Design, syntheses, and conformational study of angiogenesis inhibitors

Bulletin of the Korean Chemical Society

Volumn 22, Issue 9, 2001, Pages 984-988

  Park, Kyoungsoo ^a   Baek, Dongha ^a   Lim, Dongyeol ^b   Park, Sang Don ^b   Kim, Min Young ^c   Park, Yong Sun ^a   Kim, Yangmee ^a  

^a Konkuk University   (South Korea)

^b Sejong University   (South Korea)

^c AngioLab Inc   (South Korea)

Author keywords

Angiogenesis inhibitor; CAM assay; NMR spectroscopy; Peptide; Peptidomimetics

Indexed keywords

ANGIOGENESIS INHIBITOR; LYSYLLEUCYLTRYTOPHYLASPARTYLPHENYLALANINE; LYSYLLEUCYLTYROSYLASPARTYLTYROSINE; PEPTIDE DERIVATIVE; PHENYLALANINE; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHICK EMBRYO; CHORIOALLANTOIS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; HYDROGEN BOND; HYDROPHOBICITY; KRINGLE DOMAIN; MOLECULAR INTERACTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN PHOSPHORYLATION; REACTION ANALYSIS; STRUCTURE ANALYSIS;

EID: 0035540408     PISSN: 02532964     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Folkman, J. Nat. Med. 1995, 1, 27.
2. Folkman, J. Harvey Lect. Ser. 1998, 92, 65.
3. Gasparini, G. Drugs 1999, 58(1), 17.
4. Gibaldi, M. J. Clin. Pharmacol. 1998, 38(10), 898.
5. Sim, B. K.; O'Reilly, M. S.; Liang, H.; Fortier, A. H.; He, W.; Madsen, J. W.; Lapcevich, R.; Nacy, C. A. Cancer Res. 1997, 57(7), 1329.
6. Bergers, G.; Javaherian, K.; Lo, K.; Folkman, J.; Hanahan, D. Science 1999, 284, 808.
7. O'Reilly, M. S.; Holmgren, L.; Shing, Y.; Chen, C.; Rosenthal, R. A.; Cao, Y.; Moses, M.; Lane, W. S.; Sage, E. H.; Folkman, J. Cold Spring Harb. Symp. Quant. Biol. 1994, 59, 471.
8. Cao, Y.; Chen, A.; An, S. S.; Ji, R. W.; Davidson, D.; Llinas, M. J. Biol. Chem. 1997, 272, 22924.
9. Lu, H.; Dhanabal, M.; Volk, R.; Waterman, M. J.; Ramchandran, R.; Knebelmann, B.; Segal, M.; Sukhatme, V. P. Biochem. Biophys. Res. Commun. 1999, 258, 668.
10. Ji, W. R.; Barrientos, L. G.; Llinas, M.; Gray, H.; Villarreal, X.; DeFord, M. E.; Castellino, F. J.; Kramer, R. A.; Trail, P. A. Biochem. Biophys. Res. Commun. 1998, 247(2), 414.
11. Chang, Y.; Mochalkin, I.; McCance, S. G.; Cheng, B.; Tulinsky, A.; Castellim, F. J. Biochemistry 1998, 37(10), 3258.
12. Lee, H.; Kim, H. K.; Lee, J. H.; You, W. K.; Chung, S. I.; Chang, S. I.; Park, M. H.; Hong, Y. K.; Joe, Y. A. Arch. Biochem. Biophys. 2000, 375(2), 359.
13. Davidson, D. J. et al. International Patent WO 97/41824.
14. Suh, H. S.; Jung, E.-J.; Kim, T.-H.; Lee, H.-Y.; Park, Y.-H.; Kim, K.-W. Cancer Letters 1997, 113, 117.
15. Strawn, L. M.; McMahon, G.; App, H.; Schreck, R.; Kuchler, W. R.; Longhi, M. P.; Hui, T. H.; Tang, C.; Levitzki, A.; Gazit, A.; Chen, I.; Keri, G.; Orfi, L.; Risau, W.; Flamme, I.; Ullrich, A.; Hirth, K. P.; Shawver, L. K. Cancer Res. 1996, 56, 3540.
16. Derome, A.; Willamson, M. J. Magn. Reson. 1990, 88, 177.
17. Bax, A.; Davis, D. G. J. Magn. Reson. 1985, 65, 355.
18. Macura, S.; Ernst, R. R. Mol. Phys. 1980, 41, 95.
19. Bax, A.; Davis, D. G. J. Magn. Reson. 1985, 63, 207.
20. Bodenhausen, G.; Ruben, D. J. J. Chem. Phys. Lett. 1980, 69, 185.
21. Clore, G. M.; Gronenborn, A. M. CRC Crit. Rev. Biochem. Mol. Biol. 1989, 24, 479.
22. Clore, G. M.; Gronenborn, A. M. Protein Sci. 1994, 3, 372.
23. Brünger, A. T. X-PLOR Manual, Version 3.1; Yale University: New Haven, CT, 1993.
24. Wüthrich, K.; Billeter, M.; Braun, W. J. Mol. Biol. 1983, 169, 949.
25. Clore, G. M.; Gronenborn, A. M.; Nilges, M.; Ryan, C. A. Biochemistry 1987, 26, 8012.
26. Nilges, M.; Clore, G. M.; Gronenborn, A. M. FEBS Lett. 1988, 229, 317.
27. Kuszewski, J.; Nilges, M.; Brünger, A. T. J. Biomol. NMR 1992, 2, 33.
28. Wüthrich, K. NMR of Protein and Nucleic Acid; Wiley-Interscience: New York, 1986.
29. Knoche, L. M. J. Am. Chem. Soc. 1984, 106, 3863.
30. Gellman, S. H.; Adams, B. R.; Dado, G. P. J. Am. Chem. Soc. 1990, 112, 460.