-
1
-
-
0031037207
-
The search for antimicrobial agents effective against bacteria resistant to multiple antibiotics
-
Chopra I, Hodgson J, Metcalf B, Poste G: The search for antimicrobial agents effective against bacteria resistant to multiple antibiotics. Antimicrob Agents Chemother 1997, 41:497-503.
-
(1997)
Antimicrob Agents Chemother
, vol.41
, pp. 497-503
-
-
Chopra, I.1
Hodgson, J.2
Metcalf, B.3
Poste, G.4
-
2
-
-
0030921538
-
Emergent antibiotic resistance: Health risks and economic impact
-
Cassell GH: Emergent antibiotic resistance: health risks and economic impact. FEMS Immunol Med Microbiol 1997, 18:271-274.
-
(1997)
FEMS Immunol Med Microbiol
, vol.18
, pp. 271-274
-
-
Cassell, G.H.1
-
3
-
-
0034680096
-
Changing patterns of infectious disease
-
Cohen ML: Changing patterns of infectious disease. Nature 2000, 406:762-767. This review summarises recent demographic and epidemiological changes affecting infectious diseases, including bacterial infections.
-
(2000)
Nature
, vol.406
, pp. 762-767
-
-
Cohen, M.L.1
-
4
-
-
0035042571
-
Increasing resistance to vancomycin and other glycopeptides in Staphylococcus aureus
-
Tenover FC, Biddle JW, Lancaster MV: Increasing resistance to vancomycin and other glycopeptides in Staphylococcus aureus. Emerg Infect Dis 2001, 7:327-332.
-
(2001)
Emerg Infect Dis
, vol.7
, pp. 327-332
-
-
Tenover, F.C.1
Biddle, J.W.2
Lancaster, M.V.3
-
5
-
-
0035857967
-
Infections due to vancomycin-resistant Enterococcus faecium resistant to linezolid
-
Gonzales RD, Schreckenberger PC, Graham MB, Kelkar S, DenBesten K, Quinn JP: Infections due to vancomycin-resistant Enterococcus faecium resistant to linezolid. Lancet 2001, 357:1179. The authors report the emergence of enterococcal resistance to linezolid in the clinical setting. The emergence of resistance has been disappointingly rapid in view of the fact that linezolid represents a new antibiotic class (the oxazolidinones), only approved by the FDA in 2000.
-
(2001)
Lancet
, vol.357
, pp. 1179
-
-
Gonzales, R.D.1
Schreckenberger, P.C.2
Graham, M.B.3
Kelkar, S.4
DenBesten, K.5
Quinn, J.P.6
-
6
-
-
0030774640
-
New strategies for antibacterial drug design
-
Knowles DJC: New strategies for antibacterial drug design. Trends Microbiol 1997, 5:379-383.
-
(1997)
Trends Microbiol
, vol.5
, pp. 379-383
-
-
Knowles, D.J.C.1
-
7
-
-
0027358590
-
In vitro and in vivo antibacterial activities of the glycylcyclines, a new class of semisynthetic tetracyclines
-
Testa RT, Petersen PJ, Jacobus NL, Sum PE, Lee VJ, Tally FP: In vitro and in vivo antibacterial activities of the glycylcyclines, a new class of semisynthetic tetracyclines. Antimicrob Agents Chemother 1993, 37:2270-2277.
-
(1993)
Antimicrob Agents Chemother
, vol.37
, pp. 2270-2277
-
-
Testa, R.T.1
Petersen, P.J.2
Jacobus, N.L.3
Sum, P.E.4
Lee, V.J.5
Tally, F.P.6
-
8
-
-
0027958117
-
Glycylcyclines. 1. A new generation of potent antibacterial agents through modification of 9-aminotetracyclines
-
Sum PE, Lee VJ, Testa RT, Hlavka JJ, Ellestad GA, Bloom JD, Gluzman Y, Tally FP: Glycylcyclines. 1. A new generation of potent antibacterial agents through modification of 9-aminotetracyclines. J Med Chem 1994, 37:184-188.
-
(1994)
J Med Chem
, vol.37
, pp. 184-188
-
-
Sum, P.E.1
Lee, V.J.2
Testa, R.T.3
Hlavka, J.J.4
Ellestad, G.A.5
Bloom, J.D.6
Gluzman, Y.7
Tally, F.P.8
-
9
-
-
0028019770
-
Glycylcyclines 3.9-aminodoxycyclinecarboxamides
-
Barden TC, Buckwalter BL, Testa RT, Petersen PJ, Lee VJ: Glycylcyclines 3.9-aminodoxycyclinecarboxamides. J Med Chem 1994, 37:3205-3211.
-
(1994)
J Med Chem
, vol.37
, pp. 3205-3211
-
-
Barden, T.C.1
Buckwalter, B.L.2
Testa, R.T.3
Petersen, P.J.4
Lee, V.J.5
-
10
-
-
0034973583
-
Tetracycline antibiotics: Mode of action, applications, molecular biology and epidemiology of bacterial resistance
-
Chopra I, Roberts M: Tetracycline antibiotics: mode of action, applications, molecular biology and epidemiology of bacterial resistance. Microbiol Mol Biol Rev 2001, 65:232-260. A recent comprehensive review discussing microbiological, molecular and medical aspects of tetracyclines and the discovery and development of the glycylcyclines
-
(2001)
Microbiol Mol Biol Rev
, vol.65
, pp. 232-260
-
-
Chopra, I.1
Roberts, M.2
-
12
-
-
0031862823
-
16S rRNA mutation associated with tetracycline resistance in a Gram-positive bacterium
-
Ross JI, Eady EA, Cove JH, Cunliffe WJ: 16S rRNA mutation associated with tetracycline resistance in a Gram-positive bacterium. Antimicrob Agents Chemother 1998, 42:1702-1705.
-
(1998)
Antimicrob Agents Chemother
, vol.42
, pp. 1702-1705
-
-
Ross, J.I.1
Eady, E.A.2
Cove, J.H.3
Cunliffe, W.J.4
-
13
-
-
0028275776
-
Inhibition of protein synthesis occurring on tetracycline-resistant, TetM-protected ribosomes by a novel class of tetracyclines, the glycylcyclines
-
Rasmussen BA, Gluzman Y, Tally FP: Inhibition of protein synthesis occurring on tetracycline-resistant, TetM-protected ribosomes by a novel class of tetracyclines, the glycylcyclines. Antimicrob Agents Chemother 1994, 38:1658-1660.
-
(1994)
Antimicrob Agents Chemother
, vol.38
, pp. 1658-1660
-
-
Rasmussen, B.A.1
Gluzman, Y.2
Tally, F.P.3
-
14
-
-
0033577725
-
Synthesis and structure-activity relationship of novel glycylcycline derivatives leading to the discovery of GAR-936
-
Sum PE, Petersen P: Synthesis and structure-activity relationship of novel glycylcycline derivatives leading to the discovery of GAR-936. Bioorg Med Chem Lett 1999, 9:1459-1462.
-
(1999)
Bioorg Med Chem Lett
, vol.9
, pp. 1459-1462
-
-
Sum, P.E.1
Petersen, P.2
-
15
-
-
0032918653
-
In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936)
-
Petersen PJ, Jacobus NV, Weiss WJ, Sum PE, Testa RT: In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936). Antimicrob Agents Chemother 1999, 43:738-744.
-
(1999)
Antimicrob Agents Chemother
, vol.43
, pp. 738-744
-
-
Petersen, P.J.1
Jacobus, N.V.2
Weiss, W.J.3
Sum, P.E.4
Testa, R.T.5
-
16
-
-
0027430074
-
In vitro activity of DMG-Mino and DMG-DM Dot, two new glycylcyclines, against anaerobic bacteria
-
Nord CE, Lindmark A, Persson I: In vitro activity of DMG-Mino and DMG-DM Dot, two new glycylcyclines, against anaerobic bacteria. Eur J Clin Microbiol Infect Dis 1993, 12:784-786.
-
(1993)
Eur J Clin Microbiol Infect Dis
, vol.12
, pp. 784-786
-
-
Nord, C.E.1
Lindmark, A.2
Persson, I.3
-
17
-
-
0028203686
-
In vitro activities of two glycylcyclines against Gram-positive bacteria
-
Eliopoulos GM, Wennersten CB, Cole G, Moellering RC: In vitro activities of two glycylcyclines against Gram-positive bacteria. Antimicrob Agents Chemother 1994, 38:534-541.
-
(1994)
Antimicrob Agents Chemother
, vol.38
, pp. 534-541
-
-
Eliopoulos, G.M.1
Wennersten, C.B.2
Cole, G.3
Moellering, R.C.4
-
18
-
-
0028031419
-
N,N-dimethylglycyl-amido derivative of minocycline and 6-demethyl-6-deoxytetracycline, two new glycylcyclines highly effective against tetracycline-resistant Gram-positive cocci
-
Goldstein FW, Kitzis MD, Acar JF: N,N-dimethylglycyl-amido derivative of minocycline and 6-demethyl-6-deoxytetracycline, two new glycylcyclines highly effective against tetracycline-resistant Gram-positive cocci. Antimicrob Agents Chemother 1994, 38:2218-2220.
-
(1994)
Antimicrob Agents Chemother
, vol.38
, pp. 2218-2220
-
-
Goldstein, F.W.1
Kitzis, M.D.2
Acar, J.F.3
-
19
-
-
0027939141
-
Susceptibilities of Mycoplasma hominis, Mycoplasma pneumoniae and Ureaplasma urealyticum to new glycylcyclines in comparison with those to older tetracyclines
-
Kenny GE, Cartwright FD: Susceptibilities of Mycoplasma hominis, Mycoplasma pneumoniae and Ureaplasma urealyticum to new glycylcyclines in comparison with those to older tetracyclines. Antimicrob Agents Chemother 1994, 38:2628-2632.
-
(1994)
Antimicrob Agents Chemother
, vol.38
, pp. 2628-2632
-
-
Kenny, G.E.1
Cartwright, F.D.2
-
20
-
-
0028085951
-
In vitro activities of two new glycylcyclines, N,N-dimethylglycylamido derivatives of minocycline and 6-demethyl-6-deoxytetracycline, against 339 strains of anaerobic bacteria
-
Wexler HM, Molitoris E, Finegold SM: In vitro activities of two new glycylcyclines, N,N-dimethylglycylamido derivatives of minocycline and 6-demethyl-6-deoxytetracycline, against 339 strains of anaerobic bacteria. Antimicrob Agents Chemother 1994, 38:2513-2515
-
(1994)
Antimicrob Agents Chemother
, vol.38
, pp. 2513-2515
-
-
Wexler, H.M.1
Molitoris, E.2
Finegold, S.M.3
-
22
-
-
0029115864
-
In vitro activity of two glycylcyclines against enterococci resistant to other agents
-
Fraise AP, Brenwald N, Andrews JM, Wise R: In vitro activity of two glycylcyclines against enterococci resistant to other agents. J Antimicrob Chemother 1995, 35:877-881.
-
(1995)
J Antimicrob Chemother
, vol.35
, pp. 877-881
-
-
Fraise, A.P.1
Brenwald, N.2
Andrews, J.M.3
Wise, R.4
-
23
-
-
0029149238
-
Susceptibility of enterococci, methicillin-resistant Staphylococcus aureus and Streptococcus pneumoniae to the glycylcyclines
-
Weiss WJ, Jacobus NV, Petersen PJ, Testa RT: Susceptibility of enterococci, methicillin-resistant Staphylococcus aureus and Streptococcus pneumoniae to the glycylcyclines. J Antimicrob Chemother 1995, 36:225-230.
-
(1995)
J Antimicrob Chemother
, vol.36
, pp. 225-230
-
-
Weiss, W.J.1
Jacobus, N.V.2
Petersen, P.J.3
Testa, R.T.4
-
24
-
-
0029059619
-
Susceptibilities of Neisseria gonorrhoeae to the glycylcyclines
-
Whittington WL, Roberts MC, Hale J, Holmes KK: Susceptibilities of Neisseria gonorrhoeae to the glycylcyclines. Antimicrob Agents Chemother 1995, 39:1864-1865.
-
(1995)
Antimicrob Agents Chemother
, vol.39
, pp. 1864-1865
-
-
Whittington, W.L.1
Roberts, M.C.2
Hale, J.3
Holmes, K.K.4
-
25
-
-
0029921726
-
Activities of the glycylcyclines N,N-dimethylglycylamido-minocycline and N,N-dimethylglycylamido-6-demethyl-6-deoxytetracycline against Nocardia spp. and tetracycline-resistant isolates of rapidly growing mycobacteria
-
Brown BA, Wallace RJ, Onyi G: Activities of the glycylcyclines N,N-dimethylglycylamido-minocycline and N,N-dimethylglycylamido-6-demethyl-6-deoxytetracycline against Nocardia spp. and tetracycline-resistant isolates of rapidly growing mycobacteria. Antimicrob Agents Chemother 1996, 40:874-878.
-
(1996)
Antimicrob Agents Chemother
, vol.40
, pp. 874-878
-
-
Brown, B.A.1
Wallace, R.J.2
Onyi, G.3
-
26
-
-
0029737275
-
Activity of glycylcyclines CL 329998 and CL 331002 against minocycline-resistant and other strains of methicillin-resistant Staphylococcus aureus
-
Hamilton-Miller JMT, Shah S: Activity of glycylcyclines CL 329998 and CL 331002 against minocycline-resistant and other strains of methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother 1996, 37:1171-1175.
-
(1996)
J Antimicrob Chemother
, vol.37
, pp. 1171-1175
-
-
Hamilton-Miller, J.M.T.1
Shah, S.2
-
27
-
-
0030951636
-
Comparative in vitro activities of RP59500 (quinupristin/ dalfopristin), CL 329,998, CL 331,002, trovafloxacin, clinafloxacin, teicoplanin and vancomycin against Gram-positive bacteria
-
Shonekan D, Handwerger S, Mildvan D: Comparative in vitro activities of RP59500 (quinupristin/ dalfopristin), CL 329,998, CL 331,002, trovafloxacin, clinafloxacin, teicoplanin and vancomycin against Gram-positive bacteria. J Antimicrob Chemother 1997, 39:405-409.
-
(1997)
J Antimicrob Chemother
, vol.39
, pp. 405-409
-
-
Shonekan, D.1
Handwerger, S.2
Mildvan, D.3
-
28
-
-
0033926236
-
In vitro activities of the glycylcycline GAR-936 against Gram-positive bacteria
-
Boucher HW, Wennersten CB, Eliopoulos GM: In vitro activities of the glycylcycline GAR-936 against Gram-positive bacteria. Antimicrob Agents Chemother 2000, 44:2225-2229. This paper presents the results of in vitro susceptibility testing with GAR-936 (the candidate clinical glycylcycline) against a large collection of Gram-positive clinical isolates. The data generally demonstrate the superior activity of GAR-936 compared with earlier tetracyclines.
-
(2000)
Antimicrob Agents Chemother
, vol.44
, pp. 2225-2229
-
-
Boucher, H.W.1
Wennersten, C.B.2
Eliopoulos, G.M.3
-
29
-
-
0033954848
-
Antimicrobial activity and spectrum of the new glycylcycline, GAR-936 tested against 1,203 recent clinical bacterial isolates
-
Gales AC, Jones RN: Antimicrobial activity and spectrum of the new glycylcycline, GAR-936 tested against 1,203 recent clinical bacterial isolates. Diagn Microb Infect Dis 2000, 36:19-36. This paper presents the results of in vitro susceptibility testing with GAR-936 against a large collection of Gram-positive and Gram-negative clinical isolates. The data generally demonstrate the superior activity of GAR-936 compared with earlier tetracyclines.
-
(2000)
Diagn Microb Infect Dis
, vol.36
, pp. 19-36
-
-
Gales, A.C.1
Jones, R.N.2
-
30
-
-
0034075749
-
In vivo pharmacodynamic activities of two glycylcyclines (GAR-936 and WAY 152,288) against various Gram-positive and Gram-negative bacteria
-
van Ogtrop ML, Andes D, Stamstad TJ, Conklin B, Weiss WJ, Craig WA, Vesga O: In vivo pharmacodynamic activities of two glycylcyclines (GAR-936 and WAY 152,288) against various Gram-positive and Gram-negative bacteria. Antimicrob Agents Chemother 2000, 44:943-949. This paper reports promising pharmacodynamic data for GAR-936 in a variety of murine infection models. It also reports pharmacokinetic data in mice and predicts a possible dosing regimen for GAR-936 for therapeutic use in man.
-
(2000)
Antimicrob Agents Chemother
, vol.44
, pp. 943-949
-
-
Van Ogtrop, M.L.1
Andes, D.2
Stamstad, T.J.3
Conklin, B.4
Weiss, W.J.5
Craig, W.A.6
Vesga, O.7
-
31
-
-
0033818355
-
Preclinical pharmacology of GAR-936, a novel glycylcycline antibacterial agent
-
Projan SJ: Preclinical pharmacology of GAR-936, a novel glycylcycline antibacterial agent. Pharmacotherapy 2000, 20:219S-223S.
-
(2000)
Pharmacotherapy
, vol.20
-
-
Projan, S.J.1
-
32
-
-
0002702892
-
Pharmacokinetics (PK), safety and tolerability of GAR-936, a novel glycylcycline antibiotic, in healthy subjects
-
Washington DC: American Society for Microbiology
-
Muralidharan G, Getsy J, Mayer P, Paty I, Micalizzi M, Speth J, Wester B, Mojaverian P: Pharmacokinetics (PK), safety and tolerability of GAR-936, a novel glycylcycline antibiotic, in healthy subjects. In Abstracts of the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC): 1999 Sept 26-29; San Francisco. Washington DC: American Society for Microbiology; 1999:303.
-
(1999)
Abstracts of the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC): 1999 Sept 26-29; San Francisco
, pp. 303
-
-
Muralidharan, G.1
Getsy, J.2
Mayer, P.3
Paty, I.4
Micalizzi, M.5
Speth, J.6
Wester, B.7
Mojaverian, P.8
-
33
-
-
0034476869
-
Mutations in the interdomain loop region of the tetA(A) tetracycline resistance gene increase efflux of minocycline and glycylcyclines
-
Tuckman M, Petersen PJ, Projan SJ: Mutations in the interdomain loop region of the tetA(A) tetracycline resistance gene increase efflux of minocycline and glycylcyclines. Microbiol Drug Res 2000, 6:277-282. This paper describes the molecular basis of resistance to early members of the glycylcyclines arising in Gram-negative tet efflux pumps. It also addresses the potential for resistance to GAR-936 arising by further mutation in existing tetracycline efflux pumps.
-
(2000)
Microbiol Drug Res
, vol.6
, pp. 277-282
-
-
Tuckman, M.1
Petersen, P.J.2
Projan, S.J.3
-
34
-
-
0028205510
-
Mutations in the tetA(B) gene that cause a change in substrate specificity of the tetracycline efflux pump
-
Guay GG, Tuckman M, Rothstein DM: Mutations in the tetA(B) gene that cause a change in substrate specificity of the tetracycline efflux pump. Antimicrob Agents Chemother 1994, 38:857-860.
-
(1994)
Antimicrob Agents Chemother
, vol.38
, pp. 857-860
-
-
Guay, G.G.1
Tuckman, M.2
Rothstein, D.M.3
-
35
-
-
85031471892
-
Tetracyclines
-
Edited by O'Grady F, Lambert HP, Finch RG, Greenwood D. New York: Churchill Livingstone; 199
-
Finch RG: Tetracyclines. In Antibiotic and Chemotherapy, edn 7. Edited by O'Grady F, Lambert HP, Finch RG, Greenwood D. New York: Churchill Livingstone; 199:469-484.
-
Antibiotic and Chemotherapy, Edn 7.
, pp. 469-484
-
-
Finch, R.G.1
|