The cytostatic- and differentiation-inducing effects of cyclopentenyl cytosine on neuroblastoma cell lines

Biochemical Pharmacology

Volumn 62, Issue 8, 2001, Pages 1099-1105

  Bierau, Jörgen ^a   van Gennip, Albert H ^a   Helleman, Jozien ^a   van Kuilenburg, André B P ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Chemotherapy; CTP synthetase; Cyclopentenyl cytosine; Differentiation; MYCN amplification; Neuroblastoma

Indexed keywords

1 (4,5 DIHYDROXY 3 HYDROXYMETHYL 2 CYCLOPENTEN 1 YL)CYTOSINE;

ARTICLE; CELL ACTIVITY; CELL CYCLE; CELL DIFFERENTIATION; CELL POPULATION; CELL PROLIFERATION; CELL TYPE; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSTASIS; GROWTH DISORDER; HUMAN; HUMAN CELL; INCUBATION TIME; NERVE CELL; NEUROBLASTOMA CELL; PRIORITY JOURNAL; SCHWANN CELL;

ANTINEOPLASTIC AGENTS; CARBON-NITROGEN LIGASES; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; CYTIDINE; CYTIDINE TRIPHOSPHATE; HUMANS; NEUROBLASTOMA; TUMOR CELLS, CULTURED;

EID: 0035501250     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00756-0     Document Type: Article

References (40)

1. Molecular biology of neuroblastoma
2. Clinical relevance of tumor cell ploidy and N-myc gene amplification in childhood neuroblastoma: A Pediatric Oncology Group study
3. Neuroblastoma. Effect of genetic factors on prognosis and treatment
4. MYCN oncogene amplification in neuroblastoma is associated with worse prognosis, except in stage 4s: The Italian experience with 295 children
5. A comparison of four staging systems for localized and regional neuroblastoma: A report from the Childrens Cancer Study Group
6. Increased activity of cytidine triphosphate synthetase in pediatric acute lymphoblastic leukemia
7. Imbalance in the ribonucleotide pools of lymphoid cells from acute lymphoblastic leukemia patients
8. Evidence for transformation-related increase in CTP synthetase activity in situ in human lymphoblastic leukemia
9. Comparative activities of several nucleoside analogs against influenza A, B, and C viruses in vitro
10. Cellular pharmacology of cyclopentenyl cytosine in Molt-4 lymphoblasts
11. Antiproliferative effects of cyclopentenyl cytosine (NSC 375575) in human glioblastoma cells
12. Broad-spectrum antiviral and cytocidal activity of cyclopentenylcytosine, a carbocyclic nucleoside targeted at CTP synthetase
13. Cyclopentenyl cytosine inhibits cytidine triphosphate synthetase in paediatric acute non-lymphocytic leukaemia: A promising target for chemotherapy
14. Cyclopentenylcytosine triphosphate. Formation and inhibition of CTP synthetase
15. Cyclopentenyl cytidine analogue. An inhibitor of cytidine triphosphate synthesis in human colon carcinoma cells
16. Cyclopentenyluridine and cyclopentenylcytidine analogues as inhibitors of uridine-cytidine kinase
17. Modulation of the cytotoxic effect of cyclopentenylcytosine by its primary metabolite, cyclopentenyluridine
18. In vitro characterization of the myelotoxicity of cyclopentenyl cytosine
19. Metabolism and RNA incorporation of cyclopentenyl cytosine in human colorectal cancer cells
20. Cyclopentenyl cytosine and neuroblastoma SK-N-BE(2)-C cell line cells
21. The effect of cyclopentenyl cytosine on human SK-N-BE(2)-C neuroblastoma cells
22. Genomic organization and chromosomal localization of the human CTP synthetase gene (CTPS)
23. Measurement of protein using bicinchoninic acid
24. Determination of CTP synthetase activity in crude cell homogenates by a fast and sensitive non-radiochemical assay using anion-exchange high-performance liquid chromatography
25. Multidrug resistance in human neuroblastoma cells
26. The molecular role of Myc in growth and transformation: Recent discoveries lead to new insights
27. c-Myc target genes involved in cell growth, apoptosis, and metabolism
28. An E-box-mediated increase in cad transcription at the G1/S-phase boundary is suppressed by inhibitory c-Myc mutants
29. Ribonucleotide reductases
30. Enhancement of the antileukemic activity of 5-aza-2′-deoxycytidine by cyclopentenyl cytosine in HL-60 leukemic cells
31. Enhancement of the toxicity and DNA incorporation of arabinosyl-5-azacytosine and 1-beta-D-arabinofuranosylcytosine by cyclopentenyl cytosine
32. A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage
33. The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic localization
34. Wild-type p53 can induce p21 and apoptosis in neuroblastoma cells but the DNA damage-induced G1 checkpoint function is attenuated
35. Absence of p53 gene mutations in primary neuroblastomas
36. Imbalance between the pyrimidine ribonucleotide pools in rat rhabdomyosarcoma R1 cells
37. Pyrimidine nucleotide synthesis is more extensive in poorly differentiated than in well-differentiated human gastric carcinoma
38. Induction of differentiation in the human promyelocytic leukemia cell line HL-60 by the cyclopentenyl analogue of cytidine
39. Role of antimetabolites of purine and pyrimidine nucleotide metabolism in tumor cell differentiation
40. Phase I clinical trial of continuous infusion cyclopentenyl cytosine