Blood-retinal barrier breakdown in experimental coronavirus retinopathy: Association with viral antigen, inflammation, and VEGF in sensitive and resistant strains

Journal of Neuroimmunology

Volumn 119, Issue 2, 2001, Pages 175-182

  Vinores, Stanley A ^a   Wang, Yun ^b   Vinores, Melissa A ^a   Derevjanik, Nancy L ^a   Shi, Albert ^a   Klein, Diane A ^a   Detrick, Barbara ^c   Hooks, John J ^b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Blood retinal barrier; Coronavirus; Retinopathy; Vascular endothelial growth factor

Indexed keywords

VASCULOTROPIN; VIRUS ANTIGEN;

ANIMAL TISSUE; ARTICLE; BLOOD RETINA BARRIER; CELL DESTRUCTION; CONTROLLED STUDY; IMMUNOREACTIVITY; INFLAMMATION; INOCULATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; RETINA CELL; RETINA DEGENERATION; RETINA DISEASE; RETINOPATHY; VIRUS INFECTION; VIRUS RESISTANCE; VIRUS STRAIN;

ANIMALS; ANTIGENS, VIRAL; BLOOD-RETINAL BARRIER; CELLS, CULTURED; CORONAVIRUS INFECTIONS; ENDOTHELIAL GROWTH FACTORS; IMMUNITY, NATURAL; IMMUNOHISTOCHEMISTRY; LEUKOCYTES; LYMPHOKINES; MALE; MICE; MICE, INBRED BALB C; MURINE HEPATITIS VIRUS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RETINA; RETINITIS; SERUM ALBUMIN; SPECIES SPECIFICITY; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0035479023     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(01)00374-5     Document Type: Article

References (49)

1. Cross-reaction of a rat-anti-mouse phagocyte-specific monoclonal antibody (anti-Mac-1) with human monocytes and natural killer cells
2. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1
3. Localization of vascular endothelial growth factor and its receptors to cells of vascular and avascular epiretinal membranes
4. Vascular permeability factor: A tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration
5. The vascular endothelial growth factor receptor Flt-1 mediates biological activities. Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis
6. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability and angiogenesis
7. Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin
8. Adenosine as an endogenous mediator of hypoxia for induction of vascular endothelial growth factor mRNA in U-937 cells
9. Vascular endothelial growth factor (VEGF) stimulates monocyte migration through endothelial monolayers via increased integrin expression
10. Retina and retinal pigment epithelial cell autoantibodies are produced during murine coronavirus retinopathy
11. Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia
12. VEGF increases retinal vascular ICAM-1 expression in vivo
13. Blood-retinal barrier (BRB) breakdown in experimental autoimmune uveoretinitis: Comparison with vascular endothelial growth factor, tumor necrosis factor α, and interleukin-1β-mediated breakdown
14. Test for trend in proportions
15. During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium
16. Hypoxic stimulation of vascular endothelial growth factor expression in vitro and in vivo
17. Hypoxia regulatory elements of the human vascular endothelial growth factor gene
18. Transgenic mice with increased expression of vascular endothelial growth factor in the retina. A new model of intraretinal and subretinal neovascularization
19. Intravitreal sustained release of VEGF causes retinal neovascularization in rabbits and breakdown of the blood-retinal barrier in rabbits and primates
20. Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization
21. Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo
22. Murine coronavirus induces an acute and long-lasting disease of the retina
23. Ocular tropisms of murine coronavirus (strain JHM) after inoculation by various routes
24. Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor
25. Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans
26. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
27. A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines
28. Characterization of vascular permeability factor/vascular endothelial growth factor receptors on mononuclear phagocytes
29. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
30. Natural killer cells prevent direct anterior-to-posterior spread of herpes simplex virus type I in the eye
31. Assessment of blood-retinal barrier integrity
32. Immunohistochemical localization of blood-retinal barrier breakdown in human diabetics
33. Ultrastructural localization of blood-retinal barrier sites in diabetic and galactosemic rats
34. Localization of blood-retinal barrier breakdown in human pathologic specimens by immunohistochemical staining for albumin
35. 1 cause breakdown of the blood-retinal barrier by opening tight junctions between vascular endothelial cells
36. Electron microscopic immunocytochemical demonstration of blood-retinal barrier breakdown in human diabetics and its association with aldose reductase in retinal vascular endothelium and retinal pigment epithelium
37. Electron microscopic immunocytochemical evidence for the mechanism of blood-retinal barrier breakdown in galactosemic rats and its association with aldose reductase expression and inhibition
38. Immunohistochemical localization of blood-retinal barrier breakdown sites associated with post-surgical macular edema
39. Blood-retinal barrier breakdown in retinitis pigmentosa: Light and electron microscopic immunolocalization
40. Blood-retinal barrier breakdown in eyes with ocular melanoma: A potential role for vascular endothelial growth factor
41. Upregulation of VEGF and TGFβ2 in experimental herpesvirus retinopathy
42. Upregulation of vascular endothelial growth factor in ischemic and non-ischemic human and experimental retinal disease
43. Increased vascular endothelial growth factor (VEGF) and transforming growth factor β (TGFβ) in experimental autoimmune uveoretinitis: Upregulation of VEGF without neovascularization
44. Electron microscopic evidence for the mechanism of blood-retinal barrier breakdown in diabetic rabbits: Comparison with magnetic resonance imaging
45. Coronavirus (JHM) replication within the retina: Analysis of cell tropism in mouse retinal cell cultures
46. Genetic predisposition to coronavirus-induced retinal disease
47. The role of apoptosis within the retina of coronavirus infected mice
48. Ocular disease induced in mice by anterior chamber inoculation of herpes simplex virus