Disturbed oligodendrocyte development and recovery from hypomyelination in a c-myc transgenic mouse mutant

Journal of Neuroscience Research

Volumn 66, Issue 1, 2001, Pages 46-58

  Orian, Jacqueline M ^a,b   Ahern, Alan J ^a,b   Ayers, Margaret M ^c   Levine, Joel M ^d   Tapp, Luke D ^a,b   Reynolds, Richard ^a,b  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b LA TROBE UNIVERSITY   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d Stony Brook University   (United States)

Author keywords

C myc; Delayed myelination; Hypomyelination; Oligodendrocyte development; Transgenic mutant

Indexed keywords

MYC PROTEIN; MYELIN; MYELIN BASIC PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LINEAGE; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION; LONGEVITY; MOUSE MUTANT; MYELINATION; NERVE CELL DIFFERENTIATION; NONHUMAN; OLIGODENDROGLIA; ONCOGENE C MYC; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

AGE FACTORS; ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELL DIVISION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, MYC; IN SITU NICK-END LABELING; MICE; MICE, TRANSGENIC; MYELIN SHEATH; OLIGODENDROGLIA; PHENOTYPE; RECOVERY OF FUNCTION; STEM CELLS;

EID: 0035476852     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.1196     Document Type: Article

References (41)

1. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
2. MYC and the cell cycle
3. Expression of the jimpy gene in the spinal cords of heterozygous female mice. 2. Oligodendroglial and endothelial cell hyperplasia
4. Disruption of the compacted myelin sheath of axons of the central nervous system in proteolipid protein-deficient mice
5. Adhesive properties of proteolipid protein are responsible for the compaction of CNS myelin sheath
6. PDGF-A signalling is a critical event in lung alveolar myofibroblast and alveogenesis
7. Oligodendrocyte dynamics and the role of PDGF in vivo
8. Cellular and molecular aspects of myelin protein gene expression
9. Loss of p27 Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation
10. Selective cell ablation in transgenic mice expressing E. coli nitroreductase
11. Proliferation and differentiation potential of rat forebrain oligodendroglial progenitors both in vitro and in vivo
12. Transgenic systems in studying myelin gene expression
13. Failure of central nervous system myelination in MBP/c-myc transgenic mice: Evidence for c-myc toxicity
14. Oligodendrocyte programmed cell death and central myelination deficiency induced in transgenic mice by synergism between c-myc and Oct-6
15. Conversion of normal behaviour to shiverer by myelin basic protein antisense cDNA in transgenic mice
16. Restoration of myelin formation by a single type of myelin basic protein in transgenic shiverer mice
17. Assembly of CNS myelin in the absence of proteolipid protein
18. The NG2 chondroitin sulphate proteoglycan: A multifunctional proteoglycan associated with immature cells
19. Development and differentiation of glial precursor cells in the rat cerebellum
20. Myelination in the absence of myelinassociated glycoprotein
21. Identification of an embryonic isoform of myelin basic protein that is expressed widely in the mouse embryo
22. Multiple essential functions of neuregulin in development
23. Mice deficient for the myelin associated glycoprotein show subtle abnormalities in myelin
24. Novel forms of mature myelin basic protein predominantly expressed in embryonic stage
25. Myc oncogenes and human neoplastic disease
26. Overexpression of multiple oncogenes related to histological grade of astrocytic glioma
27. Insertional mutagenesis inducing hypomyelination in transgenic mice
28. Delayed and incomplete myelination in a transgenic mouse mutant with abnormal oligodendrocytes
29. Mechanisms of apoptosis by c-myc
30. Development of oligodendrocytes and Schwann cells studied with a monoclonal antibody against galactocerebroside
31. Oligodendroglial progenitors labeled with the 04 antibody persist in the adult rat cerebral cortex in vivo
32. Immunohistochemical localisation of myelin basic protein and 2′3′-cyclic nucleotide 3′-phosphohydrolase in flattened membrane expansions produced by cultured oligodendrocytes
33. Phenotypic expression of X-linked genetic defects affecting myelination
34. Electron microscopic autoradiographic studies of gliognensis in rat optic nerve. 1. Cell proliferation
35. Regulation of myelin oligodendrocyte glycoprotein in different species throughout development
36. Intracellular redistribution of neuropeptides and secretory proteins during differentiation of neuronal cell lines
37. Differentiation and death of premyelinating oligodendrocytes in the developing rodent brain
38. Dysmyelination in transgenic mice resulting from expression of class 1 histocompatibility molecules in oligodendrocytes
39. Detection of initial stages of DNA fragmentation in apoptosis
40. Mouse models of myelin diseases
41. Unwrapping new layers of complexity in axon/glial relationships