Computational issues in mapping variation affecting susceptibility to complex disorders: The chicken and the egg

Theoretical Population Biology

Volumn 60, Issue 3, 2001, Pages 221-225

  Cox, Nancy J ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b THE UNIVERSITY OF CHICAGO   (United States)

Author keywords

Algorithms; Complex disorders; Linkage; Mapping

Indexed keywords

DISEASE; GENETICS;

GALLUS GALLUS;

ALGORITHM; ARTICLE; CHROMOSOME MAP; GENETIC LINKAGE; GENETIC PREDISPOSITION; GENETICS; HUMAN; METHODOLOGY;

ALGORITHMS; CHROMOSOME MAPPING; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINKAGE (GENETICS); RESEARCH DESIGN;

EID: 0035528927     PISSN: 00405809     EISSN: None     Source Type: Journal    
DOI: 10.1006/tpbi.2001.1535     Document Type: Article

References (21)

1. Multilocus linkage tests based on affected relative pairs
2. Faster sequential genetic linkage computations
3. Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans
4. A general model for the genetic analysis of pedigree data
5. Allegro, a new computer program for multipoint linkage analysis
6. Markov chain Monte Carlo segregation and linkage analysis for oligogenic models
7. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
8. A faster and more general hidden Markov model algorithm for multipoint likelihood calculations
9. Allele-sharing models: LOD scores and accurate linkage tests
10. Parametric and nonparametric linkage analysis: A unified multipoint approach
11. Faster multipoint linkage analysis using fourier transforms
12. Construction of multilocus genetic linkage maps in humans
13. Efficient multi-point linkage analysis through reduction of inheritance space
14. Assessment of linkage disequilibrium by the decay of haplotype sharing, with application to fine-scale genetic mapping
15. The VITESSE algorithm for rapid exact multilocus linkage analysis via genotype set-recoding and fuzzy inheritance
16. Linkage strategies for genetically complex traits. I. Multilocus models
17. Linkage strategies for genetically complex traits. II. The power of affected relative pairs
18. Descent graphs in pedigree analysis: Applications to haplotyping, location scores and marker-sharing statistics
19. Molecular dissection of a major gene effect on a quantitative trait: The level of alcohol dehydrogenase expression in Drosophila melanogaster
20. Problems of replicating linkage claims in psychiatry
21. The affected-pedigree-member method of linkage analysis