Available space and extracellular transport of macromolecules: Effects of pore size and connectedness

Annals of Biomedical Engineering

Volumn 29, Issue 12, 2001, Pages 1150-1158

  Yuan, Fan ^a   Krol, Ave ^a   Tong, Sheng ^a  

^a Duke University   (United States)

Author keywords

Diffusion; Drug delivery; Partition coefficient

Indexed keywords

BESSEL FUNCTIONS; CHROMATOGRAPHIC ANALYSIS; COMPUTER SIMULATION; CRYSTAL LATTICES; DRUG THERAPY; GELS; GLUCOSE; MATHEMATICAL MODELS; MOLECULAR WEIGHT; MONOMERS; PORE SIZE; PROTEINS; TISSUE; TRANSPORT PROPERTIES; TUMORS; VOLUME FRACTION;

DRUG DELIVERY; TISSUE PHANTOMS;

MACROMOLECULES;

DEXTRAN;

ACTIVE TRANSPORT; ARTICLE; ARTIFICIAL NEURAL NETWORK; BIOLOGICAL MODEL; CALIBRATION; CELL CULTURE; CHEMISTRY; COMPARATIVE STUDY; COMPUTER SIMULATION; DIFFUSION; DRUG DELIVERY SYSTEM; EXPERIMENTAL NEOPLASM; EXTRACELLULAR SPACE; HUMAN; MACROMOLECULE; METABOLISM; MOLECULAR WEIGHT; PHYSIOLOGY; POROSITY; SENSITIVITY AND SPECIFICITY;

BIOLOGICAL TRANSPORT, ACTIVE; CALIBRATION; COMPUTER SIMULATION; DEXTRANS; DIFFUSION; DRUG DELIVERY SYSTEMS; EXTRACELLULAR SPACE; HUMANS; MACROMOLECULAR SUBSTANCES; MAMMARY NEOPLASMS, EXPERIMENTAL; MODELS, BIOLOGICAL; MOLECULAR WEIGHT; NEURAL NETWORKS (COMPUTER); POROSITY; SENSITIVITY AND SPECIFICITY; TUMOR CELLS, CULTURED;

EID: 0035544745     PISSN: 00906964     EISSN: None     Source Type: Journal    
DOI: 10.1114/1.1424915     Document Type: Article

References (33)

1. Age-related changes in perimicrovascular protein distribution
2. Percolation processes - I. Crystals and mazes
3. Electron microscopic studies of cartilage proteoglycans
4. Equilibrium distribution of flexible polymer chains between a macroscopic solution phase and small voids
5. Interstitial transport of rabbit and sheep antibodies in normal and neoplastic tissues
6. Physiological function of connective tissue polysaccharides
7. Factors that influence the penetration of methotrexate through solid tissue
8. Mechanisms and thermodynamics of transcapillary exchange
9. Determinants of capillary permeability: A review of mechanisms based on single capillary studies in the frog
10. Covalent coupling of methotrexate to dextran enhances the penetration of cytotoxicity into a tissue-like matrix
11. Equilibrium partitioning of flexible macromolecules between bulk solution and cylindrical pores
12. Effect of cell arrangement and interstitial volume fraction on the diffusivity of monoclonal antibodies in tissue
13. The radial protein concentration profile in the interstitial space of the rat ileal mesentery
14. Changes in haptoglobin and other plasma proteins of rats during exposure to pure oxygen at 760 Torr
15. Delivery of molecular and cellular medicine to solid tumors
16. The next frontier of molecular medicine - Delivery of therapeutics
17. Micropharmacology of monoclonal antibodies in solid tumors: Direct experimental evidence for a binding site barrier
18. Percolation and conduction
19. Available volume fraction of macromolecules in a fibrosarcoma: Implications for drug delivery
20. Characterization of pore size distribution of packing materials used in perfusion chromatography using a network model
21. Macromolecular basis of globular protein exclusion and of swelling pressure in loose connective tissue (umbilical cord)
22. Network modeling of the intraparticle convection and diffusion of molecules in porous particles packed in a chromatographic column
23. Capillary permeability and how it may change
24. Shared and distinct structural features of interstitial proteoglycans from different bovine tissues revealed by electron microscopy
25. Determination of glomerular size selectivity in the normal rat with Ficoll
26. Random-coil model for glomerular sieving of dextran
27. Random number generators: Good ones are hard to find
28. Estimation of effective transport coefficients in porous solids based on percolation concepts
29. Transport rates of proteins in porous materials with known microgeometry
30. Numerical simulations of angiogenesis in the cornea
31. Partitioning and diffusion of proteins and linear polymers in polyacrylamide gels
32. A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses
33. Vascular permeability in a human tumor xenograft: Molecular size dependence and cutoff size