Reductive aldol reaction of α-imino esters promoted by titanium tetraiodide: Selective synthesis of α-amino-β-hydroxyesters

Chemistry Letters

Volumn , Issue 11, 2001, Pages 1196-1197

  Shimizu, Makoto ^a   Takeuchi, Yuka ^a   Sahara, Tetsuya ^a  

^a MIE UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0035541238     PISSN: 03667022     EISSN: None     Source Type: Journal    
DOI: 10.1246/cl.2001.1196     Document Type: Article

References (25)

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20. 4 and concentrated in vacuo. Purification by flush column chromatography (n-hexane:ethyl acetate = 9:4 as an eluent) gave ethyl 3-hydroxy-3-phenyl-2-(4-toluenesulfonylamino)propionate (58.1 mg, 67%) as a colorless oil.
21. 1H NMR (NOESY) after transforming it into the corresponding acetonide as in the following typical example, in which the anti-isomer showed correlation, whereas the syn-analogue did not: (equation presented)
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