SKY1 is involved in cisplatin-induced cell kill in Saccharomyces cerevisiae, and inactivation of its human homologue, SRPK1, induces cisplatin resistance in a human ovarian carcinoma cell line

Cancer Research

Volumn 61, Issue 19, 2001, Pages 6982-6986

  Schenk, Paul W ^a   Boersma, Antonius W M ^a   Burger, Herman ^a   Stoter, Gerrit ^a   Nooter, Kees ^a   Brandsma, Jourica A ^b   Den Dulk, Hans ^b   Brouwer, Jaap ^b  

^a JOSEPHINE NEFKENS INSTITUTE   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; CISPLATIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG ACTIVITY; GENE DISRUPTION; GENE INACTIVATION; GENE INSERTION; HUMAN; HUMAN CELL; NONHUMAN; OVARY CARCINOMA; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; TRANSPOSON;

ANTINEOPLASTIC AGENTS; CISPLATIN; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, FUNGAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; OLIGONUCLEOTIDES, ANTISENSE; OVARIAN NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TUMOR CELLS, CULTURED;

EID: 0035476801     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

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12. SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors
13. A comparison of clonogenic, microtetrazolium and sulforhodamine B assays for determination of cisplatin cytotoxicity in human ovarian carcinoma cell lines
14. Conservation in budding yeast of a kinase specific for SR splicing factors
15. A serine kinase regulates intracellular localization of splicing factors in the cell cycle
16. Phosphorylation regulates in vivo interaction and molecular targeting of serine/arginine-rich pre-mRNA splicing factors
17. SRPK2: A differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells
18. Conserved SR protein kinase functions in nuclear import and its action is counteracted by arginine methylation in Saccharomyces cerevisiae
19. Phosphorylation by Sky1p promotes Np13p shuttling and mRNA dissociation
20. Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing
21. The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs)
22. Rapid emergence of acquired cis- diamminedichloroplatinum(II) resistance in an in vivo model of human ovarian carcinoma
23. SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine I