Effect of Herbal Medicine Keishi-To (TJ-45) and Its Components on Rat Pancreatic Acinar Cell Injuries in vivo and in vitro

Pancreatology

Volumn 1, Issue 2, 2001, Pages 102-109

  Motoo, Yoshiharu ^a   Su, Shi Bing ^a   Xie, Min Jue ^a   Mouri, Hisatsugu ^a   Taga, Hiromi ^a   Sawabu, Norio ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Arginine; Chronic pancreatitis; Herbal medicine; Keishi to (TJ 45); Manganese superoxide dismutase; Pancreatic acinar cell injury; Pancreatic ischemia; Pancreatitis associated protein; Saiko keishi to (TJ 10); WBN Kob rat

Indexed keywords

ARGININE; HERBACEOUS AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; KEISHI TO; KEISHI-TO; MESSENGER RNA; NITRIC OXIDE SYNTHASE; NOS2 PROTEIN, RAT; SUPEROXIDE DISMUTASE;

ANIMAL; ARTICLE; COMPARATIVE STUDY; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; INJURY; MALE; PANCREAS; PATHOLOGY; RAT; RAT STRAIN;

ANIMALS; ARGININE; DRUGS, CHINESE HERBAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MALE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PANCREAS; RATS; RATS, INBRED STRAINS; RNA, MESSENGER; SUPEROXIDE DISMUTASE; TRANSCRIPTION, GENETIC;

EID: 0035553387     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1159/000055801     Document Type: Article

References (31)

1. Singer MV, Gyr K, Sarles H: Revised classification of pancreatitis: Report of the Second International Symposium on the Classification of Pancreatitis in Marseille, France, March 28-30, 1984. Gastroenterology 1985;89:683-685.
2. Ashizawa N, Niigaki M, Hamamoto N, Niigaki M, Kaji T, Katsube T, Sato S, Endoh H, Hidaka K, Watanabe M, Kinoshita Y: The morphological changes of exocrine pancreas in chronic pancreatitis. Histol Histopathol 1999;14:539-552.
3. Onizuka S, Ito M, Sekine I, Tsunoda T, Eto T: Spontaneous pancreatitis in spontaneously hypertensive rats. Pancreas 1994;9:54-61.
4. Uchida T, Tsuchiya R, Harada N, Tsunoda T, Yamaguchi T, Eto T, Furukawa M: Ischemic changes in the pancreas of Watanabe heritable hyper-lipidemic rabbits. Int J Pancreatol 1988; 3:261-271.
5. Pitkaranta P, Kivisaari L, Nordling S, Nuutinen P, Schroder T: Vascular changes of pancreatic ducts and vessels in acute necrotizing, and in chronic pancreatitis in humans. Int J Pancreatol 1991;8:13-22.
6. Tanaka T, Ichiba Y, Miura Y, Ito H, Dohi K: Canine model of chronic pancreatitis due to chronic ischemia. Digestion 1994;55:86-89.
7. Kanoh M, Ibata H, Miyagawa M, Matsuno Y: Clinical effects of camostat in chronic pancreatitis. Biomed Res 1989;10(suppl 1):145-150.
8. Mori Y, Yokoyama J, Nishimura M, Serizawa O, Ikeda Y: Effect of camostat on pancreatic impairment in WBN/Kob rats. Biomed Res 1989;10(suppl 1):157-166.
9. Sugiyama M, Kobori O, Atomi Y, Wada N, Kuroda A, Muto T: Effect of oral administration of protease inhibitor on pancreatic exocrine function in WBN/Kob rats with chronic pancreatitis. Pancreas 1996;13:71-79.
10. Nakata K, Hosono Y, Hosono H, Sakaguchi H, Hosono S: The treatment with Kampo medicine for chronic pancreatitis (Engl abstract). Jpn J Orient Med 1986;36:25-43.
11. Wakasugi H: Kampo treatment of chronic pancreatitis (Japanese). J Clin Exp Med 1993;167: 824-829.
12. Su SB, Motoo Y, Xie MJ, Sakai J, Taga H, Sawabu N: Expression of pancreatitis-associated protein in spontaneous chronic pancreatitis in the WBN/Kob rat: Effect of herbal medicine Saiko-keishi-to (TJ-10). Pancreas 1999;19: 239-247.
13. Motoo Y, Su SB, Xie MJ, Taga H, Sawabu N: Effect of herbal medicine Saiko-keishi-to (TJ-10) on rat spontaneous chronic pancreatitis: Comparison with other herbal medicines. Int J Pancreatol 2000;27:123-129.
14. Yamashiki M, Nishimura A, Suzuki H, Sakaguchi S, Kosaka Y: Effects of the Japanese herbal medicine 'Sho-saiko-to' (TJ-9) on in vitro interleukin-10 production by peripheral blood mononuclear cells of patients with chronic hepatitis C. Hepatology 1997;25:1390-1397.
15. Kakumu S, Yoshioka K, Wakita T, Ishikawa T: Effect of TJ-9, Sho-saiko-to (a Kampo medicine), on interferon-γ and antibody productions specific to hepatitis B virus in patients with type B chronic hepatitis. Int J Immunopharmacol 1990;13:141-146.
16. Sakaida I, Matsumura Y, Akiyama S, Hayashi K, Ishige A, Okita K: Herbal medicine Sho-saiko-to (TJ-9) prevents liver fibrosis and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. J Hepatol 1998;28:298-306.
17. Shimizu I, Ma YR, Mizobuchi Y, Liu Y, Miura T, Nakai Y, Yasuda M, Shiba M, Horie T, Amagaya S, Kawada N, Hori H, Ito S: Effect of Sho-saiko-to, a Japanese herbal medicine, on hepatic fibrosis in rats. Hepatology 1999;29: 149-160.
18. Terasawa K: Yang disease, the first stage, Yang excess and corresponding prescriptions; in Kampo, Japanese-Oriental Medicine. Insight from Clinical Cases. Tokyo, KK Standard McIntyre, 1993, pp 104-106.
19. Ohashi K, Kim JH, Hara H, Aso R, Akimoto T, Narama K: WBN/Kob rats, a new spontaneously occurring model of chronic pancreatitis. Int J Pancreatol 1990;6:231-247.
20. Motoo Y, Taga K, Su SB, Xie MJ, Sawabu N: Arginine induces apoptosis and gene expression of pancreatitis-associated protein in rat pancreatic acinar AR4-2J cells. Pancreas 2000; 20:61-66.
21. Arai I, Hasegawa M, Mase A, Kitani T, Komatsu Y, Yamaura H, Sasaki K, Taguchi S: Development of pancreatic dysfunction and pathohistology in WBN/Kob rats using special breeding diet. Jpn J Appl Physiol 1997;27:373-380.
22. Su SB, Motoo Y, Xie MJ, Miyazono K, Sawabu N: Expression of transforming growth factor beta in spontaneous chronic pancreatitis in the WBN/Kob rat. Dig Dis Sci 2000;45:151-159.
23. Dobashi K, Asayama K, Kato K, Kobayashi M, Kawaoi A: Immunohistochemical localization of copper-zinc and manganese superoxide dismutase in rat tissues. Acta Histochem Cytochem 1989;22:351-365.
24. Keim V, Iovanna JL, Dagorn JC: The acute phase reaction of the exocrine pancreas: Gene expression and synthesis of pancreatitis-associated proteins. Digestion 1994;55:65-72.
25. Ortiz EM, Dusetti NJ, Vasseur S, Malka D, Bödeker H, Dagorn JC, Iovanna JL: The pancreatitis-associated protein is induced by free radicals in AR4-2J cells and confers cell resistance to apoptosis. Gastroenterology 1998;114: 808-816.
26. Czakó L, Takács T, Varga IS, Tiszlavicz L, Hai DQ, Hegyi P, Matkovics B, Lonovics J: Involvement of oxygen-derived free radicals in L-arginine-induced acute pancreatitis. Dig Dis Sci 1998;43:1770-1777.
27. Hirano T, Furuyama H, Kawakami Y, Ando K, Tsuchiya T: Cytoprotective effects of Saiko-keishi-to on the pancreas in rat cerulein-induced acute pancreatitis: Analysis of lipid peroxidation, superoxide dismutase and lysosomal enzymes in pancreatic tissues (Japanese). Kampo Med 1995;19:115-118.
28. Egashira T, Takayama F, Yamanaka Y, Komatsu Y: Monitoring of radical scavenging activity of peroral administration of Kampo medicine Sho-saiko-to in rats. Jpn J Pharmacol 1999;80:379-382.
29. Ono K, Saito E, Saeki T, Iwasaki A, Arakawa Y, Kurokawa K, Hashimoto Y: Experimental studies on the inhibitory effect of herbal medicines on gastric acid secretion (Japanese). Prog Med 1993;13:2832-2835.
30. Ueda Y, Komatsu M, Hiramatsu M: Free radical scavenging activity of the Japanese herbal medicine Toki-shakuyaku-san (TJ-23) and its effect on superoxide dismutase activity, lipid peroxides, glutamate, and monoamine metabolites in aged rat brain. Neurochem Res 1996; 21:909-914.
31. Funakoshi A, Jimi A: Prophylactic effect of Saiko-keishi-to on rat acute pancreatitis (Japanese). Clin Res 1992;69:2992-2994.