Effects of intravenous lidocaine overdose on cardiac electrical activity and blood pressure in the horse

Equine Veterinary Journal

Volumn 33, Issue 5, 2001, Pages 434-437

  Meyer, G A ^a,b   Lin, H C ^a   Hanson, R R ^a   Hayes, T L ^a,c  

^a AUBURN UNIVERSITY   (United States)

^b Cliffe Veterinary Group   (United Kingdom)

^c Illinois Equine Hospital   (United States)

Author keywords

Colic; Horse; Ileus; Lidocaine; Toxicity

Indexed keywords

LIDOCAINE; LOCAL ANESTHETIC AGENT;

ANIMAL; ANIMAL BEHAVIOR; ANIMAL DISEASE; ARTICLE; BLOOD; BLOOD PRESSURE; BREATHING; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; HORSE; HORSE DISEASE; INTOXICATION; INTRAVENOUS DRUG ADMINISTRATION; LUNG FUNCTION TEST; MALE; PATHOPHYSIOLOGY; REFERENCE VALUE;

ANESTHETICS, LOCAL; ANIMALS; BEHAVIOR, ANIMAL; BLOOD PRESSURE; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; HORSE DISEASES; HORSES; INJECTIONS, INTRAVENOUS; LIDOCAINE; MALE; OVERDOSE; REFERENCE VALUES; RESPIRATION; RESPIRATORY FUNCTION TESTS;

EID: 0035459756     PISSN: 04251644     EISSN: None     Source Type: Journal    
DOI: 10.2746/042516401776254871     Document Type: Article

References (31)

1. Aggarwal, P. and Wali, J.P. (1993) Lidocaine in refractory status epilepticus: a forgotten drug in the emergency department. Am. J. Emerg. Med. 3, 243-244.
2. Cogar, W.B. (1997) Intravenous lidocaine as adjunctive therapy in the treatment of decompression illness. Ann. Emerg. Med. 29, 284-286.
3. Den Hartigh, J., Hilders, C.G., Schoemaker, R.C., Hulshof, J.H. and Vermeij, P. (1993) Tinnitus suppression by intravenous lidocaine in relation to its plasma concentration. Clin. Pharm. Therap. 54, 415-420.
4. Engelking, L.R., Blyden, G.T., Lofsted, J. and Greenblatt, D.J. (1987) Pharmacokinetics of antipyrine, acetaminophen, and lidocaine in fed and fasted horses. J. vet. Pharmacol. Therap. 10, 73-82.
5. Fishman, S.M.C. (1997) Intravenous lidocaine for treatment-resistant pruritus. Am. J. Med. 102, 584-585.
6. Groudine, S.B., Fisher, H.A.G., Kaufman, R.P.J., Patel, M.K., Wilkins, L.J., Mehta, S.A. and Lumb, P.D. (1998) Intravenous lidocaine speeds the return of bowel function, decreases postoperative pain, and shortens hospital stay in patients undergoing radical retropubic prostatectomy. J. Urol. 160, 1599-1601.
7. Haasio, J., Hekali, R. and Rosenberg, P.H. (1988) Influence of premedication on lignocaine-induccd acute toxicity and plasma concentrations of lignocaine. Br. J. Anaesth. 61, 131-134.
8. Haginomori, S., Makimoto, K., Araki, M., Kawakami, M. and Takahashi, H. (1995) Effect of lidocaine injection on EOAE in patients with tinnitus Acta Otolaryngol. 115, 488-492.
9. Hazra, J. (1971) The effects of intravenous lidocaine on optic evoked potentials in light and darkness. Anesth. 35, 384-393.
10. Hondeghem, L.M. and Mason, J.W. (1992) Agents used in cardiac arrhythmias. In: Basic & Clinical Pharmacology, 5th edn., Ed: B.G. Katzung, Appleton & Lange, Norwalk. pp 190-210.
11. Klein, S.W., Sutherland, R.I. and Morch, J.E. (1968) Hemodynamic effects of intravenous lidocaine in man. J. Can. med. Ass. 99, 472-475.
12. Lemmen, E.J., Klassen, M. and Duiser, B. (1978) Intravenous lidocaine in the treatment of convulsions. J. Am. med. Ass. 239, 2025.
13. Liu, P., Feldman, H. and Covino, B.G. (1980) Acute cardiovascular toxicity of lidocaine, bupivicaine and etidocaine in anesthetized, ventilated dogs. Anesth. 53, S231-S231.
14. Malone, E. D. (1998) Intravenous lidocaine for the treatment of equine ileus. In: Proceedings of the 6th Equine Colic Research Symposium, University of Georgia-Athens, Georgia. p 42.
15. Meyer, G.A. and Hanson, R.R. (2000) Nonstrangulating obstruction of the small intestine in the horse. Equine vet. Educ. 12, 150-159.
16. Nattel, S., Rinkenberger, R.L., Lehrman, L.L. and Zipes, D.P. (1979) Therapeutic blood lidocaine concentrations after local anesthesia for cardiac electrophysiolugic studies. N. Engl. J. Med. 301, 418-420.
17. Nution, R.L., Peng, G.W. and Chiou, W.L. (1979) High performance liquid chromatographic methods for simultaneous determination of lidocaine and its N-dealkylated metabolites in plasma. J. Chromatogr. 162, 466-473.
18. Patterson, M. (1996) Diagnostic aids in equine cardiology. In: Equine Cardiology, Blackwell Science, Oxford, pp 70-115.
19. Petersen, P. and Kastrup, J. (1987) Dercum's disease (adivosis dolorosa). Treatment of the severe pain with intravenous lidocaine. Pain 28, 77-80.
20. Petersen, P., Kastrup, J., Zeeberg, I. and Boysen, G. (1986) Chronic pain treatment with intravenous lidocaine. Neuro. Res. 8, 189-190.
21. Rey, E., Radvanyi-Bouvet, M.F., Bodiou, C., Richard, M.O. and Olive, G. (1990) Intravenous lidocaine in the treatment of convulsions in the neonatal period: monitoring plasma levels. Therap. Drug Mon. 12, 316-320.
22. Rimback, G., Cassuto, J. and Tollesson, P.O. (1990) Treatment of postoperative paralytic ileus by intravenous lidocaine infusion. Anesth. Analg. 70, 414-419.
23. Scott, D.B. (1986) Toxic effects of local anesthetic agents on the central nervous system. Br. J. Anaesth. 58, 732-735.
24. Shiomi, Y., Funabiki, K., Naito, Y., Fujiki, N. and Tsuji, J. (1997a) The effect of intravenous lidocaine injection on hearing thresholds. Auris Nasus Larynx 24, 351-356.
25. Shiomi, Y., Nagamine, T., Fujiki, N., Hirano, S., Naito, Y., Shibasaki, H. and Honjo, I. (1997b) Tinnitus remission by lidocaine demonstrated by auditory-evoked magnetoencephalogram: a preliminary report. Acta Otolaryngol. 117, 31-34.
26. Skarda, R.T. (1991) Local anesthetics and local anesthetic techniques in horses. In: Equine Anesthesia - Monitoring and Emergency Therapy. Eds: W.M. Muir and J.A.E. Hubbell, Mosby Year Book, St. Louis. pp 199-246.
27. Stenson, R.E., Constantino, R.T. and Harrison, D.C. (1971) Interrelations of hepatic blood flow, cardiac output, and blood levels of lidocaine in man. Circulation 63, 205-211.
28. Tanelian, D.L. and Maclver, M.B. (1991) Analgesic concentrations of lidocaine suppress tonic A-delta and C fiber discharges produced by acute injury. Anesth. 74, 934-936.
29. Ueda, S., Aso, S., Watanabe, Y. and Mizukoshi, K. (1993) Changes in auditory evoked responses during intravenous lidocaine. Acta Otolaryngol. 504, 89-93.
30. Wallace, M.S.L. (1997) Concentration-effect relations for intravenous lidocaine infusions in human volunteers: Effects on acute sensory thresholds and capsaicin-evoked hyperpathia. Anesth. 86, 1262-1272.
31. Wilcke, J.R., Davis, L.E. and Neff-Davis, C.A. (1983) Determination of lidocaine concentrations producing therapeutic and toxic effects in dogs. J. vet. Pharm. Therap. 2, 105-112.