Transmembrane domain-mediated colocalization of HLA-DM and HLA-DR is required for optimal HLA-DM catalytic activity

Journal of Immunology

Volumn 167, Issue 9, 2001, Pages 5167-5174

  Weber, D A ^a   Dao, C T ^a   Jun, J ^a   Wigal, J L ^a   Jensen, P E ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; HLA DM ANTIGEN; HLA DR ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ARTICLE; CATALYSIS; DISSOCIATION; HLA SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

EID: 0035500914     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.9.5167     Document Type: Article

References (50)

1. HLA-DM and the MHC class II antigen presentation pathway
2. The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3
3. HLA-DM induces CLIP dissociation from MHC class II αβ dimers and facilitates peptide loading
4. Mediation by HLA-DM of dissociation of peptides from HLA-DR
5. DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide
6. The structure of HLA-DM, the peptide exchange catalyst that loads antigen onto class II MHC molecules during antigen presentation
7. Crystal structure of mouse H2-M
8. Association between HLA-DM and HLA-DR in vivo
9. HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules
10. Determination of the HLA-DM interaction site on HLA-DR molecules
11. A mutant human histocompatibility leukocyte antigen DR molecule associated with invariant chain peptides
12. Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM
13. Editing of the HLA-DR-peptide repertoire by HLA-DM
14. Human histocompatibility leukocyte antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifs
15. Negative regulation by HLA-DO of MHC class II-restricted antigen processing
16. HLA-DO is a negative modulator of HLA-DM mediated MHC class II peptide loading
17. Altered antigen presentation in mice lacking H2-O
18. Modulation of the major histocompatibility complex class II-associated peptide repertoire by human histocompatibility leukocyte antigen (HLA)-DO
19. A role for HLA-DO as a cochaperone of HLA-DM in peptide loading of MHC class II molecules
20. Altered major histocompatibility complex class II peptide loading in H2-O-deficient mice
21. Secondary structure composition and pH-dependent conformational changes of soluble recombinant HLA-DM
22. The human class II MHC protein HLA-DR1 assembles as empty αβ heterodimers in the absence of antigenic peptide
23. Two populations of la-like molecules on a human cell line
24. Engineering hybrid genes without the use of restriction enzymes: Gene splicing by overlap extension
25. Enhanced binding of peptide antigen to purified class II major histocompatibility glycoproteins at acidic pH
26. Use of eukaryotic expression technology in the functional analysis of cloned genes
27. A europium fluoroimmunoassay for measuring binding of antigen to class II MHC glycoproteins
28. Establishment and characterization of BALB/c lymphoma lines with B cell properties
29. Antigen inducible H-2-restricted, interleukin 2-producing T cell hybridomas: Lack of independent antigen and H-2 recognition
30. b haplotype reveal genetic control of isotype expression
31. + normal B cells
32. Solubilization and functional reconstitution of biomembrane components
33. Protein transfer of the costimulatory molecule, B7-B2 (CD86), into tumor membrane liposomes as a novel cell-free vaccine
34. In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides
35. The antigen-processing mutant T2 suggests a role for MHC-linked genes in class H antigen presentation
36. The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species dependent
37. Effect of HLA-DM transfection on hen egg lysozyme presentation by T2.Ak cells
38. d class]] MHC molecules expressed in normal and HLA-DM-defective human B cell lines
39. Membrane interactions influence the peptide binding behavior of DR1
40. The transmembrane sequence of human histocompatibility leukocyte antigen (HLA)-C as a determinant in inhibition of a subset of natural killer cells
41. Protein: Protein interactions in the lipid bilayer
42. Role of transmembrane domain interactions in the assembly of class II MHC molecules
43. Major histocompatibility complex class II molecules induce the formation of endocytic MIIC-like structures
44. b mice
45. Interaction between proteins localized in membranes
46. HLA-DM is present in one-fifth the amount of HLA-DR in the class II peptide-loading compartment where it associates with leupeptin-induced peptide (LIP)-HLA-DR complexes
47. The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules
48. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes
49. Regulation of MHC class II antigen presentation by sorting of recycling HLA-DM/DO and class II within the multivesicular body
50. A lipid associated with the antiphospholipid syndrome regulates endosome structure and function