Mechanical stretch in anterior cruciate ligament derived cells regulates type I collagen and decorin expression through extracellular signal-regulated kinase 1/2 pathway

Materials Science and Engineering C

Volumn 17, Issue 1-2, 2001, Pages 91-94

  Miyaki, Shigeru ^a,b   Ushida, Takashi ^b   Nemoto, Ken ^d   Shimojo, Hitoshi ^a   Itabashi, Akira ^d   Ochiai, Naoyuki ^a   Miyanaga, Yutaka ^a   Tateishi, Tetsuya ^b,c  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Anterior cruciate ligament; Collagen; Extracellular signal regulated kinase 1 2

Indexed keywords

CELLS; COLLAGEN; ENZYMES; GENES; MATERIALS SCIENCE;

GENE EXPRESSIONS;

LIGAMENTS;

MEDICAL APPLICATION;

EID: 0035504935     PISSN: 09284931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-4931(01)00314-9     Document Type: Article

References (13)

1. Collagen fibril diameters in the healing adult rabbit medial collateral ligament
2. Exercise effects on the strength of the rat anterior cruciate ligament
3. Effects of surgical treatment and immobilization on the healing of the medial collateral ligament: A long-term multidisciplinary study
4. Tensile load and the metabolism of anterior cruciate ligament cells
5. Time-dependent increases in type-III collagen gene expression in medical collateral ligament fibroblasts under cyclic strains
6. ERK and p38 MAP kinase pathways are mediators of intestinal epithelial wound-induced signal transduction
7. Matrix proteoglycans from molecular design to cellular function
8. Comparison of mRNA levels for matrix molecules in normal and disrupted human anterior cruciate ligaments using reverse transcription-polymerase chain reaction
9. Protein kinase signalling pathways involved in the up-regulation of the rat alphal(I) collagen gene by transforming growth factor beta 1 and bone morphogenetic protein 2 in osteoblastic cells
10. Hypergravity stimulates collagen synthesis in human osteoblast-like cells: Evidence for the involvement of p44/42 MAP-kinases (ERK 1/2)
11. Activation of extracellular signal-regulated kinase 1/2 inhibits type I collagen expression by human skin fibroblasts
12. Activation of extracellular signal-regurated protein kinasel, 2 results in down-regulation of decorin expression in fibroblast
13. Decorin antisense gene therapy improves functional healing of early rabbit ligament scar with enhanced collagen fibrillogenesis in vivo