Insights from linked single nucleotide polymorphisms: What we can learn from linkage disequilibrium

Current Opinion in Genetics and Development

Volumn 11, Issue 6, 2001, Pages 647-651

  Wall, J D ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODIVERSITY; COMPARATIVE STUDY; DEMOGRAPHY; DROSOPHILA; GENE CONVERSION; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENE SEQUENCE; GENETIC MODEL; GENETIC RECOMBINATION; GENETIC VARIABILITY; HUMAN; MOLECULAR EVOLUTION; MOLECULAR MODEL; NONHUMAN; POPULATION; PRIORITY JOURNAL; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; SPECIES DIFFERENCE;

EID: 0035546130     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(00)00248-3     Document Type: Review

References (56)

1. Gene conversion and different population histories may explain the contrast between polymorphism and linkage disequilibrium levels
2. Linkage disequilibrium in the human genome
3. A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms
4. Haplotype dimorphism in a SNP collection from Drosophila melanogaster
5. Reduced X-linked nucleotide polymorphism in Drosophila simulans
6. Patterns of DNA sequence polymorphism along chromosome 1 of maize (Zea mays ssp. mays L.)
7. The power of association studies to detect the contribution of candidate genetic loci to variation in complex traits
8. Assessment of linkage disequilibrium by the decay of haplotype sharing, with application to fine-scale genetic mapping
9. Linkage disequilibrium in humans: Models and data
10. Levels of naturally occurring DNA polymorphism correlate with recombination rates in Drosophila melanogaster
11. DNA variability and recombination rates at X-linked loci in humans
12. Adjusting the focus on human variation
13. Selection, recombination, and DNA polymorphism in Drosophila
14. The hitchhiking effect on the site frequency spectrum of DNA polymorphisms
15. Properties of statistical tests of neutrality for DNA polymorphism data
16. Regions of lower crossing over harbor more rare variants in African populations of Drosophila melanogaster
17. a) regions of the Drosophila melanogaster X chromosome
18. Detecting ancient admixture in humans using sequence polymorphism data
19. A comparison of linkage disequilibrium measures for fine-scale mapping
20. Linkage disequilibrium and recombination
21. Estimating the recombination parameter of a finite population model without selection
22. A genome-wide departure from the standard neutral model in natural populations of Drosophila
23. Two-locus sampling distributions and their application
24. Why is there so little intragenic linkage disequilibrium in humans?
25. Differences in crossover frequency and distribution among three sibling species of Drosophila
26. Microsatellite variation and recombination rate in the human genome
27. Comparison of human genetic and sequence-based physical maps
28. Statistical properties of the number of recombination events in the history of a sample of DNA sequences
29. Ancestral inference from samples of DNA sequences with recombination
30. A coalescent estimator of the population recombination rate
31. Using the variance of pairwise differences to estimate the recombination rate
32. A comparison of estimators of the population recombination rate
33. Maximum likelihood estimation of recombination rates from population data
34. Estimation of population parameters and recombination rates from single nucleotide polymorphisms
35. Estimating recombination rates from population genetic data
36. Molecular and population genetic analysis of allelic sequence diversity at the human beta-globin locus
37. Crossover breakpoint mapping identifies a subtelomeric hotspot for male meiotic recombination
38. Inference in molecular population genetics
39. Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion
40. Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28
41. Extent and distribution of linkage disequilibrium in three genomic regions
42. The extent of linkage disequilibrium in four populations with distinct demographic histories
43. The effect of gene conversion on intralocus associations
44. The coalescent with gene conversion
45. Meiotic gene conversion tract length distribution within the rosy locus of Drosophila melanogaster
46. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
47. New HLA-DPB1 alleles generated by interallelic gene conversion detected by analysis of sperm
48. When did the human population size start increasing?
49. Genetic and fossil evidence for the origin of modern humans
50. Ancient differences in population size can mimic a recent African origin of modern humans
51. Genetic variation of Drosophila melanogaster natural populations
52. Historical biogeography of the Drosophila melanogaster species subgroup
53. Contrasting patterns of X-linked and autosomal nucleotide variation in Drosophila melanogaster and Drosophila simulans
54. Recombination and the frequency spectrum in Drosophila melanogaster and Drosophila simulans
55. The frequency distribution of nucleotide variation in Drosophila simulans