Myostatin in muscle growth and repair

Exercise and Sport Sciences Reviews

Volumn 29, Issue 4, 2001, Pages 155-158

  Sharma, Mridula ^a   Langley, Brett ^a   Bass, John ^a   Kambadur, Ravi ^a  

^a RUAKURA RESEARCH CENTRE   (New Zealand)

Author keywords

Gene expression; Hyperplasia; Hypertrophy; Myoblast; Myogenesis; Myostatin; Skeletal muscle

Indexed keywords

MYOSTATIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETICS; HOMEOSTASIS; HUMAN; PHYSIOLOGY; PRENATAL DEVELOPMENT; REGENERATION; REVIEW; SKELETAL MUSCLE;

ANIMALS; GENE EXPRESSION; HOMEOSTASIS; HUMANS; MUSCLE, SKELETAL; REGENERATION; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 0035489215     PISSN: 00916331     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003677-200110000-00004     Document Type: Article

References (15)

1. Carlson, C.J., F.W. Booth, and S.E. Gordon. Skeletal muscle myostatin mRNA expression is fiber-type specific and increases during hindlimb unloading. Am. J. Physiol. 277:R601-606, 1999.
2. Ewen, M.E. Where the cell cycle and histones meet. Genes Dev. 14: 2265-2270, 2000.
3. Ferrell, R.E., V. Conte, E.G. Lawrence, S.M. Roth, J.M. Hagberg, and B.F. Hurley. Frequent sequence variation in the human myostatin (GDF8) gene as a marker for analysis of muscle-related phenotypes. Genomics. 62:203-207, 1999.
4. Gonzalez-Cadavid, N.F., W.E. Taylor, K. Yarasheski, I. Sinha-Hikim, K. Ma, S. Ezzat, R. Shen, R. Lalani, S. Asa, M. Mamita, G. Nair, S. Arver, and S. Bhasin. Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting. Proc. Natl. Acad. Sci. U S A. 95:14938-14943, 1998.
5. Grobet, L., D. Poncelet, L.J. Royo, B. Brouwers, D. Pirottin, C. Michaux, F. Menissier, M. Zanotti, S. Dunner, and M. Georges. Molecular definition of an allelic series of mutations disrupting the myostatin function and causing double-muscling in cattle. Mamm. Genome. 9:210-213, 1998.
6. Ji, S., R.L. Losinski, S.G. Cornelius, G.R. Frank, G.M. Willis, D.E. Gerrard, F.F. Depreux, and M.E. Spurlock. Myostatin expression in porcine tissues: tissue specificity and developmental and postnatal regulation. Am. J. Physiol. 275:R1265-1273, 1998.
7. Kambadur, R., M. Sharma, T.P. Smith, and J.J. Bass. Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle. Genome Res. 7:910-916, 1997.
8. Kim, H.S., L. Liang, R.G. Dean, D.B. Hausman, D.L. Hartzell, and C.A. Baile. Inhibition of preadipocyte differentiation by myostatin treatment in 3T3-L1 cultures. Biochem. Biophys. Res. Commun. 281:902-906, 2001.
9. Kirk, S., J. Oldham, R. Kambadur, M. Sharma, P. Dobbie, and J. Bass. Myostatin regulation during skeletal muscle regeneration. J. Cell Physiol. 184:356-363, 2000.
10. McPherron, A.C., A.M. Lawler, and S.J. Lee. Regulation of skeletal muscle mass in mice by a new TGF-β superfamily member. Nature. 387:83-90, 1997.
11. Roberts, S.B., and F.W. Goetz. Differential skeletal muscle expression of myostatin across teleost species, and the isolation of multiple myostatin isoforms. FEBS Lett. 491:212-216, 2001.
12. Sharma, M., R. Kambadur, K.G. Matthews, W.G. Somers, G.P. Devlin, J.V. Conaglen, P.J. Fowke, and J.J. Bass. Myostatin, a transforming growth factor-β superfamily member, is expressed in heart muscle and is upregulated in cardiomyocytes after infarct. J. Cell Physiol. 180:1-9, 1999.
13. Thomas, M., B. Langley, C. Berry, M. Sharma, S. Kirk, J. Bass, and R. Kambadur. Myostatin, a negative regulator of muscle growth, functions by inhibiting myoblast proliferation. J. Biol. Chem. 275:40235-40243, 2000.
14. Wehling, M., B. Cai, and J.G. Tidball. Modulation of myostatin expression during modified muscle use. Faseb. J. 14:103-110, 2000.
15. Zhu, X., M. Hadhazy, M. Wehling, J.G. Tidball, and E. M. McNally. Dominant negative myostatin produces hypertrophy without hyperplasia in muscle. FEBS Lett. 474:71-75, 2000.