α-smooth muscle actin and proliferating cell nuclear antigen expression in focal segmental glomerulosclerosis: Functional and structural parameters of renal disease progression

Brazilian Journal of Medical and Biological Research

Volumn 34, Issue 8, 2001, Pages 985-991

  Geleilete, T J M ^a   Costa, R S ^a   Dantas, M ^a   Coimbra, T M ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Focal segmental glomerulosclerosis; PCNA; Proliferating cell nuclear antigen; Proteinuria; Renal disease progression; Renal failure; Renal fibrosis; Smooth muscle actin

Indexed keywords

GLOMERULUS;

ACTIN; CYCLINE; MONOCLONAL ANTIBODY;

ARTICLE; BIOPSY; BIOSYNTHESIS; CASE CONTROL STUDY; CHEMISTRY; CHILD; DISEASE COURSE; FEMALE; FOCAL GLOMERULOSCLEROSIS; GLOMERULUS; HUMAN; IMMUNOHISTOCHEMISTRY; INFANT; KIDNEY CORTEX; MALE; METABOLISM; PATHOLOGY; PRESCHOOL CHILD; SMOOTH MUSCLE;

ACTINS; ANTIBODIES, MONOCLONAL; BIOPSY; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; DISEASE PROGRESSION; FEMALE; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; KIDNEY CORTEX; KIDNEY GLOMERULUS; MALE; MUSCLE, SMOOTH; PROLIFERATING CELL NUCLEAR ANTIGEN;

EID: 0035430928     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2001000800003     Document Type: Article

References (29)

1. Eddy AA (1996). Molecular insights into renal interstitial fibrosis. Journal of the American Society of Nephrology, 7: 2495-2508.
2. Howie AJ, Rowlands DC, Reynolds GM & Barnes AD (1995). Measurement of proliferation in renal biopsy specimens: Evidence of subclinical tubular damage in the nephrotic syndrome. Nephrology, Dialysis, Transplantation, 10: 2212-2218.
3. Zhang G, Moorhead PJ & El Nahas AM (1995). Myofibroblasts and progression of experimental glomerulonephritis. Experimental Nephrology, 3: 308-318.
4. Hewitson TD & Becker GJ (1995). Interstitial myofioroblasts in IgA glomerulonephritis. American Journal of Nephrology, 15: 111-117.
5. Muchaneta-Kubara EC & El Nahas AM (1997). Myofibroblast phenotypes expression in experimental renal scarring. Nephrology, Dialysis, Transplantation, 12: 904-915.
6. Boukhalfa G, Desmouliere A, Rondeau E, Gabbiani G & Sraer JD (1996). Relationship between alpha-smooth muscle actin expression and fibrotic changes in human kidney. Experimental Nephrology, 4: 241-247.
7. Groma V, Marcussen N & Olsen S (1997). A quantitative immunohistochemical study of the expression of mesangial alpha-smooth muscle actin and proliferation marker Ki-67 in glomerulonephritis in man. Virchows Archives, 431: 345-350.
8. Hattori M, Horita S, Yoshioka T, Yamaguchi Y, Kawaguchi H & Ito K (1997). Mesangial phenotypic changes associated with cellular lesions in primary focal segmental glomerulosclerosis. American Journal of Kidney Diseases, 30: 632-638.
9. Desmouliere A, Geinoz A, Gabbiani F & Gabbiani G (1993). Transforming growth factor-beta-1 induces alpha-smooth muscle actin expression in granulation-tissue myofibroblasts and in quiescent and growing cultured fibroblasts. Journal of Cell Biology, 122: 103-111.
10. Tang WW, Ulich TR, Lacey DL, Hill DC, Qi MY, Kaufman SA, Van GY, Tarpley JE & Yee JS (1996). Platelet-derived growth factor-BB induces renal tubulointerstitial myofibroblast formation and tubulointerstitial fibrosis. American Journal of Pathology, 148: 1169-1180.
11. Johnson RJ, Iida H, Alpers CE, Majesky MW, Schwartz SM, Pritzl P, Gordon K & Gown AM (1991). Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis. Alpha-smooth muscle actin is a marker of mesangial cell proliferation. Journal of Clinical investigation, 87: 847-858.
12. Kubben FJGM, Peeters-Haesevoets A, Engels LGJB, Baeten CGMI, Schutte B, Arends JW, Stockbrugger RW & Blijham GH (1994). Proliferating cell nuclear antigen (PCNA): a new marker to study colonic cell proliferation. Gut, 35: 530-535.
13. Weisgerber UM, Boeing H, Nemitz R, Raedsch R & Waldhen R (1993). Proliferation cell nuclear antigen (clone 19A2) correlates with 5-bromo-2-deoxyuridine labeling in human colonic epithelium. Gut. 34: 1587-1592.
14. Kliem V, Johnson RJ, Alpers CE, Yoshimura A, Couser WG, Koch KM & Floege J (1996). Mechanism involved in the pathogenesis of tubulointerstitial fibrosis in 5/6 nephrectomized rats. Kidney International, 49: 666-678.
15. Alpers CE, Hudkins KL, Gown AM & Johnson RJ (1992). Enhanced expression of "muscle-specific" actin in glomerulonephritis. Kidney International, 41: 1134-1142.
16. Haygen HN (1953). The determination of endogenous creatinine in plasma and urine. Journal of Clinical and Laboratory Investigation, 17: 381-387.
17. Border WA, Okuda S, Languino LR, Sporn MB & Ruoslahti E (1990). Suppression of experimental glomerulonephritis by antiserum against transforming growth factor-ß. Nature, 346: 371-374.
18. Dominguez GCS, Costa RS, Dantas VI, Kimachi T, Piuci CR & Coimbra TM (1998). Transforming growth factor-ß activity in urine of patients with glomerulonephritis is related to their renal functional and structural changes. Nephrology, 4: 31-36.
19. de Freitas ASM, Coimbra TM, Costa RS & Baroni EA (1998). Urinary transforming growth factor-ß excretion and renal production of TGF-ß in rats with subtotal renal ablation: Effect of enalapril and nifedipine. Nephron, 78: 302-309.
20. Coimbra T, Wiggins RC, Jung WN, Merritt S & Phan SH (1991). Transforming growth factor-ß production in anti-glomerular basement membrane disease in the rabbit. American Journal of Pathology, 138: 223-234.
21. Yamamoto T, Noble NA, Cohen AH, Nast CC, Hishida A, Gold LI & Border WA (1996). Expression of transforming growth factor-ß isoforms in human glomerular diseases. Kidney International, 49: 461-469.
22. Niemir ZI, Stein H, Nororha IL, Kruger C, Andrassy K, Ritz E & Waldherr R (1995). PDGF and TGF-ß contribute to the natural course of human-IgA glomerulonephritis. Kidney International, 48: 1530-1541.
23. Cortes P, Riser BL, Zhao XY & Narins RG (1994). Glomerular volume expansion and mesangial cell mechanical strain: Mediators of glomerular pressure injury. Kidney International, 45 (Suppl): S11-S16.
24. Johnson RJ, Alpers CE, Yoshimura A, Lombardi D, Pritzl P, Floege J & Schwartz SM (1992). Renal injury from angiotensin II-mediated hypertension. Hypertension, 19; 464-474
25. Kagami S, Border WA, Miller DE & Noble NA (1994). Angiotensm II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-ß expression in rat glomerular mesangial cells. Journal of Clinical Investigation, 93: 2431-2437.
26. Eddy AA, McCulloch L, Adams J & Liu E (1989). Interstitial nephritis induced by protein-overload proteinuria. American Journal of Pathology, 135: 719-733.
27. Zoja C, Doradelli R, Colleoni S, Figliuzzi M, Bonazzola S, Morigi M & Remuzzi G (1998). Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kB activation. Kidney International, 53: 1608-1615.
28. Zoja C, Morigi M, Figliuzzi M, Bruzzi I, Oldroyd S, Benigni A, Ronco PM & Remuzzi G (1995). Proxima tubular cell synthesis and secretion of endothelin-1 on challenge with albumin and other proteins. American Journal of Kidney Diseases, 26: 934-941.
29. Baroni EA, Costa RS, Volpini RA & Coimbra TM (1999). Sodium bicarbonate treatment reduces renal injury, renal production of TGF-ß, and urinary transforming growth factor-ß excretion in rats with doxorubicin-induced nephropathy. American Journal of Kidney Diseases, 34: 328-337.