chimera; Ribozyme

Indexed keywords

ALPHA2A INTERFERON; ALPHA2B INTERFERON; RECOMBINANT ALPHA2A INTERFERON; RECOMBINANT ALPHA2B INTERFERON; RIBOZYME;

ARTICLE; CELL CULTURE; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; HELA CELL; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; VIRUS INHIBITION; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; HELA CELLS; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INTERFERON ALFA-2A; POLIOVIRUS; RNA, CATALYTIC; RNA, VIRAL; TRANSFECTION; VERO CELLS; VIRUS REPLICATION;

EID: 0035553604     PISSN: 13520504     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2893.2001.00321.x     Document Type: Article

References (12)

1. Molecular biology of the hepatitis C viruses: Implications for diagnosis, development and control of viral diseases
2. Hepatitis C. The Clinical Spectrum of Disease
3. Clinical outcomes after transfusion-associated hepatitis C
4. Combination therapy with interferon plus ribavirin for the initial treatment of chronic hepatitis C
5. Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C
6. Poliovirus chimeras replicating under the translational control of genetic elements of hepatitis C virus reveal unusual properties of the internal ribosomal entry site of hepatitis C virus
7. Internal ribosome entry sites within hepatitis C virus RNA
8. Inhibition of HCV RNA-dependent translation and replication of a chimeric HCV-poliovirus using synthetic stabilized ribozymes
9. Pharmacokinetics and tissue distribution of a ribozyme directed against hepatitis C virus RNA following subcutaneous or intravenous administration in mice
10. The interferon system. A bird's eye view of its biochemistry
11. Synthesis, deprotection, analysis and purification of RNA and ribozymes
12. Chemical modification of hammerhead ribozymes. Catalytic activity and nuclease resistance