Immunohistochemical findings of nitric oxide synthase expression in urothelial transitional cell carcinoma including dysplasia

Oncology Reports

Volumn 8, Issue 6, 2001, Pages 1275-1279

  Hayashi, Hideki ^a   Kuwahara, Morimasa ^a   Fujisaki, Nobuta ^a   Furihata, Mutsuo ^b   Ohtsuki, Yuji ^b   Kagawa, Susumu ^c  

^a Fujisaki Hospital   (Japan)

^b KOCHI MEDICAL SCHOOL   (Japan)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Immunohistochemistry; Nitric oxide synthase; p53; Transitional cell carcinoma

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE; NOS2A PROTEIN, HUMAN; PROTEIN P53;

AGED; ARTICLE; ENZYMOLOGY; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PRECANCER; TRANSITIONAL CELL CARCINOMA; URINARY TRACT CANCER; UROTHELIUM;

AGED; CARCINOMA, TRANSITIONAL CELL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PRECANCEROUS CONDITIONS; TUMOR SUPPRESSOR PROTEIN P53; UROLOGIC NEOPLASMS; UROTHELIUM;

EID: 0035514721     PISSN: 1021335X     EISSN: None     Source Type: Journal    
DOI: 10.3892/or.8.6.1275     Document Type: Article

References (28)

1. Schmidt HHHW and Walter U: NO at work. Cell 78: 919-925, 1994.
2. Moncada S, Palmer RMJ and Higgs EA: Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 43: 109-142, 1991.
3. Knowles R and Moncada S: Nitric oxide synthase in mammals. Biochem J 298: 249-258, 1994.
4. Yagihashi N, Kasajima H, Sugai S, Matsumoto K, Ebina Y, Morita T, Murakami T and Yagihashi S: Increased in situ expression of nitric oxide synthase in human colorectal cancer. Virchows Arch 436: 109-114, 2000.
5. Vakkala M, Kahlos K, Lakari E, Paakko P, Kinnula V and Soini Y: Inducible nitric oxide synthase expression, apoptosis, and angiogenesis in situ and invasive breast carcinomas. Clin Cancer Res 6: 2408-2416, 2000.
6. Tanaka H, Kijima H, Tokunaga T, Tajima T, Himeno S, Kenmochi T, Oshiba G, Kise Y, Nishi T, Chino O, Shimada H, Machimura T, Tanaka M, Tajima T and Makuuchi H: Frequent expression of inducible nitric oxide synthase in esophageal squamous cell carcinoma. Int J Oncol 14: 1069-1073, 1999.
7. Swana HS, Smith SD, Perrotta PL, Saito N, Wheeler MA and Weiss RM: Inducible nitric oxide synthase with transitional cell carcinoma of the bladder. J Urol 161: 630-634, 1999.
8. Klotz T, Bloch W, Jacobs G, Niggemann S, Engelmann U and Addicks K: Immunolocalization of inducible and constitutive nitric oxide synthases in human bladder cancer. Urology 54: 416-419, 1999.
9. Wolf H, Haeckel C and Roessner A: Inducible nitric oxide synthase expression in human urinary bladder cancer. Virchows Arch 437: 662-666, 2000.
10. Thomsen LL, Lawton FG, Knowles RG, Beesley JE, Riveros-Moreno V and Moncada S: Nitric oxide synthase activity in human gynecological cancer. Cancer Res 54: 1352-1354, 1994.
11. Thomsen LL, Miles DW, Happerfield L, Bobrow LG, Knowles RG and Moncada S: Nitric oxide synthase activity in human breast cancer. Br J Cancer 72: 41-44, 1995.
12. Aaltomaa SH, Lipponen PK, Viitanen J, Kankkunen JP, Ala-Opas MY and Kosma VM: The prognostic value of inducible nitric oxide synthase in local prostate cancer. BJU Int 86:234-239, 2000.
13. Jenkins DC, Charles IG, Thomsen LL, Moss DW, Holmes LS, Baylis SA, Rhodes P, Westmore K, Emson PC and Moncada S: Roles of nitric oxide in tumor growth. Proc Natl Acad Sci USA 92: 4392-4396, 1995.
14. Orucevic A, Bechberger J, Green AM, Shapiro RA, BilliarTR and Lala PK: Nitric-oxide production by murine mammary adenocarcinoma cells promotes tumor-cell invasiveness. Int J Cancer 81:889-896, 1999.
15. Ambs S, Bennett WP, Merriam WG, Ogunfusika MO, Oser SM, Harrington AM, Shields PG, Felley-Bosco E, Hussain SP and Harris CC: Relationship between p53 mutations and inducible nitric oxide synthase expression in human colorectal cancer. J Natl Cancer Inst 91: 86-88, 1999.
16. Fujimoto H, Sasaki J, Matsumoto M, Suga M, Ando Y, Iggo R, Tada M, Saya H and Ando M: Significant correlation of nitric oxide synthase activity and p53 gene mutation in stage I lung adenocarcinoma. Jpn J Cancer Res 89: 696-702, 1998.
17. Hofstädter F, Delgado R, Jakse G and Judmaier W: Urothelial dysplasia and carcinoma in situ of the bladder. Cancer 57: 356-361, 1986.
18. Lamm D: Carcinoma in situ. Urol Clin North Am 19: 499-508, 1992.
19. Smith G, Elton RA, Beynon LL, Newsam JE, Chisholm GD and Hargreare TB: Prognostic significance of biopsy results of normal-looking mucosa in cases of superficial bladder cancer. Br J Urol 55: 665-669, 1983.
20. Furihata M, Yamasaki I, Ohtsuki Y, Sonobe H, Morioka M, Yamamoto A, Terao N, Kuwahara M and Fujisaki N: p53 and human papillomavirus DNA in renal pelvic and ureteral carcinoma including dysplastic lesions. Int J Cancer 64: 298-303, 1995.
21. Furihata M, Sonobe H, Ohtsuki Y, Yamashita M, Morioka M, Yamamoto A, Terao N, Kuwahara M and Fujisaki N: Detection of p53 and bcl-2 protein in carcinoma of the renal pelvis and ureter including dysplasia. J Pathol 178: 133-139, 1996.
22. Japanese Urological Association and the Society of Pathology: In: General Rule for Clinical and Pathological Studies on Renal Pelvic and Ureteral Cancer. 1st edition. Kanehara, Tokyo, 1990.
23. Japanese Urological Association and the Society of Pathology: In: General Rule for Clinical and Pathological Studies on Bladder Cancer. 2nd edition. Kanehara, Tokyo, 1993.
24. Forrester K, Ambs S, Lupold SE, Kapust RB, Spillare EA, Weinberg WC, Fellcy-Bosco E, Wang XW, Geller DA, Tzeng E, Billiar TR and Harris CC: Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53. Proc Natl Acad Sci USA 93: 2442-2447, 1996.
25. Ambs S, Hussain SP and Harris CC: Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression. FASEB J 11: 443-448, 1997.
26. Murata J, Tada M, Iggo RD, Sawamura Y, Shinohe Y and Abe H: Nitric oxide as a carcinogen: analysis by yeast functional assay of inactivating p53 mutations induced by nitric oxide. Mutat Res 379:211-218, 1997.
27. Singer II, Kawka DW, Scott S, Weidner JR, Mumford RA, Riehl TE and Stenson WF: Expression of inducible nitric oxide synthase and nitrotyrosine in colonie epithelium in inflammatory bowel disease. Gastroenterology 111: 871-885, 1996.
28. Wilson KT, Fu S, Ramanujam KS and Meltzer SJ: Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas. Cancer Res 58: 2929-2934, 1998.