Cytotoxic effects against HeLa cells of polysaccharides from seaweeds

Journal of Submicroscopic Cytology and Pathology

Volumn 33, Issue 4, 2001, Pages 477-484

  Stevan, F R ^a   Oliveira, M B M ^a   Bucchi, D F ^a   Noseda, M D ^a   Iacomini, M ^a   Duarte, M E R ^a  

^a FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

Author keywords

Cytotoxic; HeLa cells; Polysaccharide; Seaweed

Indexed keywords

ALGINIC ACID; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; FUCOIDIN; GALACTAN; GLUCURONIC ACID; HEXURONIC ACID; POLYSACCHARIDE; PORPHYRAN; SEPHAROSE;

ANIMAL; ARTICLE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; HELA CELL; HUMAN; ISOLATION AND PURIFICATION; LAMINARIA; SEAWEED; STRUCTURE ACTIVITY RELATION;

ALGINATES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL SURVIVAL; GALACTANS; GLUCURONIC ACID; HELA CELLS; HEXURONIC ACIDS; HUMANS; LAMINARIA; POLYSACCHARIDES; SEAWEED; SEPHAROSE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035495468     PISSN: 11229497     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. ANNO K., TERAHATA H., HAYASHI Y. and SENO N., 1966. Isolation and purification of fucoidin from brown seaweed Pelvetia wrightii. Agric. Biol. Chem., 30 (5), 495-499.
2. BABA M., SNOECK R., PAUWELS R. and DE CLERCQ E., 1988. Sulfated polysaccharides are potent and selective inhibitors of various enveloped viruses, including herpes simplex virus, cytomegalovirus, vesicular stomatitis virus and human immunodeficiency virus. Antimicrob. Agents Chemother., 32, 1742-1745.
3. BASTOS M.T., OLIVEIRA M.B.M., CAMPELLO A.P. and KLÜPPEL M.L.W., 1990. Methotrexate: studies on cellular metabolism. IV. Effect on the mitochondrial oxidation of cytosolic-reducing equivalents in HeLa cells. Cell. Biochem. Funct., 8, 199-203.
4. BLUMENKRANTZ N. and ASBOE-HANSEN G., 1973. New method for quantitative determination of uronic acids. Anal. Biochem., 54, 484-489.
5. COOMBE D.R., PARISH C.R., RAMSHAW I.A. and SNOWDEN J.M., 1987. Analysis of the inhibition of tumor metastasis by sulphated polysaccharides. Int. J. Cancer, 32, 82-88.
6. DOGSON K.S. and PRICE R.G., 1962. A note on the determination of the ester sulphate content of sulphated polysaccharides. Biochem. J., 84, 106-110.
7. DUARTE M.E.R., GORIN P.A.J. and DUARTE J.H., 1991. Homogeneous guluronic and mannuronic acid blocks in the alginate of the brown seaweed Laminaria brasiliensis. Phytochemistry, 30, 1707-1708.
8. DUARTE M.E.R., NOSEDA D.G., NOSEDA M.D., TULIO S., PUJOL C.A. and DAMONTE E., 2001. Inhibitory effect of sulfated galactans from the marine alga Bostrychia montagnei on Herpes simplex virus replication in vitro. Phytomedicine, 8, 53-58
9. DUBOIS M., GILLES K.A., HAMILTON J.K., REBERS P.A. and SMITH F., 1956. Colorimetric method for determination of sugars and related substances. Anal. Chem., 28, 350-356.
10. ELLOUALI M., BOISSON-VIDAL C., DURAND P. and JOZEFONVICZ J., 1993. Antitumor activity of low molecular weight fucans extracted from brown seaweed Ascophyllum nodosum. Anticancer Res., 13, 2011-2019.
11. FERNANDEZ L.E., VALIENTE O.G., MAINARDI V., BELLO J.L., VÉLEZ H. and ROSADO A., 1989. Isolation and characterization of an antitumor active agarotype polysaccharide of Gracilaria dominguensis. Carbohydr. Res., 190, 77-83.
12. FUJIHARA M., IIZIMA N., YAMAMOTO I. and NAGUMO T., 1984. Purification and chemical and physical characterization of an antitumor polysaccharide from the brown seaweed Sargassum fulvellum. Carbohydr. Res., 125, 97-106.
13. ITO H. and SUGIURA M., 1976. Antitumor polysaccharide fraction from Sargassum thunbergii. Chem. Pharm. Bull., 24, 1114-1115.
14. LOGEART D., LETOURNEUR D., JOZEFONVICZ J. and KERN P., 1996. Collagen synthesis by vascular smooth muscle cells in the presence of antiproliferative polysaccharides. J. Biomed. Mat. Res., 30, 501-508.
15. LOWRY O.L., ROSEBROUGH N.J. and FARR A.L., 1951. Protein measurement with the folin phenol reagent. J. Biol. Chem., 193, 265-275.
16. MORI H. and NISHIZAWA K., 1982. Sugar constituents of sulfated polysaccharides from the fronds of Sargassum ringoldianum. Bull. Jpn. Soc. Sci. Fish., 48, 981-986.
17. NISHINO T., NAGUMO T., KYIOHARA H. and YAMADA H., 1991. Structural characterization of a new anticoagulant fucan sulfate from the brown seaweed Eklonia kurome. Carbohydr. Res., 211, 77-90.
18. NODA H., AMANO H., ARASHIMA K. and NISIZAWA K., 1990. Antitumor activity of marine algae. Hydrobiologia, 204/205, 577-584.
19. NOSEDA M.D., TISCHER C.A., GORIN P.A.J., CEREZO A.S. and DUARTE M.E.R., 1997. NMR studies of polysaccharides from brown seaweeds. Anais do VI AUREMN, Angra dos Reis RJ, pp. 325-330.
20. NOSEDA M.D., TULIO S. and DUARTE M.E.R., 1999a. Polysaccharides from the red seaweed Bostrychia montagnei: chemical characterization. J. Appl. Phycol., 11, 35-40.
21. NOSEDA M.D., VIANA A.G., DUARTE M.E.R. and CEREZO A.S., 1999b. Alkali modification of carrageenans - Part IV - Porphyrans as model compounds. Carbohydr. Polym., 11, 301-305.
22. PARISH C.R. and SNOWDEN J. MCK., 1988. Sulphated polysaccharides having metastatic and/or anti-inflammatory activity. PCT Application No WO 88/05301.
23. PARISH C.R., COOMBE D.R., JAKOBSEN K.B., BENNETT F.A. and UNDERWOOD P.A., 1987. Evidence that sulphated polysaccharides inhibit tumor metastasis by blocking tumor-cell-derived heparanases. Int. J. Cancer, 40, 511-518.
24. PHILLIPS H.J., 1973. Dye exclusion tests for cell viability. In: 'Tissue culture, Methods and Applications'. Kruse M.K. ed., Acad. Press, New York, pp. 406-408.
25. RIOU D., COLLECJOUAULT S., DUSEL D.P., BOSH S., SIACOUSHIAN S., LEBERT V., TOMASONI C., SINQUIN C., DURAND P. and ROUSSAKIS C., 1996. Antitumor and antiproliferative effects of a fucan extracted from Ascophyllum nodosum against a non-small-cell bronchopulmonary carcinoma line. Anticancer Res., 16, 1213-1218.
26. ROCHA H.A.O., FRANCO C.RC., TRINIDADE E.S., CARVALHO L.C.M., VEIGA S.S., LEITE E.L., DIETRICH C.P. and NADER H.B., 2001. A fucan from the brown seaweed spatoglossum schröederi inhibits Chinese hamster ovary cell adhesion to several extracellular matrix proteins. Br. J. Med. Biol. Res., 34, 621-626
27. STEVENSON T.T. and FURNEAUX R.H., 1991. Chemical methods for the analysis of sulphated galactans from red algae. Carbohydr. Res., 210, 277-298.
28. YAMAMOTO I., TAKAHASHI M., SUZUKI T., SEIKO H. and MORI H., 1984. Antitumor effect of seaweeds. IV. Enhancement of antitumor activity by sulfation of a crude fucoidan fraction from Sargassum kjellmanianum. Japan J. Exp. Med., 54, 143-151.