Spin-labeled 1-alkyl-1-nitrosourea synergists of antitumor antibiotics

Anti-Cancer Drug Design

Volumn 16, Issue 4-5, 2001, Pages 247-253

  Gadjeva, Vesselina ^a   Koldamova, Radosveta ^b  

^a TRAKIA UNIVERSITY   (Bulgaria)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Cytotoxicity; EPR; Nitrosourea; Spin labeled; Synergistic effect

Indexed keywords

1 ETHYL 3 [4 (2,2,6,6 TETRAMETHYLPIPERIDINE 1 OXYL)] 1 NITROSOUREA; ANTINEOPLASTIC ANTIBIOTIC; BLEOMYCIN; EPIRUBICIN; LOMUSTINE; NITROSOUREA DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CYTOTOXICITY; DRUG DISTRIBUTION; DRUG POTENTIATION; DRUG SYNTHESIS; ELECTRON SPIN RESONANCE; HUMAN; HUMAN CELL; LUNG; LYMPHATIC LEUKEMIA; MOUSE; NITROSATION; NONHUMAN; PRIORITY JOURNAL; SPIN LABELING; TUMOR CELL;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, ALKYLATING; BLEOMYCIN; CELL SURVIVAL; CHEMISTRY, PHYSICAL; DRUG SYNERGISM; EPIRUBICIN; FREE RADICAL SCAVENGERS; HALF-LIFE; HEMATOLOGIC NEOPLASMS; HUMANS; LEUKEMIA; LOMUSTINE; LYMPHOCYTES; MICE; MICE, INBRED C57BL; NITROSOUREA COMPOUNDS; SPIN LABELS; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0035437398     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Arrieta O., Guevara P., Reyes S., Ortiz A., Rembao D., Sotelo J. (1998) Protamine inhibits angiogenesis and growth of C6 rat glioma; a synergistic effect when combined with carmustine. European Journal of Cancer, 34, 2101.
2. Babson J.R., Reed D.J. (1978) Inactivation of glutathione reductase by 2-chloroethyl nitrosourea-derived isocyanates. Biochemical and Biophysical Research Communications, 83, 754.
3. Bird M.C., Bosanquet A.G., Forskitt S., Gilby E.D. (1988) Long-term comparison of results of a drug sensitivity assay in vitro with patient response in lymphatic neoplasms. Cancer, 61, 1104.
4. Carter S.K. (1985) Bleomycin chemotherapy. In Bleomycin Chemotherapy, Sikic B.I., Rozencweig M., Carter S.K. (eds), p. 3. Academic Press: New York.
5. Carter S.K., Schabel F.M. Jr, Broder L.E., Johnston T.P. (1972) 1,3-Bis(2-chloroethyl)-1-nitrosourea (bcnu) and other nitrosoureas in cancer treatment: A review. Advances in Cancer Research, 16, 273.
6. Doroshow J.H. (1983) Anthracycline antibiotic-stimulated superoxide, hydrogen peroxide, and hydroxyl radical production by NADH dehydrogenase. Cancer Research, 43, 4543.
7. Emmerson P.T., Howard-Flanders P. (1965) Preferential sensitization of anoxic bacteria to x-rays by organic nitroxide-free radicals. Radiation Research, 26, 54.
8. Erickson L.C., Bradley M.O., Kohn K.W. (1978) Measurements of DNA damage in Chinese hamster cells treated with equitoxic and equimutagenic doses of nitrosoureas. Cancer Research, 38, 3379.
9. Gadjeva V., Raikova E., Raikov Z., Ivanova T., Stefanova M. (1989) Investigation of some physicochemical properties of new nitrosourea derivatives - Potential antitumour agents. Comptes Rendus de l'Academie Bulgarienne des Sciences, 42, 131.
10. Gadjeva V., Zheleva A., Raikova E. (1999) Modulating effect of new potential antimelanomic agents, spin-labeled triazenes and nitrosoureas on DOPA-oxidase activity of tyrosinase. Cancer Biochemistry Biophysics, 17, 99.
11. Gadzheva V., Ichimori K., Nakazawa H., Raikov Z. (1994) Superoxide scavenging activity of spin-labeled nitrosourea and triazene derivatives. Free Radical Research, 21, 177.
12. Gadzheva V., Ichimori K., Raikov Z., Nakazawa H. (1997) New method to measure the carbamoylating activity of nitrosoureas by electron paramagnetic resonance spectroscopy. Free Radical Research, 27, 197.
13. Giaccia A.J., Lewis A.D., Denko N.C., Cholon A., Evans J.W., Walden C.A., Stamato T.D., Brown J.M. (1991) The hypersensitivity of the Chinese hamster ovary variant BL-10 to bleomycin killing is due to a lack of glutathione S-transferase-alphaactivity. Cancer Research, 51, 4463.
14. Gnewuch C.T., Sosnovsky G. (1997) A critical appraisal of the evolution of N-nitrosoureas as anticancer drugs. Chemical Reviews, 97, 829.
15. Isobe H., Wada Y., Ryo J., Matsushita T., Makino T., Satoh B., Kanaya S., Katayama T., Ohtoshi M. (1985) An effective chemotherapy regimen for liver metastasis from retroperitoneal fibrosarcoma: Report of a case. Surgery Today, 27, 463.
16. Kann H. (1981) Carbamoylating activity of nitrosoureas. In Nitrosoureas, Current Status and New Developments. Prestayko A.W., Croove S.T., Baker I.H., Carter S.K., Shein P.S. (eds), p. 95. Academic Press: New York.
17. Kann H.E. Jr, Blumenstein B.A., Petkas A., Schott M.A. (1980) Radiation synergism by repair-inhibiting nitrosoureas in L1210 cells. Cancer Research, 40, 771.
18. Kolonina I.V., Bogomolova N.N., Zasukhina G.P. (1987) Repair of DNA damage induced by gamma radiation and UV and gamma mimetics in virus-infected human cells. Radiobiologiia, 27, 3.
19. Lea J.S., Garner H.J., Butler J., Hoey B.M., Ward T.H. (1988) The lack of correlation between toxicity and free radical formation of two diaziridinylbenzoquinones. Biochemical Pharmacology, 37, 2023.
20. Lee F.Y., Sieman D.W., Sutherland R.M. (1989) Changes in cellular glutathione content during adriamycin treatment in human ovarian cancer - A possible indicator of chemosensitivity. British Journal of Cancer, 60, 291.
21. Martinez J., Oiry J., Imbach J.L., Wintemitz F. (1982) Activated N-nitrosocarbamates for regioselective synthesis of N-nitrosoureas. Journal of Medicinal Chemistry, 25, 178.
22. Mitchell J.B., Biaglow J.E., Russo A. (1988) Role of glutathione and other endogenous thiols in radiation protection. Pharmacology & Therapeutics, 39, 269.
23. Perry J.R., Brown M.T., Gockerman J.P. (1998) Acute leukemia following treatment of malignant glioma. Journal of Neurooncology, 40, 39.
24. Pyrhonen S., Hahka-Kemppinen M., Muhonen T. (1992) A promising interferon plus four-drug chemotherapy regimen for metastatic melanoma. Journal of Clinical Oncology, 10, 1919.
25. Rachkova M., Raikova E., Raikov Z. (1991) New nitrosoureas and their spin-labeled derivatives influence DOPA oxidase activity of tyrosinase. Cancer Biochemistry Biophysics, 12, 59-64.
26. Raikov Z., Todorov D., Ilarionova M., Demirov G., Tsanova T., Kafalieva D. (1985) Synthesis and study of spin-labeled nitrosoureas. Cancer Biochemistry Biophysics, 7, 343.
27. Ross W. (1985) DNA topoisomerases as targets for cancer therapy. Biochemical Pharmacology, 34, 4191.
28. Sikic B.I. (1985) In Bleomycin Chemotherapy. Sikic B.I., Rozencweig M., Carter S.K. (eds), p. 247. Academic Press: New York.
29. Simeonova M., Ivanova T., Raikov Z., Konstantinov H. (1994) Tissue distribution of polybutylcyanoacrylate nanoparticles loaded with spin-labelled nitrosourea in Lewis lung carcinoma-bearing mice. Acta Physiologica et Pharmacologica Bulgarica, 20, 77.
30. Sosnovsky G., Li S.W., Rao N.U.M. (1987) In the search for new anticancer drugs, XXI. Spin-labeled nitrosoureas. Zeitschrift für Naturforschung. C. Journal of Biosciences, 42, 921.
31. Stahl W., Denkel E., Eisenbrand G. (1988) Influence of glutathione on the mutagenicity of 2-chloroethylnitrosoureas. Mutagenic potential of glutathione derivatives formed from 2-chloroethylnitrosoureas and glutathione. Mutation Research, 206, 459.
32. Wheeler G.P., Bowdon J.B., Grimsley J.A., Lloyd H.H. (1974) Interrelationships of some chemical, physicochemical, and biological activities of several 1-(2-haloethyl)-1-nitrosoureas. Cancer Research, 34, 194.
33. Weisenthal L.M., Shoemaker R.H., Marsden J.A., Dill P.L., Baker J.A., Moran J.A. (1984) In vitro chemosensitivity assay based on the concept of total tumor cell kill. Recent Results in Cancer Research, 94, 161.
34. Zheleva À., Gadjeva V. (2001) Spin-labeled nitrosoureas and triazenes and their nonlabeled clinically used analogues - A comparative study on their physicochemical properties and antimelanomic effects. International Journal of Pharmaceutics, 212, 257.