Structural basis for the high-affinity interaction of nidogen-1 with immunoglobulin-like domain 3 of perlecan

EMBO Journal

Volumn 20, Issue 19, 2001, Pages 5342-5346

  Kvansakul, Marc ^a   Hopf, Michael ^b   Ries, Albert ^b   Timpl, Rupert ^b   Hohenester, Erhard ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

Immunoglobulin like domain; Interaction; Nidogen 1; Perlecan; X ray crystallography

Indexed keywords

ENTACTIN; IMMUNOGLOBULIN; PERLECAN;

AMINO ACID SEQUENCE; ARTICLE; BASEMENT MEMBRANE; BINDING SITE; CRYSTAL STRUCTURE; METAZOON; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; BASEMENT MEMBRANE; BINDING SITES; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; EXTRACELLULAR MATRIX PROTEINS; HEPARAN SULFATE PROTEOGLYCANS; IMMUNOGLOBULINS; MEMBRANE GLYCOPROTEINS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SURFACE PROPERTIES;

EID: 0035476687     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.19.5342     Document Type: Article

References (37)

1. Perlecan is essential for cartilage and cephalic development
2. Basement membrane heparan sulfate proteoglycan binds to laminin by its heparan sulfate chains and to nidogen by sites in the protein core
3. Crystallography & NMR system: A new software suite for macromolecular structure determination
4. Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface
5. The molecular structure of cell adhesion molecules
6. The CCP4 suite: Programs for protein crystallography
7. Perlecan maintains the integrity of cartilage and some basement membranes
8. Role of mesenchymal nidogen for epithelial morphogenesis in vitro
9. Still more complexity in mammalian basement membranes
10. An extensively modified version of MolScript which includes greatly enhanced coloring facilities
11. Recombinant nidogen consists of three globular domains and mediates binding of laminin to collagen IV
12. Many of the immunoglobulin superfamily domains in cell adhesion molecules and surface receptors belong to a new structural set which is close to that containing variable domains
13. X-ray structure determination of telokin, the C-terminal domain of myosin light chain kinase, at 2.8 Å resolution
14. Recombinant domain IV of perlecan binds to nidogens, laminin-nidogen complex, fibronectin, fibulin-2 and heparin
15. Crystal structure and mutational analysis of a perlecan-binding fragment of nidogen-1
16. Mapping of binding sites for nidogens, fibulin-2, fibronectin and heparin to different IG modules of perlecan
17. The evolution of cell adhesion
18. Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 Å resolution
19. Improved methods for building protein models in electron density maps and the location of errors in these models
20. Positioning of longitudinal nerves in C. elegans by nidogen
21. Nidogen-2: A new basement membrane protein with diverse binding properties
22. 2.0 Å crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region
23. Mapping out the basement membrane
24. Amino acid sequence of mouse nidogen, a multidomain basement membrane protein with binding activity for laminin, collagen IV and cells
25. Structural and genetic analysis of the laminin-nidogen interaction
26. Raster3D: Photorealistic molecular graphics
27. The absence of nidogen 1 does not affect murine basement membrane formation
28. AMoRe: An automated package for molecular replacement
29. The complete sequence of perlecan, a basement membrane heparan sulfate proteoglycan, reveals extensive similarity with laminin A chain, low density lipoprotein-receptor, and the neural cell adhesion molecule
30. 2F2 fragment from human fibronectin enhances gelatin binding
31. Mapping of nidogen binding sites for collagen type IV, heparan sulfate proteoglycan, and zinc
32. SMART: A web-based tool for the study of genetically mobile domains
33. Crystal structure of a heparin- and integrin-binding fragment of fibronectin
34. Supramolecular assembly of basement membranes
35. Hemicentin, a conserved extracellular member of the immunoglobulin superfamily, organizes epithelial and other cell attachments into oriented line-shaped junctions
36. Ligand-binding sites in Ig-like domains of receptor tyrosine kinases