Synthesis of 11-aryl-5H-imidazo[2,1-c][1,4]benzodiazepines and their benzodiazepine and A1 adenosine binding activity

Farmaco

Volumn 56, Issue 10, 2001, Pages 771-778

  Castellano, Sabrina ^a   Zorzin, Laura ^a   Florio, Chiara ^a   Frausin, Fabiana ^a   Stefancich, Giorgio ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Adenosine receptors; Benzodiazepine receptors; Imidazobenzodiazepines; Radioligand binding

Indexed keywords

10,11 DIHYDRO 11 (4 AMINOPHENYL) 5H IMIDAZO[2,1 C][1,4]BENZODIAZEPINE; 10,11 DIHYDRO 5H IMIDAZO[2,1 C][1,4]BENZODIAZEPINE DERIVATIVE; 11 (4 AMINOPHENYL) 5H IMIDAZO[2,1 C][1,4]BENZODIAZEPINE; 5H IMIDAZO[2,1 C][1,4]BENZODIAZEPINE DERIVATIVE; [1 (2 NITROBENZYL) 1H IMIDAZOL 2 YL]METHANONE DERIVATIVE; [4 (1H IMIDAZOL 1 YL)PHENYL] [1 (2 NITROBENZYL) 1H IMIDAZOL 2 YL]METHANONE; [4 (4 METHYLPIPERAZIN 1 YL)PHENYL][1 (2 NITROBENZYL) 1H IMIDAZOL 2 YL]METHANONE; ADENOSINE A1 RECEPTOR; BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHEMICAL REACTION; CONTROLLED STUDY; CYCLIZATION; DRUG ACTIVITY; DRUG BINDING; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; LIGAND BINDING; NONHUMAN; RADIOASSAY; RAT; REACTION ANALYSIS; RECEPTOR AFFINITY; REDUCTION;

ANIMALS; ANTI-ANXIETY AGENTS; BENZODIAZEPINES; BINDING SITES; MALE; MICE; MICE, INBRED CBA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P1;

EID: 0035445883     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(01)01133-8     Document Type: Article

References (16)

1. Ligand interaction at the benzodiazepine receptor
2. Research on nitrogen heterocyclic compounds: XIII. Synthesis of 5H-imidazo[2,1-c][1,4]benzodiazepine, a novel tricyclic ring system
3. New psychotropic agents. I. Synthesis and pharmacologic activity of derivatives of 5H-imidazo-[2,1-c][1,4]benzodiazepine
4. Benzodiazepine interaction with adenosine systems explains some anomalies in GABA hypothesis
5. The reduction of nitroarenes with iron/acetic acid
6. Titanium (III) chloride for the reduction of heteroaromatic and aromatic nitro compounds
7. Structure-activity relationships of 1,2,4-triazolo[1,5-a] quinoxalines and their 1-deaza analogues imidazo[1,2-a]quinoxalines at the benzodiazepine receptor
8. Agonist and antagonist benzodiazepine receptor interaction in vitro
9. Nucleoside transport inhibitors: Structure activity relationships and potential therapeutic applications
10. Actions of benzodiazepines and the benzodiazepine antagonist flumazenil may involve adenosine
11. Involvement of the adenosine neuromodulatory system in the benzodiazepine-induced depression of excitatory synaptic transmissions in rat hippocampal neurons in vitro
12. Characterization of [3H]-imidazenil binding to rat brain membranes
13. Strain-related differences in adenosine receptor density and in behavioral sensitivity to adenosine
14. Protein measurement with the Folin phenol reagent
15. Neurotransmitter, hormone, or drug receptor binding models