Sudden termination of G-CSF injection leads to apoptosis of a large proportion of increased granulocytes

Oncology Reports

Volumn 8, Issue 5, 2001, Pages 1027-1029

  Ogawa, Yasuhiro ^a  

^a KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

Apoptosis; G CSF; Granulocyte; Mitochondria; Mitochondrial membrane potential

Indexed keywords

ANTINEOPLASTIC AGENT; DOCETAXEL; DRUG DERIVATIVE; PACLITAXEL; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; TAXOID;

AGRANULOCYTOSIS; APOPTOSIS; ARTICLE; BLOOD CELL COUNT; BLOOD DONOR; BREAST TUMOR; CELL MEMBRANE POTENTIAL; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; DRUG EFFECT; FEMALE; GRANULOCYTE; HUMAN; MITOCHONDRION; PATHOLOGY; SUBCUTANEOUS DRUG ADMINISTRATION;

AGRANULOCYTOSIS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BLOOD CELL COUNT; BLOOD DONORS; BREAST NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GRANULOCYTE COLONY STIMULATING FACTOR, RECOMBINANT; GRANULOCYTES; HUMANS; INJECTIONS, SUBCUTANEOUS; MEMBRANE POTENTIALS; MITOCHONDRIA; PACLITAXEL; TAXOIDS;

EID: 0035458775     PISSN: 1021335X     EISSN: None     Source Type: Journal    
DOI: 10.3892/or.8.5.1027     Document Type: Article

References (2)

1. Kobayashi T and Robinson JM: A novel intracellular compartment with unusual secretory properties in human neutrophils. J Cell Biol 113: 743-756, 1991.
2. Hotchkiss RS, Swanson PE, Knudson CM, Chang KC, Cobb JP, Osborne DF, Zollner KM, Buchman TG, Korsmeyer SJ and Karl IE: Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis. J Immunol 162: 4148-4156, 1999.