Losartan may modulate erythropoietin production

JRAAS - Journal of the Renin-Angiotensin-Aldosterone System

Volumn 2, Issue 4, 2001, Pages 255-260

  Donnelly, Sandra M ^a   Miller, Judith A ^b  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

Angiotensin II; Erythropoietin; Filtration fraction; Losartan; Renin angiotensin system

Indexed keywords

ANGIOTENSIN II; ANTIHYPERTENSIVE AGENT; ERYTHROPOIETIN; LOSARTAN; SODIUM; VASOCONSTRICTOR AGENT;

ADULT; ARTICLE; BIOSYNTHESIS; BLOOD PRESSURE; CLINICAL TRIAL; DRUG EFFECT; ELECTROLYTE BALANCE; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; MALE; METABOLISM; PHYSIOLOGY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

ADULT; ANGIOTENSIN II; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; ERYTHROPOIETIN; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; LOSARTAN; MALE; RENIN-ANGIOTENSIN SYSTEM; SODIUM; VASOCONSTRICTOR AGENTS; WATER-ELECTROLYTE BALANCE;

EID: 0035528584     PISSN: 14703203     EISSN: None     Source Type: Journal    
DOI: 10.3317/jraas.2001.040     Document Type: Article

References (32)

1. Gurney CW, Jacobson LO, Goldwasser E. The physiologic and clinical significance of erythropoietin. Ann Intern Med 1958;49:363-70.
2. Bauer C, Kurtz A. Oxygen sensing in the kidney and its relation to erythropoietin production. Ann Rev Physiol 1989;51:845-56.
3. Donnelly S. Why is erythropoietin made in the kidney? The kidney functions as a 'critmeter'. Am J Kidney Dis 2001:38:415-25.
4. Cole J, Ertoy D, Lin H et al. Lack of angiotensin H-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient mice. J Clin Invest 2000;106(11):1391-8.
5. Anagnostou A, Baranowski R, Pillay VKG, Kurtzman N, Vercellotti G, Fried W. Effect of renin on extrarenal erythropoietin production. J Lab Clin Med 1976;88(5):707-15.
6. Freudenthaler SM, Schreeb KH, Korner T, Gleiter CH. Angiotensin II increases erythropoietin production in healthy volunteers. Eur J Clin Invest 1999;29:816-23.
7. Giffing GT, Melby JC. Enalapril (MK-421) and the white cell count and hematocrit. Lancet 1982;1:1361.
8. Conlon PJ, Farrell J, Donohoe J, Carmody M, Walshe JJ. The beneficial effect of enalapril on erythrocytosis after renal transplantation. Transplantation 1993;56:217-9.
9. Gaston RS, Julian BA, Diethelm AG, Curtis JJ. Effects of enalapril on erythrocytosis after renal transplantation. Ann Intern Med 1991;115:954-5.
10. Donnelly S, Shah DR. Erythropoietin deficiency in hyporeninemia. Am J Kidney Dis 1999;33:947-53.
11. Vlahakos DV, Balodimos C, Papachristopoulos V, Vassilakos P, Hinari E, Vlachojannis JG. Renin-angiotensin system stimulates erythropoietin secretion in chronic hemodialysis patients. Clin Nephrol 1995;43(1):53-9.
12. Piroso E, Erslev AJ, Flaharty KK, Caro J. Erythropoietin life span in rats with hypoplastic and hyperplastic bone marrows. Am J Hematol 1991;36:105-10.
13. Shuster SJ, Wilson JH, Erslev AJ, Caro J. Physiologic regulation and tissue localization of renal erythropoietin messenger RNA. Blood 1987;70:316-8.
14. Walser M, Davidson DG, Orloff J. The renal clearance of alkali-stable inulin. J Clin Invest 1955;34:1520-3.
15. Brun C. A rapid method for the determination of paraaminohippuric acid in kidney function tests. J Lab Clin Med 1951;37:955-8.
16. Roberts D, Schuh D, Smith DJ. Application of a modified INCSTAR Epo-Trac 125/RIA for measurement of serum erythropoietin concentration in elite athletes. Clin Biochem 1995;28:573-80.
17. Fried W, Barone-Varelas J, Barone T, Anagnostou A. Effect of angiotensin infusion on extrarenal erythropoietin production. J Lab Clin Med 1982;99:520-5.
18. Nowicki M, Kokot F, Wiecek A. Influence of the renin-angiotensin system stimulation on erythropoietin production in patients with various forms of arterial hypertension. Nephron 1993;65:527-32.
19. Conlon PJ, Albers F, Butterfly D, Schwab SJ. ACE inhibitors do not affect erythropoietin efficacy in haemodialysis patients. Nephrol Dial Transplant 1994;9:1358.
20. Kamper AL, Nielsen J. Effect of enalapril on hemoglobin and serum erythropoietin in patients with chronic nephropathy. Scand J Clin Invest 1990;50:611-8.
21. Hirakata H, Onoyama K, Hori K, Fujishima M. Participation of the renin-angiotensin system in the captopril-induced worsening of anemia in chronic hemodialysis patients. Clin Nephr 1986;26:27-32.
22. Hirakata H, Onoyama K, Iseki K, Kumagai H, Fugimi S, Omae T. Worsening of anemia induced by long-term use of captopril in hemodialysis patients. Am J Nephrol 1984;4:355-60.
23. Walter J. Does captopril decrease the effect of human recombinant erythropoietin in hemodialysis patients? Nephrol Dial Transplant 1993;8:1428.
24. Cruz DN, Perazella MA, Abu-Alfa AK, Mahnensmith RL. Angiotensin-converting enzyme inhibitor therapy in chronic hemodialysis patients: any evidence of erythropoietin resistance? Am J Kidney Dis 1996;28:535-10.
25. Sanchez JA. ACE inhibitors do not decrease r-HuEPO response in patients with end-stage renal failure. Nephrol Dial Transplant 1995;10:1476-7.
26. Klahr S, Hammerman M. Renal metabolism. In: Seldin DW, Giebisch G (eds.). The Kidney: physiology and pathophysiology. New York: Raven Press 1985;699-718.
27. Cohen JJ, Kamm DE. Renal metabolism: relation to renal function. In: Brenner BM, Rector FC (eds.). The Kidney Saunders, 1981;144-248.
28. Cohen JJ. Relationship between energy requirements for Na+ reabsorption and other renal functions. Kidney Int 1986;29:32-40.
29. Kramer K, Keetjen P. Oxygen consumption and sodium reabsorption in the mammalian kidney. In: Dickens F, Neil E (eds.). Oxygen in the Animal Organism; Proceedings. Oxford: Pergamon, 1963;411-31.
30. Eckardt KU, Kurtz A, Bauer C. Regulation of erythropoietin production is related to proximal tubular function. Am J Physiol 1989;256:F942-F947.
31. Brezis M, Aguron Y, Epstein FH. Determinants of intrarenal oxygenation 1 Effects of diurectics. Am J Physiol 1994; 267:F1059-F1062.
32. Roberts D, Smith DJ, Donnelly S, Simard S. Plasma-volume contraction and exercise-induced hypoxaemia modulate erythropoietin production in healthy humans. Clin Sci 2000; 98:39-45.