Association of a Novel Point Mutation (C159G) of the CTLA4 Gene with Type 1 Diabetes in West Africans but not in Chinese

Diabetes

Volumn 50, Issue 9, 2001, Pages 2169-2171

  Osei Hyiaman, Douglas ^a,b,g   Hou, Lifang ^a,h   Zhiyin, Ren ^c   Zhiming, Zhang ^d   Yu, Haiquin ^e   Amankwah, Abena Agyeiwaa ^f   Harada, Shoji ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b Division of Endocrinology   (Ghana)

^c Taiyuan Center Hospital   (China)

^d SHANXI MEDICAL UNIVERSITY   (China)

^e Department of Internal Medicine   (China)

^f KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Ghana)

^g NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^h SIDNEY KIMMEL CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; ANTIBODY CONJUGATE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T-LYMPHOCYTE ANTIGEN 4; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN;

ADOLESCENT; ARTICLE; ASIAN; CHILD; ETHNOLOGY; FEMALE; GENETICS; GHANA; HUMAN; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NEGRO; POINT MUTATION; PRESCHOOL CHILD; SINGLE STRAND CONFORMATION POLYMORPHISM;

ADOLESCENT; AFRICAN CONTINENTAL ANCESTRY GROUP; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; ASIAN CONTINENTAL ANCESTRY GROUP; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FEMALE; GHANA; HUMANS; IMMUNOCONJUGATES; INFANT; MALE; POINT MUTATION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL;

EID: 0035463853     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.9.2169     Document Type: Article

References (17)

1. Lee Y-J, Huang F-Y, Lo F-S, Wang WC, Hsu CH, Kao HA, Yang TY, Chang JG: Association of CTLA4 gene A-G polymorphism with type 1 diabetes in Chinese Children. Clin Endocrin 52:153-157, 2000
2. MP Marron, LJ Raffel, HJ Garchon, CO Jacob, M Serrano-Rios, MT Martinez Larrad, WP Teng, Y Park, ZX Zhang, DR Goldstein, YW Tao, G Beaurain, JF Bach, HS Huang, DF Luo, A Zeidler, JI Rotter, MC Yang, T Modilevsky, NK Maclaren, JX She: Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups. Hum Mol Genet 6:1275-1282, 1997
3. Abe T, Takino H, Yamazaki H, Ozaki M, Sera Y, Kondo H, Sakamaki H, Kawasaki E, Awata T, Yamaguchi Y, Eguchi K: CTLA4 gene polymorphism correlates with the mode of onset of ICA512 Ab in Japanese type 1 diabetes. Diabetes Res Clin Pract 46:169-175, 1999
4. Hashimoto L, Habita C, Beressi JP, Delepine M, Besse C, Cambon-Thomsen A, Deschamps I, Rotter JI, Djoulah S, James MR, Froguel P, Weissenbach J, Luthrop GM, Juiler C: Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q. Nature 371:161-164, 1994
5. Todd JA: Genetic analysis of type 1 diabetes using whole genome approaches. Proc Natl Acad Sci USA 92:8560-8565, 1995
6. Todd JA, Farrall M: Panning for gold; genome-wide scanning for linkage in type 1 diabetes. Hum Mol Genet 5:1443-1448, 1996
7. Copeman JB, Cucca F, Hearne CM, Cornall RJ, Reed PW, Ronningen KS, Undlien DE, Nistico L, Buzzetti R, Tosi R, Pociot F, Nerup J, Cornelis F, Barnett AH, Bain SC, Todd JA; Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31-q33. Nat Genet 9:80-85, 1995
8. Nistico L, Buzzetti R, Pritchard LE, Van der Auwera B, Giovannini C, Bosi E, Martinez-Larrad MT, Serrano-Rios M, Chow CC, Cockram CS, Jacobs K, Mijovic C, Bain CS, Barnett AH, Vendewalle CL, Schuit F, Gorus FK, Belgian Diabetes Registry, Tosi R, Pozzilli P, Todd JA: The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Hum Mol Genet 5:1075-1080, 1996
9. Polymeropoulos MH, Rath DS, Xiao H, Merril CR: Dinucleotide repeat polymorphism at the human gene for insulin-like growth factor 1 (IGFI). Nucleic Acids Res 19:5797, 1991
10. Buzzetti R, Nistico L, Pozzili P, et al: The CTLA4 microsatellite identifies a new region on chromosome 2 linked to IDDM. Diabetologia 38 (Suppl. 1):A29, 1995
11. Harper K, Balzano C, Rouvier E, Mattei MG, Luciani MF, Golstein P: CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location. J Immunol 147:1037-1044, 1991
12. Donner H, Rau H, Walfish PG, Braun J, Siegmund T, Finke R, Herwig J, Usadel KH, Badenhoop K: CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus. J Clin Endocrin Metab 82:143-146, 1997
13. National Diabetes Data Group: Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28:1039-1057, 1979
14. Petersen JS, Hejnaes KR, Moody A, Karlsen AE, Marshall MO, Hoier-Madsen M, Boel E, Michelsen BK, Dyrberg T: Detection of GAD65 antibodies in diabetes and other autoimmune diseases using a simple radioligand assay. Diabetes 43:459-467, 1994
15. Naserke HE, Dozio N, Ziegler A-G, Bonifacio E: Comparison of a novel microassay for insulin autoantibodies with the conventional radiobinding assay. Diabetologia 41:681-683, 1998
16. Kanai N, Fujii T, Saito K, Yokoyama T: Rapid and simple method for preparation of genomic DNA from easily obtainable clotted blood. J Clin Pathol 47:1043-1044, 1994
17. Harada S, Okubo T, Tsutsumi M, Takase S, Muramatsu T: Investigation of genetic risk factors associated with alcoholism. Alcohol Clin Exp Res 20:293-296, 1996